3.4.24.72: fibrolase
This is an abbreviated version!
For detailed information about fibrolase, go to the full flat file.
Word Map on EC 3.4.24.72
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3.4.24.72
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plasmin
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thrombolytic
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copperhead
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fibrinogenolytic
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medicine
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nonhemorrhagic
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neuwiedi
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alteplase
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pharmacology
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drug development
- 3.4.24.72
- plasmin
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thrombolytic
- copperhead
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fibrinogenolytic
- medicine
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nonhemorrhagic
- neuwiedi
- alteplase
- pharmacology
- drug development
Reaction
Hydrolysis of -Ala14-/-Leu- in insulin B chain and -Lys413-/-Leu- in Aalpha-chain of fibrinogen =
Synonyms
3-203-fibrolase[3-serine], AfeE, Agkistrodon contortrix contortrix metalloproteinase, ALF, Alfimeprase, brevilysin L6, brevithrombolase, broad bean-fibrinolytic enzyme, CFR15-protease, fibrinolytic enzyme, fibrinolytic protease, Fibrinolytic proteinase, FIIa, neuwiedase, Non-hemorrhagic fibrinolytic metalloproteinase, plasmin, Proteinase, Agkistrodon contortrix contortrix venom metallo-, snake venom fibrinolytic enzyme, starase, UFEIII, VlF, wulfase
ECTree
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Subunits
Subunits on EC 3.4.24.72 - fibrolase
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monomer
additional information
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x * 23000-24000, Agkistrodon contortrix, SDS-PAGE under reducing and nonreducing condition
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x * 23800, recombinant His-tagged alfimeprase, SDS-PAGE
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x * 42000, the enzyme exists in three isoforms of 42000, 48000 and 60000 Da, SDS-PAGE
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x * 48000, the enzyme exists in three isoforms of 42000, 48000 and 60000 Da, SDS-PAGE
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x * 60000, the enzyme exists in three isoforms of 42000, 48000 and 60000 Da, SDS-PAGE
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x * 42000, the enzyme exists in three isoforms of 42000, 48000 and 60000 Da, SDS-PAGE
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?
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x * 48000, the enzyme exists in three isoforms of 42000, 48000 and 60000 Da, SDS-PAGE
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?
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x * 60000, the enzyme exists in three isoforms of 42000, 48000 and 60000 Da, SDS-PAGE
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alfimeprase is the recombinant truncated form of fibrolase from snake venom lacking the two N-terminal amino acids Glu and Gln, fibrolase N-terminus: SFPQR, alfimeprase N-terminus: EQRFPQR
additional information
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the protein is composed of 5 alpha-helical regions, 4 parallel and 1 antiparallel beta-sheet, stablized by 3 disulfide bonds