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3.4.24.73: jararhagin

This is an abbreviated version!
For detailed information about jararhagin, go to the full flat file.

Word Map on EC 3.4.24.73

Reaction

Hydrolysis of -His10-/-Leu-, -Ala14-/-Leu-, -Tyr16-/-Leu-and -Phe24-/-Phe- bonds in insulin B chain =

Synonyms

haemolytic factor-2, hemorrhagic svMP, HF2, HF2-proteinase, Jar, Jar-C, jararafibrase 1, jararhagin, jararhagin-c, JF1, JG, More, PIII snake venom metalloprotease, PIII snake venom metalloproteinase, PIII SVMP, rCDJARA, snake venom metalloproteinase, snake venom metalloproteinase-disintegrin, soluble haemorrhagic snake venom metalloproteinase, SVMP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.73 jararhagin

Reference

Reference on EC 3.4.24.73 - jararhagin

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mandelbaum, F.R.; Reichl, A.P.; Assakura, M.T.
Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca
Anim. Plant Microb. Toxins (Proc. Int. Symp. ,4th, Meeting Date 1974) (Ohsaka, A. , Hayashi, K. , Sawai, Y. , eds. ) Plenum Press, N. Y.
1
111-121
1976
Bothrops jararaca
-
Manually annotated by BRENDA team
Assakura, A.T.; Reichl, A.P.; Mandelbaum, F.R.
Comparison of immunological, biochemical and biophysical properties of three hemorrhagic factors isolated from the venom of Bothrops jararaca (jararaca)
Toxicon
24
943-946
1986
Bothrops jararaca
Manually annotated by BRENDA team
Paine, M.J.I.; Desmond, H.P.; Theakston, R.D.G.; Crampton, J.M.
Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family
J. Biol. Chem.
267
22869-22876
1992
Bothrops jararaca
Manually annotated by BRENDA team
Sugiki, M.; Maruyama, M.; Yoshida, E.; Mihara, H.; Kamiguti, A.S.; Theakston, R.D.G.
Enhancement of plasma fibrinolysis in vitro by jararhagin, the main haemorrhagic metalloproteinase in Bothrops jararaca venom
Toxicon
33
1605-1617
1995
Bothrops jararaca
Manually annotated by BRENDA team
Maruyama, M.; Sugiki, M.; Yoshida, E.; Mihara, H.; Nakajima, N.
Purification and characterization of two fibrinolytic enzymes from Bothrops jararaca (jararaca) venom
Toxicon
30
853-864
1992
Bothrops jararaca
Manually annotated by BRENDA team
Kamiguti, A.S.; Desmond, H.P.; Theakston, R.D.G.; Hay, C.R.M.; Zuzel, M.
Ineffectiveness of the inhibition of the main haemorrhagic metalloproteinase from Bothrops jararaca venom by its only plasma inhibitor, alpha 2-macroglobulin
Biochim. Biophys. Acta
1200
307-314
1994
Bothrops jararaca
Manually annotated by BRENDA team
Souza, D.H.; Selistre-de-Araujo, H.S.; Moura-da-Silva, A.M.; Della-Casa, M.S.; Oliva, G.; Garratt, R.C.
Crystallization and preliminary X-ray analysis of jararhagin, a metalloproteinase/disintegrin from Bothrops jararaca snake venom
Acta Crystallogr. Sect. D
57
1135-1137
2001
Bothrops jararaca
Manually annotated by BRENDA team
Zigrino, P.; Kamiguti, A.S.; Eble, J.; Drescher, C.; Nischt, R.; Fox, J.W.; Mauch, C.
The reprolysin jararhagin, a snake venom metalloproteinase, functions as a fibrillar collagen agonist involved in fibroblast cell adhesion and signaling
J. Biol. Chem.
277
40528-40535
2002
Bothrops jararaca
Manually annotated by BRENDA team
Tanjoni, I.; Weinlich, R.; Della-Casa, M.S.; Clissa, P.B.; Saldanha-Gama, R.F.; de Freitas, M.S.; Barja-Fidalgo, C.; Amarante-Mendes, G.P.; Moura-da-Silva, A.M.
Jararhagin, a snake venom metalloproteinase, induces a specialized form of apoptosis (anoikis) selective to endothelial cells
Apoptosis
10
851-861
2005
Bothrops jararaca
Manually annotated by BRENDA team
Gallagher, P.; Bao, Y.; Serrano, S.M.; Laing, G.D.; Theakston, R.D.; Gutierrez, J.M.; Escalante, T.; Zigrino, P.; Moura-da-Silva, A.M.; Nischt, R.; Mauch, C.; Moskaluk, C.; Fox, J.W.
Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: in vitro and in vivo gene expression analysis of the effects of the toxin
Arch. Biochem. Biophys.
441
1-15
2005
Bothrops jararaca
Manually annotated by BRENDA team
Schattner, M.; Fritzen, M.; Ventura, J.d.e.S.; de Albuquerque Modesto, J.C.; Pozner, R.G.; Moura-da-Silva, A.M.; Chudzinski-Tavassi, A.M.
The snake venom metalloproteases berythractivase and jararhagin activate endothelial cells
Biol. Chem.
386
369-374
2005
Bothrops jararaca
Manually annotated by BRENDA team
Garcia, L.T.; Parreiras e Silva, L.T.; Ramos, O.H.; Carmona, A.K.; Bersanetti, P.A.; Selistre-de-Araujo, H.S.
The effect of post-translational modifications on the hemorrhagic activity of snake venom metalloproteinases
Comp. Biochem. Physiol. C
138
23-32
2004
Bothrops jararaca
Manually annotated by BRENDA team
Laing, G.D.; Paine, M.J.
Jararhagin
Handbook of Proteolytic Enzymes (Barrett,A. J. ;Rawlings,N. D. ,Woessner)
1
654-656
2004
Bothrops jararaca
-
Manually annotated by BRENDA team
Costa, E.P.; Santos, M.F.
Jararhagin, a snake venom metalloproteinase-disintegrin, stimulates epithelial cell migration in an in vitro restitution model
Toxicon
44
861-870
2004
Bothrops jararaca
Manually annotated by BRENDA team
Laing, G.D.; Moura-da-Silva, A.M.
Jararhagin and its multiple effects on hemostasis
Toxicon
45
987-996
2005
Bothrops jararaca
Manually annotated by BRENDA team
Clissa, P.B.; Lopes-Ferreira, M.; Della-Casa, M.S.; Farsky, S.H.; Moura-da-Silva, A.M.
Importance of jararhagin disintegrin-like and cysteine-rich domains in the early events of local inflammatory response
Toxicon
47
591-596
2006
Bothrops jararaca
Manually annotated by BRENDA team
Pereira, A.L.; Fritzen, M.; Faria, F.; da Motta, G.; Chudzinski-Tavassi, A.M.
Releasing or expression modulating mediator involved in hemostasis by Berythractivase and Jararhagin (SVMPs)
Toxicon
47
788-796
2006
Bothrops jararaca
Manually annotated by BRENDA team
Escalante, T.; Shannon, J.; Moura-da-Silva, A.M.; Gutierrez, J.M.; Fox, J.W.
Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study
Arch. Biochem. Biophys.
455
144-153
2006
Bothrops jararaca
Manually annotated by BRENDA team
Pinto, A.F.; Terra, R.M.; Guimaraes, J.A.; Fox, J.W.
Mapping von Willebrand factor A domain binding sites on a snake venom metalloproteinase cysteine-rich domain
Arch. Biochem. Biophys.
457
41-46
2007
Bothrops jararaca
Manually annotated by BRENDA team
Moura-da-Silva, A.M.; Ramos, O.H.; Baldo, C.; Niland, S.; Hansen, U.; Ventura, J.S.; Furlan, S.; Butera, D.; Della-Casa, M.S.; Tanjoni, I.; Clissa, P.B.; Fernandes, I.; Chudzinski-Tavassi, A.M.; Eble, J.A.
Collagen binding is a key factor for the hemorrhagic activity of snake venom metalloproteinases
Biochimie
90
484-492
2008
Bothrops jararaca (P30431)
Manually annotated by BRENDA team
Serrano, S.M.; Wang, D.; Shannon, J.D.; Pinto, A.F.; Polanowska-Grabowska, R.K.; Fox, J.W.
Interaction of the cysteine-rich domain of snake venom metalloproteinases with the A1 domain of von Willebrand factor promotes site-specific proteolysis of von Willebrand factor and inhibition of von Willebrand factor-mediated platelet aggregation
FEBS J.
274
3611-3621
2007
Bothrops jararaca
Manually annotated by BRENDA team
Serrano, S.M.; Kim, J.; Wang, D.; Dragulev, B.; Shannon, J.D.; Mann, H.H.; Veit, G.; Wagener, R.; Koch, M.; Fox, J.W.
The cysteine-rich domain of snake venom metalloproteinases is a ligand for von Willebrand factor A domains: role in substrate targeting
J. Biol. Chem.
281
39746-39756
2006
Bothrops jararaca
Manually annotated by BRENDA team
Francisco, G.; Zara, F.J.; Maria, D.A.; Cruz-Neto, A.P.
Toxin jararhagin in low doses induces interstitial edema and increases the metabolic rate and red blood cells in mice
Toxicon
48
1060-1067
2006
Bothrops jararaca
Manually annotated by BRENDA team
Baldo, C.; Tanjoni, I.; Leon, I.R.; Batista, I.F.; Della-Casa, M.S.; Clissa, P.B.; Weinlich, R.; Lopes-Ferreira, M.; Lebrun, I.; Amarante-Mendes, G.P.; Rodrigues, V.M.; Perales, J.; Valente, R.H.; Moura-da-Silva, A.M.
BnP1, a novel P-I metalloproteinase from Bothrops neuwiedi venom: biological effects benchmarking relatively to jararhagin, a P-III SVMP
Toxicon
51
54-65
2008
Bothrops jararaca
Manually annotated by BRENDA team
Lambert, L.J.; Bobkov, A.A.; Smith, J.W.; Marassi, F.M.
Competitive interactions of collagen and a jararhagin-derived disintegrin peptide with the integrin alpha2-I domain
J. Biol. Chem.
283
16665-16672
2008
Bothrops jararaca
Manually annotated by BRENDA team
Costa, E.P.; Del Debbio, C.B.; Cintra, L.C.; da Fontoura Costa, L.; Hamassaki, D.E.; Santos, M.F.
Jararhagin, a snake venom metalloprotease-disintegrin, activates the Rac1 GTPase and stimulates neurite outgrowth in neuroblastoma cells
Toxicon
52
380-384
2008
Bothrops jararaca
Manually annotated by BRENDA team
Tanjoni, I.; Evangelista, K.; Della-Casa, M.S.; Butera, D.; Magalhaes, G.S.; Baldo, C.; Clissa, P.B.; Fernandes, I.; Eble, J.; Moura-da-Silva, A.M.
Different regions of the class P-III snake venom metalloproteinase jararhagin are involved in binding to alpha2beta1 integrin and collagen
Toxicon
55
1093-1099
2010
Bothrops jararaca
Manually annotated by BRENDA team
Baldo, C.; Jamora, C.; Yamanouye, N.; Zorn, T.M.; Moura-da-Silva, A.M.
Mechanisms of vascular damage by hemorrhagic snake venom metalloproteinases: tissue distribution and in situ hydrolysis
PLoS Negl. Trop. Dis.
4
e727
2010
Bothrops jararaca (P30431)
Manually annotated by BRENDA team
Klein, A.; Capitanio, J.S.; Maria, D.A.; Ruiz, I.R.
Gene expression in SK-Mel-28 human melanoma cells treated with the snake venom jararhagin
Toxicon
57
1-8
2011
Bothrops jararaca (P30431), Bothrops jararaca
Manually annotated by BRENDA team
Ferreira, B.A.; Deconte, S.R.; de Moura, F.B.R.; Tomiosso, T.C.; Clissa, P.B.; Andrade, S.P.; Araujo, F.A.
Inflammation, angiogenesis and fibrogenesis are differentially modulated by distinct domains of the snake venom metalloproteinase jararhagin
Int. J. Biol. Macromol.
119
1179-1187
2018
Bothrops jararaca (P30431), Bothrops jararaca
Manually annotated by BRENDA team
Baldo, C.; Lopes, D.S.; Faquim-Mauro, E.L.; Jacysyn, J.F.; Niland, S.; Eble, J.A.; Clissa, P.B.; Moura-da-Silva, A.M.
Jararhagin disruption of endothelial cell anchorage is enhanced in collagen enriched matrices
Toxicon
108
240-248
2015
Bothrops jararaca
Manually annotated by BRENDA team