3.5.1.15: aspartoacylase

This is an abbreviated version!
For detailed information about aspartoacylase, go to the full flat file.

Word Map on EC 3.5.1.15

3.5.1.15

canavan

n-acetylaspartate

leukodystrophy

matter

myelin

oligodendrocyte

spongy

n-acetyl-l-aspartate

spongiform

macrocephaly

tremor

ashkenazi

jewish

non-jewish

dysmyelination

nutrition

medicine

pharmacology

n-acetylaspartylglutamate

triacetate

Reaction

Synonyms

acetyl-aspartic deaminase, Acylase II, aminoacylase 2, Aminoacylase II, aminoacylase-2, ASPA, aspartic acid acylase, Aspartoacylase, aspartoacylase II, hASPA, human ASPA, More, murine aspartoacylase, N-acetyl-aspartate deacetylase, N-Acetyl-L-aspartate amidohydrolase, N-Acetylaspartate amidohydrolase, N-acetylaspartocylase, NAA acylase

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.1.15 aspartoacylase

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Results	in table
26	Activating Compound
712	AA Sequence
7	Application
1	CAS Registry Number
17	Cloned(Commentary)
5	Crystallization (Commentary)
540	Disease/ Diagnostics
1	Expression
15	General Information
3	General Stability
14	Inhibitors
5	kcat/KM [mM/s]
1	Ki Value [mM]
25	KM Value [mM]
16	Localization
16	Metals/Ions
12	Molecular Weight [Da]
60	Natural Substrates/ Products (Substrates)
255	Organism
1	Oxidation Stability
3	Pathway
20	PDB ID
8	pH Optimum
1	pH Range
2	Posttranslational Modification
65	Protein Variants
16	Purification (Commentary)
2	Reaction
1	Reaction Type
73	Reference
1	Renatured (Commentary)
110	Source Tissue
11	Specific Activity [micromol/min/mg]
4	Storage Stability
164	Substrates and Products (Substrate)
11	Subunits
51	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Temperature Stability [°C]
13	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.5.1.15 - aspartoacylase

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chloroacetylamino acids

dithiothreitol

enhances activity

N-acetylaspartate

N-acetylaspartate acts as activator at low concentrations, substrate at moderate concentrations, and inhibitor at high concentrations

NP-40

enhances activity

Triton X-100

Tween-20

enhances activity

additional information

Mus musculus

upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse

667443