3.4.24.59: mitochondrial intermediate peptidase

This is an abbreviated version!
For detailed information about mitochondrial intermediate peptidase, go to the full flat file.

Reaction

release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion =

Synonyms

At1g09300, hMIP, Icp55, MIP, MIP1, MIPEP, mitochondrial intermediate peptidase, OCT1, octapeptidyl aminopeptidase 1, Proteinase, mitochondrial intermediate precursor-processing

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.59 mitochondrial intermediate peptidase

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Results	in table
1	Activating Compound
3275	AA Sequence
1	Application
1	CAS Registry Number
9	Cloned(Commentary)
11	Disease/ Diagnostics
5	General Information
33	Inhibitors
15	kcat/KM [mM/s]
3	Ki Value [mM]
15	KM Value [mM]
14	Localization
11	Metals/Ions
10	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
21	Organism
3	pH Optimum
1	pH Range
2	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
21	Reference
11	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Storage Stability
103	Substrates and Products (Substrate)
8	Subunits
26	Synonyms
2	Temperature Optimum [°C]
14	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.24.59 - mitochondrial intermediate peptidase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

cytochrome c oxidase 4 precursor protein + H2O

mature cytochrome c oxidase + propeptide

Homo sapiens

-

enzyme inhibition leads to prevention of the normal processing of the precursor of cytochrome c oxidase, i.e. COX, subunit 4 and induced COX degradation, overview

683116

-

-

?

frataxin + H2O

?

Rattus norvegicus

-

-

733399

-

-

?

Mitochondrial intermediate proteins + H2O

?

2 entries

Precursor proteins that have already been processed by mitochondrial processing peptidase + H2O

?

3 entries

serine hydroxymethyltransferase + H2O

?

Arabidopsis thaliana

F4HZG9

maturation of serine hydroxymethyltransferase by ICP55 involves breaking an aminoterminal diserine and appears to destabilize rather than stabilize this enzyme

755046

-

-

?

Mitochondrial intermediate proteins + H2O

?

Arabidopsis thaliana

W6HYK5

-

734387

-

-

?

Mitochondrial intermediate proteins + H2O

?

Homo sapiens

-

-

753580

-

-

?

Precursor proteins that have already been processed by mitochondrial processing peptidase + H2O

?

Rattus norvegicus

-

required step for a subgroup of nuclear-encoded mitochondrial precursors

31354

-

-

?

Precursor proteins that have already been processed by mitochondrial processing peptidase + H2O

?

Saccharomyces cerevisiae

-

-

31358

-

-

?

Precursor proteins that have already been processed by mitochondrial processing peptidase + H2O

?

Saccharomyces cerevisiae

-

a new component of the yeast mitochondrial import machinery

31355

-

-

?