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3.5.1.2: glutaminase

This is an abbreviated version!
For detailed information about glutaminase, go to the full flat file.

Word Map on EC 3.5.1.2

Reaction

L-glutamine
+
H2O
=
L-glutamate
 +
NH3

Synonyms

AnsB, AoGls, GA, GAB, GAC, GahB, GLA, GLNase, GLS, GLS1, GLS2, GlsA, glutaminase, glutaminase 1, glutaminase 2, glutaminase A, glutaminase B, glutaminase C, glutaminase I, glutaminase K, glutaminase L, glutaminase-1, glutaminase-2, glutaminase-B, glutamine amidohydrolase, glutamine aminohydrolase, glutamine deamidating enzyme, K-glutaminase, KAG, KGA, kidney-type glutaminase, kidney-type-glutaminase, L-glutaminase, L-glutamine amidohydrolase, LAG, LGA, liver-type glitaminase, liver-type glutaminase, Mglu, Micrococcus glutaminase Mglu, Micrococcus luteus K-3-type glutaminase, mitochondrial glutaminase, N-PAG, neuroblastoma glutaminase, neuroblastoma PAG, Nit 2, nitrilase 2, omega-amidase, PAG, PDX2, phosphate activated glutaminase, phosphate-activated glutaminase, phosphate-activated L-glutamine amidohydrolase, salt-tolerant glutaminase, YaaE

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.2 glutaminase

IC50 Value

IC50 Value on EC 3.5.1.2 - glutaminase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0231 - 0.05
(2R)-1-(2-formyl-3,6-dihydroxy-5-methoxycyclohexa-1,4-dien-1-yl)tridecan-2-yl acetate
0.0251 - 0.05
(2R)-1-(2-hydroxy-5-methoxy-3,6-dioxocyclohexa-1,4-dien-1-yl)pentadecan-2-yl acetate
0.05 - 0.5
(2R)-1-(2-hydroxy-5-methoxy-3,6-dioxocyclohexa-1,4-dien-1-yl)tridecan-2-yl acetate
0.00026 - 0.0029
(2R)-1-(3,6-dihydroxy-5-methoxycyclohexa-1,4-dien-1-yl)tridecan-2-yl acetate
0.00028 - 0.0021
(2R)-1-(5-methoxy-3,6-dioxocyclohexa-1,4-dien-1-yl)pentadecan-2-yl acetate
0.00029 - 0.0039
(2R)-1-(5-methoxy-3,6-dioxocyclohexa-1,4-dien-1-yl)tridecan-2-yl acetate
0.0057 - 0.069
(2R)-1-[3-(acetyloxy)-6-hydroxy-5-methoxycyclohexa-1,4-dien-1-yl]pentadecan-2-yl acetate
0.0317 - 0.05
(2R)-1-[3-(acetyloxy)-6-hydroxy-5-methoxycyclohexa-1,4-dien-1-yl]tridecan-2-yl acetate
0.05 - 0.0527
(2S)-1-(5-methoxycyclohexa-1,4-dien-1-yl)heptan-2-ol
0.05 - 0.5
2-hydroxy-5-methoxy-3-tridecylcyclohexa-2,5-diene-1,4-dione
0.05 - 0.5
2-methoxy-6-pentadecylcyclohexa-2,5-diene-1,4-dione
0.0325 - 0.5
2-methoxy-6-tridecylcyclohexa-2,5-diene-1,4-dione
0.0027 - 0.0769
2-methyl-5-[(7Z)-pentadec-7-en-1-yl]cyclohexa-1,4-diene-1,3-diol
0.05 - 0.0598
2-methyl-5-[(7Z)-tridec-7-en-1-yl]cyclohexa-1,4-diene-1,3-diol
0.1
2-phenyl isoindolin-1-one
Mus musculus
-
IC50 above 0.1 mM, pH and temperature not specified in the publication
0.02
2-phenylbenzo[d] isoxazol-3(2H)-one
Mus musculus
-
pH and temperature not specified in the publication
0.0076 - 0.0524
3-[(2S)-2-hydroxypentadecyl]-5-methoxycyclohexa-2,5-dien-1-ol
0.0047 - 0.041
4-hydroxy-2-methoxy-6-(2-oxopentadecyl)cyclohexa-2,5-dien-1-yl acetate
0.1
5,5'-(sulfanediyldiethane-2,1-diyl)bis(1,3,4-thiadiazol-2-amine)
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.0031 - 0.0139
5-[(6Z)-13-(3,5-dihydroxy-4-methylcyclohexa-1,4-dien-1-yl)tridec-6-en-1-yl]-2-methylbenzene-1,3-diol
0.0021 - 0.0117
5-[(6Z)-13-(3,5-dihydroxy-4-methylcyclohexa-1,4-dien-1-yl)tridec-6-en-1-yl]benzene-1,3-diol
0.0029 - 0.0096
5-[(6Z)-13-(3-hydroxy-5-methoxycyclohexa-1,4-dien-1-yl)tridec-6-en-1-yl]benzene-1,3-diol
0.0025 - 0.0367
5-[(7Z)-13-(3-hydroxy-5-methoxyphenyl)tridec-7-en-1-yl]-2-methylcyclohexa-1,4-diene-1,3-diol
0.0023 - 0.07
5-[(7Z)-15-(3-hydroxy-5-methoxyphenyl)pentadec-7-en-1-yl]-2-methylcyclohexa-1,4-diene-1,3-diol
0.0029 - 0.073
5-[(7Z)-pentadec-7-en-1-yl]cyclohexa-1,4-diene-1,3-diol
0.0028 - 0.0765
5-[(7Z)-tridec-7-en-1-yl]cyclohexa-1,4-diene-1,3-diol
0.0029 - 0.0175
5-[(8Z)-15-(3,5-dihydroxy-4-methylcyclohexa-1,4-dien-1-yl)pentadec-8-en-1-yl]-2-methylbenzene-1,3-diol
0.0023 - 0.0119
5-[(8Z)-15-(3,5-dihydroxy-4-methylcyclohexa-1,4-dien-1-yl)pentadec-8-en-1-yl]benzene-1,3-diol
0.0029 - 0.0134
5-[(8Z)-15-(3-hydroxy-5-methoxycyclohexa-1,4-dien-1-yl)pentadec-8-en-1-yl]benzene-1,3-diol
0.0028 - 0.0144
5-[14-(3-hydroxy-5-methoxycyclohexa-1,4-dien-1-yl)tetradecyl]benzene-1,3-diol
0.0014
5-[5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]-N-[2-(4-phenylpiperidin-1-yl)ethyl]pentanamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.01
5-[5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]-N-[2-(piperidin-1-yl)ethyl]pentanamide
Homo sapiens
IC50 above 0.1 mM, in 45 mM phosphate buffer (pH 8.2), at 22°C
0.0046
5-[5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]-N-[2-(pyrrolidin-1-yl)ethyl]pentanamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.1
5-[5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]-N-[4-(trifluoromethyl)benzyl]pentanamide
Homo sapiens
IC50 above 0.1 mM, in 45 mM phosphate buffer (pH 8.2), at 22°C
0.0599
6-diazo-5-oxo-L-norleucine
Homo sapiens
-
isoform KGA, at pH 8.6 and 37°C
0.0006
apomorphine
Mus musculus
-
pH and temperature not specified in the publication
0.1
Berberine
Mus musculus
-
IC50 above 0.1 mM, pH and temperature not specified in the publication
0.00006 - 0.1
bis-2-(5-phenylacetimido-1,2,4,thiadiazol-2-yl)ethyl sulfide
0.00008 - 0.0636
bis-2-(5-phenylacetimido-1,2,4-thiadiazol-2-yl) ethyl sulfide
0.00003
chelerythrine
Mus musculus
-
pH and temperature not specified in the publication
0.000009
ebselen
Mus musculus
-
pH and temperature not specified in the publication
0.2 - 5.5
Mg2+
0.1 - 1.3
Mn2+
0.0033
N,N'-[sulfanediylbis(ethane-2,1-diyl-1,3,4-thiadiazole-5,2-diyl)]bis(2-phenylacetamide)
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.1
N-(2-aminoethyl)-5-[5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]pentanamide
Homo sapiens
IC50 above 0.1 mM, in 45 mM phosphate buffer (pH 8.2), at 22°C
0.0027
N-(5-[2-[2-(5-amino-[1,3,4]thiadiazol-2-yl)-ethylsulfanyl]-ethyl]-[1,3,4]thiadiazol-2-yl)-2-phenyl-acetamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.1
N-benzyl-5-[5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]pentanamide
Homo sapiens
IC50 above 0.1 mM, in 45 mM phosphate buffer (pH 8.2), at 22°C
0.1
N-methyl-5-[5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]-N-[2-(pyrrolidin-1-yl)ethyl]pentanamide
Homo sapiens
IC50 above 0.1 mM, in 45 mM phosphate buffer (pH 8.2), at 22°C
0.011
N-tert-butyl-5-[5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]pentanamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.0052
N-tert-butyl-N-methyl-5-[5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]pentanamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.0081
N-[2-(1-methylpyrrolidin-2-yl)ethyl]-5-[5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]pentanamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.0038
N-[2-(4-hydroxypiperidin-1-yl)ethyl]-5-[5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]pentanamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.026
N-[2-(diethylamino)ethyl]-5-[5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]pentanamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.048
N-[4-(dimethylamino)benzyl]-5-[5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]pentanamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.1
N-[4-[4-(5-amino-1,3,4-thiadiazol-2-yl)butyl]-1,3-thiazol-2-yl]-2-phenylacetamide
Homo sapiens
IC50 above 0.1 mM, in 45 mM phosphate buffer (pH 8.2), at 22°C
0.061
N-[5-(2-[[2-(5-amino-1,3,4-thiadiazol-2-yl)ethyl]sulfinyl]ethyl)-1,3,4-thiadiazol-2-yl]-2-phenylacetamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.015
N-[5-[2-(5-amino-1,3,4-thiadiazol-2-yl)ethyl]-1,3,4-thiadiazol-2-yl]-2-phenylacetamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.0026
N-[5-[4-(5-amino-1,3,4-thiadiazol-2-yl)butyl]-1,3,4-thiadiazol-2-yl]-2-(4-fluorophenyl)acetamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.0045
N-[5-[4-(5-amino-1,3,4-thiadiazol-2-yl)butyl]-1,3,4-thiadiazol-2-yl]-2-(4-methylphenyl)acetamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.022
N-[5-[4-(5-amino-1,3,4-thiadiazol-2-yl)butyl]-1,3,4-thiadiazol-2-yl]-2-cyclohexylacetamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.0019
N-[5-[4-(5-amino-1,3,4-thiadiazol-2-yl)butyl]-1,3,4-thiadiazol-2-yl]-2-phenylacetamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.012
N-[5-[4-(5-amino-1,3,4-thiadiazol-2-yl)butyl]-1,3,4-thiadiazol-2-yl]-2-phenylpropanamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.1
N-[5-[4-(5-amino-1,3,4-thiadiazol-2-yl)butyl]-1,3,4-thiadiazol-2-yl]-3-phenylpropanamide
Homo sapiens
IC50 above 0.1 mM, in 45 mM phosphate buffer (pH 8.2), at 22°C
0.0072
N-[5-[4-(5-amino-1,3,4-thiadiazol-2-yl)butyl]-1,3,4-thiadiazol-2-yl]benzamide
Homo sapiens
in 45 mM phosphate buffer (pH 8.2), at 22°C
0.1
N-[5-[4-(5-amino-1,3,4-thiadiazol-2-yl)butyl]-1,3-thiazol-2-yl]-2-phenylacetamide
Homo sapiens
IC50 above 0.1 mM, in 45 mM phosphate buffer (pH 8.2), at 22°C
39
Ngamma,Ngamma-diethyl-L-glutamine
Escherichia coli
-
37°C, pH 7.5
35
Ngamma,Ngamma-dimethyl-L-glutamine
Escherichia coli
-
37°C, pH 7.5
24
Ngamma-ethyl-L-glutamine
Escherichia coli
-
37°C, pH 7.5
20
Ngamma-methyl-L-glutamine
Escherichia coli
-
37°C, pH 7.5
0.009
nitidine
Mus musculus
-
pH and temperature not specified in the publication
0.1
norsanguinarine
Mus musculus
-
IC50 above 0.1 mM, pH and temperature not specified in the publication
17.2 - 17.4
PO43-
Escherichia coli
-
0.004
R(-)-apocodeine
Mus musculus
-
pH and temperature not specified in the publication
0.0009
R(-)-propylnorapomorphine
Mus musculus
-
pH and temperature not specified in the publication
0.0001
sanguinarine
Mus musculus
-
pH and temperature not specified in the publication