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3.4.24.70: oligopeptidase A

This is an abbreviated version!
For detailed information about oligopeptidase A, go to the full flat file.

Word Map on EC 3.4.24.70

Reaction

hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but additional information distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-/-Gly-Pro-Ala is cleaved, but not Z-(Gly)5 =

Synonyms

68000-M Signalpeptide hydrolase, More, oligopeptidase A, OpdA, prlC, TOP, Top1, Top2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.70 oligopeptidase A

Inhibitors

Inhibitors on EC 3.4.24.70 - oligopeptidase A

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
totally inhibits at 4 mM
Ca2+
about 75% inhibition at 1 mM
Fe3+
about 90% inhibition at 1 mM
JA-2
-
totally inhibits at 0.003 mM
Mg2+
about 75% inhibition at 1 mM
Na+
about 90% inhibition at 1 mM
Na-EDTA
50% inhibition at 10 mM
phenylmethylsulfonyl fluoride
PMSF, 80% inhibition at 1 mM
Pro-Ile
-
partly inhibits
salicylate
interacts with the isozyme and inhibits its peptidase activity to various degrees both in vitro and in plant extracts; interacts with the isozyme and inhibits its peptidase activity to various degrees both in vitro and in plant extracts. Specific isozyme TOP2–salicylate interaction may be dependent on plant-specific modifications of isozyme TOP2
salicylic acid
inhibits the peptidase activity of isozyme TOP1 and to a lesser extent isozyme TOP2; inhibits the peptidase activity of isozyme TOP1 and to a lesser extent isozyme TOP2
trans-epoxysuccinyl L-leucylamido-(4-guanidino)butane
E-64, 25% inhibition at 0.01 mM
additional information
-