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3.4.24.62: magnolysin

This is an abbreviated version!
For detailed information about magnolysin, go to the full flat file.

Reaction

Hydrolysis of polypeptides with Arg or Lys in P1 and P2, e.g. to hydrolyse pro-oxytocin at -Lys-Arg-/-Ala-Val-. The specificity further depends on the organization of a beta-turn-alpha-helix of nine or additional information residues containing the paired basic amino acids near the centre =

Synonyms

Bovine neurosecretory granule protease cleaving pro-oxytocin/neurophysin, pro-ocytocin convertase, pro-ocytocin/neurophysin-converting enzyme, Pro-oxytocin convertase, Pro-oxytocin/neurophysin convertase, Proteinase, prooxyphysin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.62 magnolysin

Inhibitors

Inhibitors on EC 3.4.24.62 - magnolysin

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ca2+
-
weak, 1 mM, peptide I as substrate
Cd2+
-
weak, 0.1 mM, peptide I as substrate
Cys-Lys-Gly-Gly-Lys-Arg-Ala-Val-Lys-Cys
-
-
D-Arg12 derivate of pro-oxytocin/neurophysin (1-20)
-
Divalent cation chelators
-
-
-
Leu-Gly-Gly-Lys-Arg-Ala-Val-Lys-Asp
-
-
p-(chloromercuri)-benzenesulfonic acid
p-chloromercuriphenylsulfonic acid
Zn2+
-
1 mM, peptide I as substrate
[D-Arg12]-Pro-oxytocin/neurophysin(1-20)
additional information
-