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3.5.1.20: citrullinase

This is an abbreviated version!
For detailed information about citrullinase, go to the full flat file.

Word Map on EC 3.5.1.20

Reaction

L-citrulline
+
H2O
=
L-ornithine
+
CO2
+
NH3

Synonyms

citrulline hydrolase, citrulline ureidase, CTU, L-citrulline N5-carbamoyldehydrolase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.20 citrullinase

Engineering

Engineering on EC 3.5.1.20 - citrullinase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
generation of a nonpolar deletion DELTActu mutant. Deletion of the ctu gene results in loss of CTU activity, which is restored by transcomplementing the ctu gene. Loss of CTU does not affect acellular growth, but attenuates intramacrophage survival. Mice infected intranasally with the DELTActu mutant show significantly reduced bacterial burden in the lungs, liver, and spleen compared to wild-type Schu S4-infected mice.