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3.4.24.70: oligopeptidase A

This is an abbreviated version!
For detailed information about oligopeptidase A, go to the full flat file.

Word Map on EC 3.4.24.70

Reaction

hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but additional information distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-/-Gly-Pro-Ala is cleaved, but not Z-(Gly)5 =

Synonyms

68000-M Signalpeptide hydrolase, More, oligopeptidase A, OpdA, prlC, TOP, Top1, Top2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.70 oligopeptidase A

KM Value

KM Value on EC 3.4.24.70 - oligopeptidase A

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0008
Abz-GASPFRQ-EDDnp
-
pH 7.4, 37°C, recombinant wild-type enzyme
0.0042
Abz-GDSPFRQ-EDDnp
-
pH 7.4, 37°C, recombinant wild-type enzyme
0.0018
Abz-GESPFRQ-EDDnp
-
pH 7.4, 37°C, recombinant wild-type enzyme
0.0007
Abz-GFSPFRQ-EDDnp
-
pH 7.4, 37°C, recombinant wild-type enzyme
0.0011
Abz-GGSPFRQ-EDDnp
-
pH 7.4, 37°C, recombinant wild-type enzyme
0.0004
Abz-GHSPFRQ-EDDnp
-
pH 7.4, 37°C, recombinant wild-type enzyme
0.0004
Abz-GKSPFRQ-EDDnp
-
pH 7.4, 37°C, recombinant wild-type enzyme
0.0018
Abz-GLSPFRQ-EDDnp
-
pH 7.4, 37°C, recombinant wild-type enzyme
0.0018
Abz-GNSPFRQ-EDDnp
-
pH 7.4, 37°C, recombinant wild-type enzyme
0.0007
Abz-GPSPFRQ-EDDnp
-
pH 7.4, 37°C, recombinant wild-type enzyme
0.0022
Abz-GQSPFRQ-EDDnp
-
pH 7.4, 37°C, recombinant wild-type enzyme
0.0002
Abz-GRSPFRQ-EDDnp
-
pH 7.4, 37°C, recombinant wild-type enzyme
0.0005
Abz-GSSPFRQ-EDDnp
-
pH 7.4, 37°C, recombinant wild-type enzyme
0.0007
Abz-GYSPFRQ-EDDnp
-
pH 7.4, 37°C, recombinant wild-type enzyme
additional information
additional information
-
kinetics of wild-type and mutant enzymes, overview
-