3.4.24.59: mitochondrial intermediate peptidase
This is an abbreviated version!
For detailed information about mitochondrial intermediate peptidase, go to the full flat file.
Word Map on EC 3.4.24.59
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3.4.24.59
-
mpp
-
presequence
-
oct1
-
mating-type
-
tetrapolarity
-
schizophyllum
-
homobasidiomycetes
-
heterothallic
- 3.4.24.59
- mpp
- presequence
- oct1
-
mating-type
-
tetrapolarity
-
schizophyllum
- homobasidiomycetes
-
heterothallic
Reaction
release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion =
Synonyms
At1g09300, hMIP, Icp55, MIP, MIP1, MIPEP, mitochondrial intermediate peptidase, OCT1, octapeptidyl aminopeptidase 1, Proteinase, mitochondrial intermediate precursor-processing
ECTree
3.4.24.59 mitochondrial intermediate peptidaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.4.24.59 - mitochondrial intermediate peptidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
51 kDa subunit of complex I + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
ABC transporter of the mitochondrion 1 + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
alanine aminotransferase + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
alanine aminotransferase 2 + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
alanine:glyoxylate aminotransferase 3 + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
aldehyde dehydrogenase 2B + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
aldehyde dehydrogenase 6B + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
alpha/beta-hydrolases superfamily protein + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
ATP-dependent caseinolytic protease + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
cofactor of nitrate reductase + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
copper ion binding protein + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
dihydrolipoamide acetyltransferase + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
dihydrolipoamide succinyltransferase + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
electron transfer flavoprotein alpha + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
FAD-linked oxidases family protein + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
glutamate tRNA synthetase + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
iron-sulfur cluster biosynthesis family protein + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
isopentenyl diphosphate isomerase + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
lactate/malate dehydrogenase family protein + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
lipoamide dehydrogenase 2 + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
methylenetetrahydrofolate reductase family protein + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
mitochondrial acyl carrier protein 1 + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
mitochondrial acyl carrier protein 2 + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
mitochondrial acyl carrier protein 3 + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
mitochondrial glycoprotein family protein + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
mitochondrial RNA helicase 2 + H2O
?
W6HYK5
substrate of isoform OCT1
-
-
?
monodehydroascorbate reductase 6 + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
NAD(P)-binding Rossmann-fold superfamily protein + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
NADH-ubiquinone oxidoreductase-related protein + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
NADPH-dependent thioredoxin reductase B + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
Notch receptor + H2O
?
-
Notch is proteolysed at the S5 site which is 8 amino acids downstream of the S3 site, generating a DELTA NICD (Notch intracellular domain) fragment
-
-
?
nuclear-encoded CLP protease P7 + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
O-acetylserine (thiol) lyase isoform C + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
octapeptide from the mitochondrial processing peptidase-generated N-terminus in the substrate proteins + H2O
?
-
-
-
-
?
pentatricopeptide repeat protein + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
phenylalanyl-tRNA synthetase + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
Precursor proteins that have already been processed by mitochondrial processing peptidase + H2O
?
primosome PriB/single-strand DNA-binding protein + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
Proteins with the octapeptide Phe-Xaa-Xaa-Ser-Xaa-Xaa-Xaa-Xaa at the amino termini + H2O
Protein + Phe-Xaa-Xaa-Ser-Xaa-Xaa-Xaa-Xaa
-
amino-terminal octapeptide can be cleaved only within the structural context of twice-cleaved precursors
-
-
?
radical SAM superfamily protein + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
Rieske iron sulfur protein from complex III + H2O
?
W6HYK5
substrate of isoform OCT1
-
-
?
rubredoxin-like superfamily protein + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
S-adenosyl-L-methionine-dependent methyltransferase + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
serine hydroxymethyltransferase + H2O
?
maturation of serine hydroxymethyltransferase by ICP55 involves breaking an aminoterminal diserine and appears to destabilize rather than stabilize this enzyme
-
-
?
succinate dehydrogenase 1-1 + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
succinyl-CoA ligase alpha subunit + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
transketolase family protein + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
translation elongation factor Ts + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
UDP-3-O-acyl N-acetylglycosamine deacetylase + H2O
?
W6HYK5
substrate of isoform ICP55
-
-
?
Ygr031w/Imo32 + H2O
?
-
Ygr031w/Imo32 encodes an Oct1 substrate protein with an unusual sequence motif
-
-
?
cytochrome c oxidase 4 precursor protein + H2O
mature cytochrome c oxidase + propeptide
-
enzyme inhibition leads to prevention of the normal processing of the precursor of cytochrome c oxidase, i.e. COX, subunit 4 and induced COX degradation, overview
-
-
?
cytochrome c oxidase 4 precursor protein + H2O
mature cytochrome c oxidase + propeptide
-
identification of the MIP recognition site, overview
-
-
?
Mitochondrial intermediate proteins + H2O
?
-
with the amino-terminal octapeptide Phe/Ile/Leu-Xaa-Xaa-Ser/Thr/Gly-Xaa-Xaa-Xaa-Xaa
-
-
?
Mitochondrial intermediate proteins + H2O
?
-
respiratory components, including subunits of electron transport chain and tricarboxylic acid cycle enzymes, and components of the mitochondrial genetic machinery, including ribosomal proteins, translation factors, and proteins required for mitochondrial DNA metabolism
-
-
?
Mitochondrial intermediate proteins + H2O
?
-
with the amino-terminal octapeptide Phe/Ile/Leu-Xaa-Xaa-Ser/Thr/Gly-Xaa-Xaa-Xaa-Xaa
-
-
?
Precursor proteins that have already been processed by mitochondrial processing peptidase + H2O
?
-
required step for a subgroup of nuclear-encoded mitochondrial precursors
-
-
?
Precursor proteins that have already been processed by mitochondrial processing peptidase + H2O
?
-
-
-
-
?
Precursor proteins that have already been processed by mitochondrial processing peptidase + H2O
?
-
a new component of the yeast mitochondrial import machinery
-
-
?
additional information
?
-
W6HYK5
isoform ICP55 has a consensus cleavage motif of RX(F/Y/I/L)*(S/A)(S/T)
-
-
?
additional information
?
-
-
isoform ICP55 has a consensus cleavage motif of RX(F/Y/I/L)*(S/A)(S/T)
-
-
?
additional information
?
-
-
enzyme is involved in two-step processing of mitochondrial protein precursors
-
-
?
additional information
?
-
-
enzyme is involved in two-step processing of mitochondrial protein precursors
-
-
?
