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3.5.1.32: hippurate hydrolase

This is an abbreviated version!
For detailed information about hippurate hydrolase, go to the full flat file.

Word Map on EC 3.5.1.32

Reaction

hippurate
+
H2O
=
benzoate
 +
glycine

Synonyms

Benzoylglycine amidohydrolase, hippurate hydrolase, hippuricase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.32 hippurate hydrolase

Substrates Products

Substrates Products on EC 3.5.1.32 - hippurate hydrolase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-acetyl-N-benzoyl-L-alanine + H2O
4-acetylbenzoic acid + L-alanine
show the reaction diagram
-
low activity
-
?
4-acetyl-N-benzoylglycine + H2O
4-acetylbenzoic acid + glycine
show the reaction diagram
-
-
-
?
4-aminobenzoyl-glutamate + H2O
4-aminobenzoate + glutamate
show the reaction diagram
-
-
-
-
?
4-chloro-N-benzoyl-L-alanine + H2O
4-chlorobenzoic acid + L-alanine
show the reaction diagram
-
-
-
?
4-chloro-N-benzoylglycine + H2O
4-chlorobenzoic acid + glycine
show the reaction diagram
-
-
-
?
4-hydroxy-N-benzoyl-L-alanine
4-hydroxybenzoic acid + L-alanine
show the reaction diagram
-
low activity
-
?
4-hydroxy-N-benzoylglycine + H2O
4-hydroxybenzoic acid + glycine
show the reaction diagram
-
-
-
?
4-hydroxy-N-benzoylglycine-L-histidyl-L-leucine + H2O
4-hydroxybenzoic acid + L-histidyl-L-leucine
show the reaction diagram
-
-
-
?
4-nitro-N-benzoyl-L-alanine + H2O
4-nitrobenzoic acid + L-alanine
show the reaction diagram
-
-
-
?
4-nitro-N-benzoylglycine + H2O
4-nitrobenzoic acid + glycine
show the reaction diagram
-
best substrate
-
?
benzyloxycarbonyl-glycyl-L-phenylalanine + H2O
benzoic acid + ?
show the reaction diagram
-
-
-
?
glycyl-L-leucine + H2O
glycine + L-leucine
show the reaction diagram
-
-
-
?
glycylglycylglycine + H2O
glycine + glycylglycine
show the reaction diagram
-
-
-
?
hippurate + H2O
benzoate + glycine
show the reaction diagram
itoic acid + H2O
2,3-dihydroxybenzoic acid + glycine
show the reaction diagram
-
low specificity
-
?
N-(4-nitrobenzoyl)-Gly-Gly-Gly + H2O
4-nitrobenzoic acid + Gly-Gly-Gly
show the reaction diagram
-
-
-
?
N-acetyl-DL-alanine + H2O
acetic acid + DL-alanine
show the reaction diagram
-
-
-
?
N-acetyl-DL-asparagine + H2O
acetic acid + DL-asparagine
show the reaction diagram
-
low activity
-
?
N-acetyl-DL-methionine + H2O
acetic acid + DL-methionine
show the reaction diagram
-
low activity
-
?
N-acetyl-DL-phenylalanine + H2O
acetic acid + DL-phenylalanine
show the reaction diagram
-
low activity
-
?
N-acetyl-DL-tryptophan + H2O
acetic acid + DL-tryptophan
show the reaction diagram
-
-
-
?
N-acetyl-DL-valine + H2O
acetic acid + DL-valine
show the reaction diagram
-
very low activity
-
?
N-acetyl-glycine + H2O
acetic acid + glycine
show the reaction diagram
-
low activity
-
?
N-acetyl-L-cysteine + H2O
acetic acid + L-cysteine
show the reaction diagram
-
-
-
?
N-acetyl-L-glutamine + H2O
acetic acid + L-glutamine
show the reaction diagram
-
low activity
-
?
N-acetylalanine + H2O
acetate + alanine
show the reaction diagram
-
-
-
-
?
N-acetylglycine + H2O
acetate + glycine
show the reaction diagram
-
-
-
-
?
N-benzoyl-(S-benzoyl)-DL-cysteine + H2O
benzoic acid + S-benzoyl-DL-cysteine
show the reaction diagram
-
low activity
-
?
N-benzoyl-DL-alanine + H2O
benzoic acid + DL-alanine
show the reaction diagram
-
-
-
?
N-benzoyl-DL-alloisoleucine + H2O
benzoic acid + DL-alloisoleucine
show the reaction diagram
-
-
-
?
N-benzoyl-DL-arginine + H2O
benzoic acid + DL-arginine
show the reaction diagram
-
-
-
?
N-benzoyl-DL-asparagine + H2O
benzoic acid + DL-asparagine
show the reaction diagram
-
-
-
?
N-benzoyl-DL-glutamine + H2O
benzoic acid + DL-glutamine
show the reaction diagram
-
-
-
?
N-benzoyl-DL-histidine + H2O
benzoic acid + DL-histidine
show the reaction diagram
-
-
-
?
N-benzoyl-DL-leucine + H2O
benzoic acid + DL-leucine
show the reaction diagram
-
-
-
?
N-benzoyl-DL-methionine + H2O
benzoic acid + DL-methionine
show the reaction diagram
N-benzoyl-DL-phenylalanine + H2O
benzoic acid + DL-phenylalanine
show the reaction diagram
-
-
-
?
N-benzoyl-DL-serine + H2O
benzoic acid + DL-serine
show the reaction diagram
-
-
-
?
N-benzoyl-DL-threonine + H2O
benzoic acid + DL-threonine
show the reaction diagram
-
-
-
?
N-benzoyl-DL-tryptophan + H2O
benzoic acid + DL-tryptophan
show the reaction diagram
-
low activity
-
?
N-benzoyl-DL-tyrosine + H2O
benzoic acid + DL-tyrosine
show the reaction diagram
-
-
-
?
N-benzoyl-DL-valine + H2O
benzoic acid + DL-valine
show the reaction diagram
-
low activity
-
?
N-benzoyl-L-alanine + H2O
benzoic acid + L-alanine
show the reaction diagram
-
-
-
?
N-benzoyl-L-aminobutyric acid + H2O
benzoic acid + L-aminobutyric acid
show the reaction diagram
-
low activity
-
?
N-benzoyl-L-valine + H2O
benzoic acid + L-valine
show the reaction diagram
-
poor substrate
-
?
N-benzoylalanine + H2O
benzoate + alanine
show the reaction diagram
-
-
-
-
?
N-benzoylglutamate + H2O
benzoate + glutamate
show the reaction diagram
-
-
-
-
?
N-benzoylglycine + H2O
benzoic acid + glycine
show the reaction diagram
N-benzoylglycylglycylglycine + H2O
benzoic acid + glycylglycylglycine
show the reaction diagram
-
-
-
?
N-benzoylmethionine + H2O
benzoate + methionine
show the reaction diagram
-
-
-
-
?
N-benzoylphenylalanine + H2O
benzoate + phenylalanine
show the reaction diagram
-
-
-
-
?
N-benzoylvaline + H2O
benzoate + valine
show the reaction diagram
-
-
-
-
?
N-[(4-hydroxyphenyl)carbonyl]glycine + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
substrate specificity, the enzyme also shows metallocarboxypeptidase activity with carboxypeptidase substrates in vitro, displaying its highest activity against N-benzoyl-linked small aliphatic acids, overview, the enzyme does not hydrolyze typical substrates for aminopeptidases, lysine-p-nitroanilide, leucine-p-nitroanilide, or endopeptidases, N-benzoylarginine-p-nitroanilide, succinylphenylalanine-4-nitroanilide
-
-
?