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3.4.24.72: fibrolase

This is an abbreviated version!
For detailed information about fibrolase, go to the full flat file.

Word Map on EC 3.4.24.72

Reaction

Hydrolysis of -Ala14-/-Leu- in insulin B chain and -Lys413-/-Leu- in Aalpha-chain of fibrinogen =

Synonyms

3-203-fibrolase[3-serine], AfeE, Agkistrodon contortrix contortrix metalloproteinase, ALF, Alfimeprase, brevilysin L6, brevithrombolase, broad bean-fibrinolytic enzyme, CFR15-protease, fibrinolytic enzyme, fibrinolytic protease, Fibrinolytic proteinase, FIIa, neuwiedase, Non-hemorrhagic fibrinolytic metalloproteinase, plasmin, Proteinase, Agkistrodon contortrix contortrix venom metallo-, snake venom fibrinolytic enzyme, starase, UFEIII, VlF, wulfase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.72 fibrolase

pH Range

pH Range on EC 3.4.24.72 - fibrolase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 10
-
considerable activity is observed at pH 10.0 (84.4%). The enzyme exhibits poorer activity in the acidic pH 5.0-6.0 (53-64%)
5 - 9
-
more than 60% activity between pH 5.0 and 9.0, about 40% activity at pH 10.0, no activity at pH 4.0
5.2 - 8.8
-
more than 60% activity between pH 5.2 and 8.8
5.5 - 11
-
the enzyme is active between pH 5.5 and 11.0
6 - 10
-
more than 50% activity between pH 6.0 and 10.0
6 - 12
the enzyme shows more than 60% activity at pH values ranging from 6.0 to 12.0
7 - 10
Serratia sp. KG-2-1
-
highly active between pH 7.0 and 10.0
7 - 8
-
the enzyme activity decreases rapidly at levels below pH 7.0 and above pH 8.0
8.5 - 9.5
-
-