3.4.24.62: magnolysin

This is an abbreviated version!
For detailed information about magnolysin, go to the full flat file.

Reaction

Hydrolysis of polypeptides with Arg or Lys in P1 and P2, e.g. to hydrolyse pro-oxytocin at -Lys-Arg-/-Ala-Val-. The specificity further depends on the organization of a beta-turn-alpha-helix of nine or additional information residues containing the paired basic amino acids near the centre =

Synonyms

Pro-oxytocin/neurophysin convertase, Proteinase, prooxyphysin, Bovine neurosecretory granule protease cleaving pro-oxytocin/neurophysin, Pro-oxytocin convertase, pro-ocytocin/neurophysin-converting enzyme, pro-ocytocin convertase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.62 magnolysin

Substrates Products

Substrates Products on EC 3.4.24.62 - magnolysin

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
peptide I + H2O
?
show the reaction diagram
-
-
-
-
?
Pro-oxytocin/neurophysin + H2O
?
show the reaction diagram
Pro-oxytocin/neurophysin(1-20) + H2O
Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20)
show the reaction diagram
[Ala10]-Pro-oxytocin/neurophysin(1-20) + H2O
?
show the reaction diagram
[Arg11,Lys12]-Pro-oxytocin/neurophysin(1-20) + H2O
?
show the reaction diagram
-
i.e. peptide VI, hydrolysis at the same rate as pro-oxytocin/neurophysin(1-20)
-
-
?
additional information
?
-