3.4.24.72: fibrolase
This is an abbreviated version!
For detailed information about fibrolase, go to the full flat file.
Word Map on EC 3.4.24.72
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3.4.24.72
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plasmin
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thrombolytic
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copperhead
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fibrinogenolytic
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medicine
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nonhemorrhagic
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neuwiedi
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alteplase
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pharmacology
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drug development
- 3.4.24.72
- plasmin
-
thrombolytic
- copperhead
-
fibrinogenolytic
- medicine
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nonhemorrhagic
- neuwiedi
- alteplase
- pharmacology
- drug development
Reaction
Hydrolysis of -Ala14-/-Leu- in insulin B chain and -Lys413-/-Leu- in Aalpha-chain of fibrinogen =
Synonyms
3-203-fibrolase[3-serine], AfeE, Agkistrodon contortrix contortrix metalloproteinase, ALF, Alfimeprase, brevilysin L6, brevithrombolase, broad bean-fibrinolytic enzyme, CFR15-protease, fibrinolytic enzyme, fibrinolytic protease, Fibrinolytic proteinase, FIIa, neuwiedase, Non-hemorrhagic fibrinolytic metalloproteinase, plasmin, Proteinase, Agkistrodon contortrix contortrix venom metallo-, snake venom fibrinolytic enzyme, starase, UFEIII, VlF, wulfase
ECTree
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Metals Ions
Metals Ions on EC 3.4.24.72 - fibrolase
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Ca2+
Cu2+
Fe2+
K+
Mg2+
Mn2+
Na+
Zinc
Zn2+
additional information
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the activity of the enzyme is enhanced to 111.21% in the presence of 10 mM Mn2+
Na+
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the activity of protease is slightly enhanced (to 106%) by the presence of Na+ ions
Zinc
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effect of zinc binding on the structure and stability of fibrolase
Zn2+
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1 mol per mol of enzyme, fibrolase is a zinc metalloprotease with the zinc binding motif HEXXHXXGXXH
Zn2+
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a zinc metalloproteinase containing one mole of zinc
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the enzyme activity is not influenced by Mn2+, Cu2+, Ca2+, Mg2+, Co2+, Zn2+, and Fe2+