3.5.1.29: 2-(acetamidomethylene)succinate hydrolase

This is an abbreviated version!
For detailed information about 2-(acetamidomethylene)succinate hydrolase, go to the full flat file.

Word Map on EC 3.5.1.29

Reaction

2-(Acetamidomethylene)succinate
+ 2 H2O =
acetate
+
succinate semialdehyde
+
NH3
+
CO2

Synonyms

alpha-(N-acetylaminomethylene)succinic acid hydrolase, compound A hydrolase, alpha-(N-acetylaminomethylene)succinic acid amidohydrolase, AAMSAH, AAMS amidohydrolase, (E)-2-(acetamidomethylene)succinate hydrolase, E-2AMS hydrolase, mlr6787

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.29 2-(acetamidomethylene)succinate hydrolase

General Information

General Information on EC 3.5.1.29 - 2-(acetamidomethylene)succinate hydrolase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
binding of (E)-2-(acetamidomethylene)succinate to the enzyme is crucial for biological function of the enzyme and the last step reaction of vitamin B6 biological degradation
metabolism
additional information
molecular docking of the two substrate isomers E- and Z-2-(acetamidomethylene)succinate to the hydrolase, molecular dynamics simulations and calculations of binding free energies, usage of X-ray crystal structure of E-2AMS hydrolase, PDB ID 3KXP, overview