3.4.24.65: macrophage elastase
This is an abbreviated version!
For detailed information about macrophage elastase, go to the full flat file.
Word Map on EC 3.4.24.65
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3.4.24.65
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metalloproteinases
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mmp-9
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pulmonary
-
emphysema
-
collagen
-
alveolar
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elastin
-
fibrosis
-
smoke
-
airway
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timp-1
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cigarette
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lavage
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bronchoalveolar
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endothelial
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metastasis
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aortic
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tnf
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artery
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chemokine
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monocyte
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smoking
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plaque
-
aneurysm
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angiogenesis
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atherosclerotic
-
zymography
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smoke-induced
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elastolytic
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proteinases
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plasminogen
-
asthma
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rupture
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angiostatin
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bal
-
instil
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urokinase-type
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matrilysin
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airspace
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mt1-mmp
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cs-induced
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elastases
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smoke-exposed
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emphysematous
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diagnostics
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drug development
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elastase-induced
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collagenase-3
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cs-exposed
-
airflow
-
medicine
-
pharmacology
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matrix-degrading
-
analysis
- 3.4.24.65
- metalloproteinases
- mmp-9
- pulmonary
- emphysema
- collagen
-
alveolar
- elastin
- fibrosis
-
smoke
- airway
- timp-1
-
cigarette
-
lavage
-
bronchoalveolar
- endothelial
- metastasis
- aortic
- tnf
- artery
- chemokine
- monocyte
-
smoking
- plaque
- aneurysm
- angiogenesis
- atherosclerotic
-
zymography
-
smoke-induced
-
elastolytic
- proteinases
- plasminogen
- asthma
-
rupture
- angiostatin
- bal
-
instil
-
urokinase-type
- matrilysin
-
airspace
- mt1-mmp
-
cs-induced
- elastases
-
smoke-exposed
-
emphysematous
- diagnostics
- drug development
-
elastase-induced
- collagenase-3
-
cs-exposed
-
airflow
- medicine
- pharmacology
-
matrix-degrading
- analysis
Reaction
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at -Ala14-/-Leu- and -Tyr16-/-Leu- in the B chain of insulin =
Synonyms
HME, hMMP-12, human macrophage elastase, Human macrophage metalloelastase, human metalloelastase, Macrophage elastase, macrophage matrix metalloproteinase, macrophage metalloelastase, macrophage-specific metalloelastase, matrix metalloproteinase 12, Matrix metalloproteinase-12, ME, Metalloelastase, MME, MMP-12, MMP12, More, mouse macrophage metalloelastase, rHME
ECTree
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KCat KM Value
KCat KM Value on EC 3.4.24.65 - macrophage elastase
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2
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
2
2-aminobenzoyl-ASVATELRAQ-2-(2,4-dinitrophenyl)aminoethylamide
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
2
2-aminobenzoyl-ASVATELRAQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
170
2-aminobenzoyl-ASVATELRAQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, full-length enzyme MMP-12, pH 7.5, 30°C
2
2-aminobenzoyl-EAAPSSVIAATE-2-(2,4-dinitrophenyl)aminoethylamide
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
2
2-aminobenzoyl-EAAPSSVIAATE-2-(2,4-dinitrophenyl)aminoethylamide
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
50
2-aminobenzoyl-EAAPSSVIAATE-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
4.7
2-aminobenzoyl-EPLALWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
69
2-aminobenzoyl-EPLALWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
620
2-aminobenzoyl-EPLALWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
5.9
2-aminobenzoyl-GAMFLEAIPMSIP-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
17
2-aminobenzoyl-GAMFLEAIPMSIP-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
110
2-aminobenzoyl-GAMFLEAIPMSIP-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
3.2
2-aminobenzoyl-GPLELEEAQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
3.6
2-aminobenzoyl-GPLELEEAQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
280
2-aminobenzoyl-GPLELEEAQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, full-length enzyme MMP-12, pH 7.5, 30°C
11
2-aminobenzoyl-GPLGLERAQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
38
2-aminobenzoyl-GPLGLERAQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
390
2-aminobenzoyl-GPLGLERAQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, full-length enzyme MMP-12, pH 7.5, 30°C
2
2-aminobenzoyl-GPLGLREAQ-2-(2,4-dinitrophenyl)aminoethylamide
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
24
2-aminobenzoyl-GPLGLREAQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
660
2-aminobenzoyl-GPLGLREAQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
7.4
2-aminobenzoyl-PLALWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
27
2-aminobenzoyl-PLALWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
190
2-aminobenzoyl-PLALWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
6.2
2-aminobenzoyl-PLGLEEA-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
10
2-aminobenzoyl-PLGLEEA-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
110
2-aminobenzoyl-PLGLEEA-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, full-length enzyme MMP-12, pH 7.5, 30°C
2
2-aminobenzoyl-RGLALWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
2
2-aminobenzoyl-RGLALWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
32
2-aminobenzoyl-RGLALWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, full-length enzyme MMP-12, pH 7.5, 30°C
-
2
2-aminobenzoyl-RNALAVERTAS-2-(2,4-dinitrophenyl)aminoethylamide
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
-
2
2-aminobenzoyl-RNALAVERTAS-2-(2,4-dinitrophenyl)aminoethylamide
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
-
140
2-aminobenzoyl-RNALAVERTAS-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
-
6.2
full-length enzyme MMP-12, pH 7.5, 30°C
13
2-aminobenzoyl-RPLALEESQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
61
2-aminobenzoyl-RPLALEESQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
1600
2-aminobenzoyl-RPLALEESQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
7.3
2-aminobenzoyl-RPLALRRSQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
71
2-aminobenzoyl-RPLALRRSQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
730
2-aminobenzoyl-RPLALRRSQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
7.4
2-aminobenzoyl-RPLALWEEQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
74
2-aminobenzoyl-RPLALWEEQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
420
2-aminobenzoyl-RPLALWEEQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
74
2-aminobenzoyl-RPLALWESQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
145
2-aminobenzoyl-RPLALWESQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
560
2-aminobenzoyl-RPLALWESQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
8.4
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
10
2-aminobenzoyl-RPLALWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
82
2-aminobenzoyl-RPLALWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
920
2-aminobenzoyl-RPLALWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2.3
full-length enzyme MMP-12, pH 7.5, 30°C
6
2-aminobenzoyl-RPLELWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
37
2-aminobenzoyl-RPLELWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
760
2-aminobenzoyl-RPLELWRSQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
8.5
2-aminobenzoyl-RPLGLEEA-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
64
2-aminobenzoyl-RPLGLEEA-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
720
2-aminobenzoyl-RPLGLEEA-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, full-length enzyme MMP-12, pH 7.5, 30°C
2.7
2-aminobenzoyl-RPLGLGAAQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
23
2-aminobenzoyl-RPLGLGAAQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
310
2-aminobenzoyl-RPLGLGAAQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, full-length enzyme MMP-12, pH 7.5, 30°C
2
2-aminobenzoyl-RPLGLGGAQ-2-(2,4-dinitrophenyl)aminoethylamide
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
9.3
2-aminobenzoyl-RPLGLGGAQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
59
2-aminobenzoyl-RPLGLGGAQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
2
below, recombinant catalytic domain of MMP-12, pH 7.5, 30°C
3.9
2-aminobenzoyl-RPLGLWGAQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
55
2-aminobenzoyl-RPLGLWGAQ-2-(2,4-dinitrophenyl)aminoethylamide
recombinant catalytic domain of MMP-12, pH 7.5, 30°C
700
2-aminobenzoyl-RPLGLWGAQ-2-(2,4-dinitrophenyl)aminoethylamide
full-length enzyme MMP-12, pH 7.5, 30°C
51.57
-
pH 7.5, 25°C, mutant D124Q/M156E/A182G
53.66
Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2
-
pH 7.5, 25°C, mutant D124Q/M156E/I180S
133.4
Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2
-
pH 7.5, 25°C, mutant D124Q/M156E/F185Y
159.7
Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2
-
pH 7.5, 25°C, mutant D124Q/M156E/T205K