3.4.24.62: magnolysin
This is an abbreviated version!
For detailed information about magnolysin, go to the full flat file.
Reaction
Hydrolysis of polypeptides with Arg or Lys in P1 and P2, e.g. to hydrolyse pro-oxytocin at -Lys-Arg-/-Ala-Val-. The specificity further depends on the organization of a beta-turn-alpha-helix of nine or additional information residues containing the paired basic amino acids near the centre =
Synonyms
Bovine neurosecretory granule protease cleaving pro-oxytocin/neurophysin, pro-ocytocin convertase, pro-ocytocin/neurophysin-converting enzyme, Pro-oxytocin convertase, Pro-oxytocin/neurophysin convertase, Proteinase, prooxyphysin
ECTree
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Reference on EC 3.4.24.62 - magnolysin
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cohen, P.; Clamagirand, C.; Gluschankof, P.; Gomez, S.; Creminon, C.; Plevrakis, I.; Clavreul, C.; Fahy, C.; Boussetta, H.; et al.
Somatostatin-28 and pro-ocytocin/neurophysin convertases: basic pair selective endoproteases involved in pro-hormone processing in the rat brain cortex and bovine corpus luteum
Biochimie
70
17-23
1988
Bos taurus
Clamagirand, C.; Creminon, C.; Fahy, C.; Boussetta, H.; Cohen, P.
Partial purification and functional properties of an endoprotease from bovine neurosecretory granules cleaving proocytocin/neurophysin peptides at the basic amino acid doublet
Biochemistry
26
6018-6023
1987
Bos taurus
Clamagirand, C.; Camier, M.; Fahy, C.; Clavreul, C.; Creminon, C.; Cohen, P.
C-terminally extended ocytocin and pro-ocytocin: neurophysin peptide converting enzyme in bovine corpus luteum [published erratum appears in Biochem Biophys Res Commun 1987 May 14;144(3):1349]
Biochem. Biophys. Res. Commun.
143
789-796
1987
Bos taurus
Creminon, C.; Rholam, M.; Boussetta, H.; Marrakchi, N.; Cohen, P.
Synthetic peptide substrates as models to study a pro-ocytocin/neurophysin converting enzyme
J. Chromatogr.
440
439-448
1988
Bos taurus
Brakch, N.; Boussetta, H.; Rholam, M.; Cohen, P.
Processing endoprotease recognizes a structural feature at the cleavage site of peptide prohormones. The pro-ocytocin/neurophysin model
J. Biol. Chem.
264
15912-15916
1989
Bos taurus
Plevrakis, I.; Clamagirand, C.; Creminon, C.; Brakch, N.; Rholam, M.; Cohen, P.
Proocytocin/neurophysin convertase from bovine neurohypophysis and corpus luteum secretory granules: complete purification, structure-function relationships, and competitive inhibitor
Biochemistry
28
2705-2710
1989
Bos taurus
Guillou, M.D.; Camier, M.; Clamagirand, C.
Evidence for the presence of pro-oxytocin/neurophysin-converting enzyme in the human ovary
J. Endocrinol.
142
345-352
1994
Homo sapiens
Rholam, M.; Clamagirand, C.; Cohen, P.
Magnolysin
Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press
1
1039-1042
2004
Bos taurus, Homo sapiens
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