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3.4.25.1: proteasome endopeptidase complex

This is an abbreviated version!
For detailed information about proteasome endopeptidase complex, go to the full flat file.

Word Map on EC 3.4.25.1

Reaction

cleavage of peptide bonds with very broad specificity =

Synonyms

20 S proteasome, 206 proteasome, 20S CP, 20S protease core, 20S proteasome, 26 S proteasome, 26S protease, 26S proteasome, 26S proteasome complex, 27 kDa prosomal protein, 30 kDa prosomal protein, beta1-PF1404, c20S, Component Y8, constitutive proteasome 20S, EC 3.4.22.21, EC 3.4.24.5, EC 3.4.99.46, GPRO-28, HsBPROS26, HSN3, i20S, immunoproteasome 20S, ingensin, KIPase, large multicatalytic protease, macropain, multi-subunit protease complex, multicatalytic endopeptidase complex, Multicatalytic endopeptidase complex C7, multicatalytic protease, multicatalytic proteinase, p27K, PROS-27, PROS-30, PROS-Dm25, PROS-Dm28.1, PROS-Dm29, PROS-Dm35, Pros26.4, prosome, proteasome, proteasome 19S, proteasome 20S, Proteasome component C13, Proteasome component C2, Proteasome component C3, Proteasome component C5, Proteasome component C8, Proteasome component C9, Proteasome component DD4, Proteasome component DD5, Proteasome component pts1, proteasome subunit alpha-type 7-like, PSMA5, Psma8, RING12 protein, RN3, Scl1, SCL1 suppressor protein, SFRICE_003436, T20S, TAS-F22/FAFP98, TAS-G64, TCPR29, tricorn protease, tricorn proteinase, XC3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.25 Threonine endopeptidases
                3.4.25.1 proteasome endopeptidase complex

KM Value

KM Value on EC 3.4.25.1 - proteasome endopeptidase complex

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0042
ABZ-Val-Val-Ser-(4-guanidino-Phe)-Ala-Met-Gly-Tyr(3-NO2)-NH2
-
20S proteasome, pH 8.2, 37°C
0.0177
ABZ-Val-Val-Ser-Arg-Ser-Leu-Gly-Tyr(3-NO2)-NH2
-
20S proteasome, pH 8.2, 37°C
0.0094
acetyl-Arg-hSer-Thr-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.051
acetyl-betaAla-Met(sulfone)-Thr-Arg-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.032 - 0.088
acetyl-EPFD-7-amido-4-carbamoylcoumarin
0.0159
acetyl-hArg-Pro-2-fluoro-Phe-Asp-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.0432
acetyl-hArg-Pro-Abu-Asp-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.36
acetyl-HHSL-7-amido-4-carbamoylcoumarin
-
pH 7.5, 25°C
0.11 - 0.67
acetyl-norleucine-Arg-norleucine-Arg-7-amido-4-carbamoylcoumarin
0.027 - 0.038
acetyl-YWTQ-7-amido-4-carbamoylcoumarin
0.1
benzoyl-VGR-7-amido-4-methylcoumarin
-
-
0.248
benzyloxycarbonyl-ARR-7-amido-4-methylcoumarin
-
-
2.29
benzyloxycarbonyl-GGF-4-aminobenzoate
-
enzyme from thymus
0.751
benzyloxycarbonyl-GGL-7-amido-4-methylcoumarin
-
-
0.798
benzyloxycarbonyl-GGR-7-amido-4-methylcoumarin
-
-
0.38 - 3.3
benzyloxycarbonyl-GPAFG-4-aminobenzoate
0.14 - 0.57
benzyloxycarbonyl-GPALG-4-aminobenzoate
0.048
benzyloxycarbonyl-Leu-Leu-Leu-7-amido-4-methylcoumarin
-
-
0.255
benzyloxycarbonyl-LLE-2-naphthylamide
-
-
0.12
benzyloxycarbonyl-LLE-7-amido-4-methylcoumarin
-
-
0.051
benzyloxycarbonyl-RR-7-amido-4-methylcoumarin
-
-
0.01054
beta-casein
-
at 37°C
-
0.07
N-succinyl-LLVY 7-amido-4-methylcoumarin
-
-
1.504
succinyl-AAF-7-amido-4-methylcoumarin
-
-
0.089
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin
-
-
0.263
succinyl-LLVY-7-amido-4-methylcoumarin
-
-
0.2
tert-butyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin
-
-