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3.5.1.2: glutaminase

This is an abbreviated version!
For detailed information about glutaminase, go to the full flat file.

Word Map on EC 3.5.1.2

Reaction

L-glutamine
+
H2O
=
L-glutamate
 +
NH3

Synonyms

AnsB, AoGls, GA, GAB, GAC, GahB, GLA, GLNase, GLS, GLS1, GLS2, GlsA, glutaminase, glutaminase 1, glutaminase 2, glutaminase A, glutaminase B, glutaminase C, glutaminase I, glutaminase K, glutaminase L, glutaminase-1, glutaminase-2, glutaminase-B, glutamine amidohydrolase, glutamine aminohydrolase, glutamine deamidating enzyme, K-glutaminase, KAG, KGA, kidney-type glutaminase, kidney-type-glutaminase, L-glutaminase, L-glutamine amidohydrolase, LAG, LGA, liver-type glitaminase, liver-type glutaminase, Mglu, Micrococcus glutaminase Mglu, Micrococcus luteus K-3-type glutaminase, mitochondrial glutaminase, N-PAG, neuroblastoma glutaminase, neuroblastoma PAG, Nit 2, nitrilase 2, omega-amidase, PAG, PDX2, phosphate activated glutaminase, phosphate-activated glutaminase, phosphate-activated L-glutamine amidohydrolase, salt-tolerant glutaminase, YaaE

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.2 glutaminase

Activating Compound

Activating Compound on EC 3.5.1.2 - glutaminase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
slight activation
2-mercaptoethanol
-
138.22% activity at 100 mM
angiotensin II
-
activates
citrate
-
enhances activity
CTP
-
activates enzyme from mesenteric lymph nodes
cysteine
-
128.15% activity at 100 mM
D-fructose 6-phosphate
-
activates enzyme from mesenteric lymph nodes
D-glucose 6-phosphate
-
activates enzyme from mesenteric lymph nodes
dithiothreitol
EDTA
-
slight activation
Epidermal growth factor
-
kidney-type glutaminase activity in cells is stimulated by EGF
glucagon
-
activates
glutathione
-
129.32% activity at 100 mM
glyoxylate
-
50 mM, increasing enzyme activity by 30%
GTP
-
activates enzyme from mesenteric lymph nodes
HCO3-
-
activates
ITP
-
activates enzyme from mesenteric lymph nodes
L-ascorbic acid
-
128.23% activity at 100 mM
L-glutamine
enhanced enzyme activity in jejunal mucosa
Lactate
-
enhances activity
Leu
-
activates enzyme from mesenteric lymph nodes, 50% activation at 0.6 mM
malate
-
enhances activity
NaCl
-
2.5%, 130% of initial activity, 10%, 109% of initial activity
oxaloacetate
-
50 mM, increasing enzyme activity by 30%
phosphate
phosphoenolpyruvate
-
activates enzyme from mesenteric lymph nodes, 50% activation at 0.2 mM
sulfate
Tris
activates Mglu by approximately 6fold at pH 7.5
additional information
-
strong stimulation of glutaminase subunit TrpG activity by the associated synthase subunit TrpE within the glutamine amidotransferase, GATase, enzyme complex
-