3.4.24.72: fibrolase
This is an abbreviated version!
For detailed information about fibrolase, go to the full flat file.
Word Map on EC 3.4.24.72
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3.4.24.72
-
plasmin
-
thrombolytic
-
copperhead
-
fibrinogenolytic
-
medicine
-
nonhemorrhagic
-
neuwiedi
-
alteplase
-
pharmacology
-
drug development
- 3.4.24.72
- plasmin
-
thrombolytic
- copperhead
-
fibrinogenolytic
- medicine
-
nonhemorrhagic
- neuwiedi
- alteplase
- pharmacology
- drug development
Reaction
Hydrolysis of -Ala14-/-Leu- in insulin B chain and -Lys413-/-Leu- in Aalpha-chain of fibrinogen =
Synonyms
3-203-fibrolase[3-serine], AfeE, Agkistrodon contortrix contortrix metalloproteinase, ALF, Alfimeprase, brevilysin L6, brevithrombolase, broad bean-fibrinolytic enzyme, CFR15-protease, fibrinolytic enzyme, fibrinolytic protease, Fibrinolytic proteinase, FIIa, neuwiedase, Non-hemorrhagic fibrinolytic metalloproteinase, plasmin, Proteinase, Agkistrodon contortrix contortrix venom metallo-, snake venom fibrinolytic enzyme, starase, UFEIII, VlF, wulfase
ECTree
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Reference on EC 3.4.24.72 - fibrolase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Guan, A.L.; Retzios, A.D.; Henderson, G.N.; Markland, F.S.
Purification and characterization of a fibrinolytic enzyme from venom of the southern copperhead snake (Agkistrodon contortrix contortrix)
Arch. Biochem. Biophys.
289
197-207
1991
Agkistrodon contortrix contortrix
Retzios, A.D.; Markland, F.S.
A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems
Thromb. Res.
52
541-552
1988
Agkistrodon contortrix contortrix
Randolph, A.; Chamberlain, S.H.; Chu, H.L.C.; Retzios, A.D.; Markland, F.S.; Masiarz, F.R.
Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix contortrix venom
Protein Sci.
1
590-600
1992
Agkistrodon contortrix contortrix
Loayza, S.L.; Trikha, M.; Markland, F.S.; Riquelme, P.; Kuo, J.
Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities
J. Chromatogr.
662
227-243
1994
Agkistrodon contortrix contortrix
Retzios, A.D.; Markland, F.S.
Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basiliscus basiliscus: cleavage site specificity towards the alpha-chain of fibrin
Thromb. Res.
74
355-367
1994
Agkistrodon contortrix contortrix
Manning, M.C.
Sequence analysis of fibrolase, a fibrinolytic metalloproteinase from Agkistrodon contortrix contortrix
Toxicon
33
1189-1200
1995
Agkistrodon contortrix contortrix
Trikha, M.; Schmitmeier, S.; Markland, F.S.
Purification and characterization of fibrolase isoforms from venom of individual southern copperhead (Agkistrodon contortrix Contortrix) snakes
Toxicon
32
1521-1531
1994
Agkistrodon contortrix contortrix
Patton, L.M.; Pretzer, D.; Schulteis, B.S.; Saggart, B.S.; Tennant, K.D.; Ahmed, N.K.
Activity assays for characterizing the thrombolytic protein fibrolase
J. Biochem. Biophys. Methods
27
11-23
1993
Agkistrodon contortrix contortrix
Markland, F.S.; Morris, S.; Deschamps, J.R.; Ward, K.B.
Resolution of isoforms of natural and recombinant fibrinolytic snake venom enzyme using high performance capillary electrophoresis
J. Liq. Chromatogr.
16
2189-2201
1993
Agkistrodon contortrix contortrix
-
Pretzer, D.; Schulteis, B.; Vander Velde, D.G.; Smith, C.D.; Mitchell, J.W.; Manning, M.C.
Effect of zinc binding on the structure and stability of fibrolase, a fibrinolytic protein from snake venom
Pharm. Res.
9
870-877
1992
Agkistrodon contortrix contortrix
Pretzer, D.; Schulteis, B.S.; Smith, C.D.; Vander Velde, D.G.; Mitchell, J.W.; Manning, M.C.
Stability of the thrombolytic protein fibrolase: effect of temperature and pH on activity and conformation
Pharm. Res.
8
1103-1112
1991
Agkistrodon contortrix contortrix
Chen, H.M.; Guan, A.L.; Markland, F.S.
Immunological properties of the fibrinolytic enzyme (fibrolase) from southern copperhead (Agkistrodon contortrix contortrix) venom and its purification by immunoaffinity chromatography
Toxicon
29
683-694
1991
Agkistrodon contortrix contortrix
Guan, A.L.; Markland, F.S.
Isoelectric focusing in immobilized pH gradients of a snake venom fibrinolytic enzyme
J. Biochem. Biophys. Methods
16
215-226
1988
Agkistrodon contortrix contortrix
Bolger, M.B.; Swenson, S.; Markland, F.S., Jr.
Three-dimensional structure of fibrolase, the fibrinolytic enzyme from southern copperhead venom, modeled from the X-ray structure of adamalysin II and atrolysin C
AAPS Pharmsci.
3
E16
2001
Agkistrodon contortrix contortrix (P28891), Agkistrodon contortrix contortrix
Swenson, S.; Toombs, C.F.; Pena, L.; Johansson, J.; Markland, F.S.
alpha-Fibrinogenases
Curr. Drug Targets Cardiovasc. Haematol. Disord.
4
417-435
2004
Agkistrodon contortrix
Swenson, S.; Markland, F.S.; Toombs, C.
Fibrolase
Handbook of Proteolytic Enzymes (Barrett,A. J. ;Rawlings,N. D. ,Woessner)
1
640-643
2004
Agkistrodon contortrix
-
Swenson, S.; Markland, F.S.
Snake venom fibrin(ogen)olytic enzymes
Toxicon
45
1021-1039
2005
Agkistrodon contortrix, Bothrops neuwiedi, Gloydius halys
Shi, J.; Zhang, S.T.; Zhang, X.J.; Xu, H.; Guo, A.G.
Expression, purification, and activity identification of alfimeprase in Pichia pastoris
Protein Expr. Purif.
54
240-246
2007
Agkistrodon contortrix contortrix (P28891)
Zhang, S.T.; Shi, J.; Zhao, J.; Qi, Y.F.; Guo, A.G.
Expression of soluble and functional snake venom fibrinolytic enzyme fibrolase via the co-expression of DsbC in Escherichia coli
Protein Pept. Lett.
13
559-563
2006
Agkistrodon contortrix contortrix (P28891), Agkistrodon contortrix contortrix
Swenson, S.; Markland, F.S.
Fibrolase
Toxin Rev.
25
351-378
2006
Agkistrodon contortrix contortrix
-
Toombs, C.F.; Deitcher, S.R.
Nonclinical and clinical characterization of a novel acting thrombolytic: alfimeprase
Toxin Rev.
25
379-392
2006
Agkistrodon contortrix contortrix
-
No authors listed
Alfimeprase
Drugs R. D.
9
185-190
2008
Agkistrodon contortrix contortrix
Verhamme, I.M.; Bock, P.E.
Rapid-reaction kinetic characterization of the pathway of streptokinase-plasmin catalytic complex formation
J. Biol. Chem.
283
26137-26147
2008
Homo sapiens
Lin, X.; Liang, X.; Tang, J.; Chen, J.; Qiu, P.; Yan, G.
The effect of the fibrinolytic enzyme FIIa from Agkistrodon acutus venom on acute pulmonary thromboembolism
Acta Pharmacol. Sin.
32
239-244
2011
Deinagkistrodon acutus
Fang, H.M.; Zhao, L.; Lu, P.; Chen, S.J.; Bao, Z.X.; Qin, Y.F.; Zhu, Z.Y.; Zhao, J.M.; Mai, J.; Zhang, S.T.
Modular design, expression and characterization of novel bifunctional mutants of fibrolase with combined platelet aggregation-inhibition and fibrinolytic activity
Protein J.
30
247-252
2011
Agkistrodon contortrix contortrix (P28891), Agkistrodon contortrix contortrix
Markland, F.S.; Swenson, S.
Fibrolase: trials and tribulations
Toxins
2
793-808
2010
Agkistrodon contortrix contortrix
Bajaj, B.; Sharma, N.; Singh, S.
Enhanced production of fibrinolytic protease from Bacillus cereus NS-2 using cotton seed cake as nitrogen source
Biocatal. Agricult. Biotechnol.
2
204-209
2013
Bacillus cereus, Bacillus cereus NS-2
-
Majumdar, S.; Sarmah, B.; Gogoi, D.; Banerjee, S.; Ghosh, S.; Banarjee, S.; Chattopadhyay, P.; Mukherjee, A.
Characterization, mechanism of anticoagulant action, and assessment of therapeutic potential of a fibrinolytic serine protease (Brevithrombolase) purified from Brevibacillus brevis strain FF02B
Biochimie
103
50-60
2014
Brevibacillus brevis, Brevibacillus brevis FF02B
Choi, J.; Sapkota, K.; Kim, S.; Kim, S.
Starase: A bi-functional fibrinolytic protease from hepatic caeca of Asterina pectinifera displays antithrombotic potential
Biochimie
105
45-57
2014
Patiria pectinifera
Bi, Q.; Han, B.; Liu, W.; Feng, Y.; Jiang, Z.
UFEIII, a fibrinolytic protease from the marine invertebrate, Urechis unicinctus
Biotechnol. Lett.
35
1115-1120
2013
Urechis unicinctus
Bajaj, B.; Singh, S.; Khullar, M.; Singh, K.; Bhardwaj, S.
Optimization of fibrinolytic protease production from Bacillus subtilis I-2 using agro-residues
Braz. Arch. Biol. Technol.
57
653-662
2014
Bacillus subtilis, Bacillus subtilis I-2
-
Silva, G.; Bezerra, R.; Teixeira, J.; Porto, T.; Lima-Filho, J.; Porto, A.
Fibrinolytic protease production by new Streptomyces sp. DPUA 1576 from Amazon lichens
Electron. J. Biotechnol.
18
16-19
2015
Streptomyces sp.
-
Bagchi, S.; Sondhia, S.; Agrawal, M.; Banerjee, S.
An angiotensin-converting enzyme-inhibitory metabolite with partial structure of microginin in a cyanobacterium Anabaena fertilissima CCC597, producing fibrinolytic protease
J. Appl. Phycol.
28
177-180
2016
Trichormus fertilissimus, Trichormus fertilissimus CCC597
-
Taneja, K.; Bajaj, B.; Kumar, S.; Dilbaghi, N.
Production, purification and characterization of fibrinolytic enzyme from Serratia sp. KG-2-1 using optimized media
3 Biotech
7
184
2017
Serratia sp. KG-2-1
Silva, G.; Bezerra, R.; Teixeira, J.; Silva, F.; Correia, J.; Porto, T.; Lima-Filho, J.; Porto, A.
Screening, production and biochemical characterization of a new fibrinolytic enzyme produced by Streptomyces sp. (Streptomycetaceae) isolated from Amazonian lichens
Acta Amaz.
46
301-310
2016
Streptomyces sp. DPUA 1576
-
Xiao, P.; Yao, S.; Liu, J.; Miao, Y.; Wang, Y.
Enhanced production of fibrinolytic enzyme from Bacillus amyloliquefaciens CGMCC 7380 using broad bean (Vicia faba L.) as substrate
Adv. J. Food Sci. Technol.
9
832-839
2015
Bacillus amyloliquefaciens, Bacillus amyloliquefaciens CGMCC 7380
-
Meshram, V.; Saxena, S.; Paul, K.; Gupta, M.; Kapoor, N.
Production, purification and characterisation of a potential fibrinolytic protease from endophytic Xylaria curta by solid substrate fermentation
Appl. Biochem. Biotechnol.
181
1496-1512
2017
Xylaria curta
Choi, J.; Lee, H.; Kim, S.
Purification and antithrombotic activity of wulfase, a fibrinolytic enzyme from the fruit bodies of the edible and medicinal mushroom Sparassis crispa Wulf. ex. Fr
Appl. Biochem. Microbiol.
52
608-614
2016
Sparassis crispa
-
Verma, P.; Chatterjee, S.; Keziah, M.S.; Devi, S.C.
Fibrinolytic protease from marine Streptomyces rubiginosus VITPSS1
Cardiovasc. Hematol. Agents Med. Chem.
16
44-55
2018
Streptomyces rubiginosus, Streptomyces rubiginosus VITPSS1
Yogesh, D.; Halami, P.
Evidence that multiple proteases of Bacillus subtilis can degrade fibrin and fibrinogen
Int. Food Res. J.
22
1662-1667
2015
Bacillus subtilis, Bacillus subtilis BR21
-
Sun, Z.; Liu, P.; Cheng, G.; Zhang, B.; Dong, W.; Su, X.; Huang, Y.; Cui, Z.; Kong, Y.
A fibrinolytic protease AfeE from Streptomyces sp. CC5, with potent thrombolytic activity in a mouse model
Int. J. Biol. Macromol.
85
346-354
2016
Streptomyces sp. CC5 (A0A0A7W604)
Nascimento, T.; Sales, A.; Porto, C.; Brandao, R.; de Campos-Takaki, G.; Teixeira, J.; Porto, T.; Porto, A.; Converti, A.
Purification of a fibrinolytic protease from Mucor subtilissimus UCP 1262 by aqueous two-phase systems (PEG/sulfate)
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
1025
16-24
2016
Mucor subtilissimus, Mucor subtilissimus UCP 1262
Khobragade, C.; Gophane, S.; Motwani, R.
Purification and characterization of extracellular protease from soil isolate Stenotrophomonas maltophilia as novel target for fibrinolysis
J. Microbiol. Biotechnol. Food Sci.
7
496-502
2018
Stenotrophomonas maltophilia, Stenotrophomonas maltophilia CNK-7R
-
Liu, X.; Kopparapu, N.; Zheng, H.; Katrolia, P.; Deng, Y.; Zheng, X.
Purification and characterization of a fibrinolytic enzyme from the food-grade fungus, Neurospora sitophila
J. Mol. Catal. B
134
98-104
2016
Neurospora sitophila
-
de Souza, F.; Sales, A.; Costa e Silva, P.; Bezerra, R.; de Medeiros e Silva, G.; de Araújo, J.; de Campos Takaki, G.; Porto, T.; Teixeira, J.; Porto, A.
Optimization of production, biochemical characterization and in vitro evaluation of the therapeutic potential of fibrinolytic enzymes from a new Bacillus amyloliquefaciens
Macromol. Res.
24
587-595
2016
Bacillus amyloliquefaciens, Bacillus amyloliquefaciens UFPEDA 485
-
D, D.; S, J.N.; S, M.K.; C, S.D.
Novel fibrinolytic protease producing Streptomyces radiopugnans VITSD8 from marine sponges
Mar. Drugs
17
164
2019
Streptomyces radiopugnans, Streptomyces radiopugnans VITSD8
Devaraj, Y.; Rajender, S.K.; Halami, P.M.
Purification and characterization of fibrinolytic protease from Bacillus amyloliquefaciens MCC2606 and analysis of fibrin degradation product by MS/MS
Prep. Biochem. Biotechnol.
48
172-180
2018
Bacillus amyloliquefaciens, Bacillus amyloliquefaciens MCC2606
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