3.4.24.54: mucrolysin
This is an abbreviated version!
For detailed information about mucrolysin, go to the full flat file.
Word Map on EC 3.4.24.54
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3.4.24.54
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metallopeptidase
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insulysin
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insulin-degrading
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venom
-
snake
-
amyloidogenic
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nardilysin
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metalloprotease
-
convertase
-
beta-peptide
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mucrosquamatus
-
medicine
- 3.4.24.54
- metallopeptidase
- insulysin
-
insulin-degrading
- venom
-
snake
-
amyloidogenic
- nardilysin
- metalloprotease
-
convertase
-
beta-peptide
- mucrosquamatus
- medicine
Reaction
Cleavage of Ser9-/-His, His10-/-Leu, Ala14-/-Leu, Leu15-/-Tyr and Tyr16-/-Leu bonds in insulin B chain =
Synonyms
Mucrotoxin A, Trimeresurus metalloendopeptidase A
ECTree
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Substrates Products
Substrates Products on EC 3.4.24.54 - mucrolysin
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REACTION DIAGRAM
Ala-Leu + H2O
Alanine + leucine
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less effective than Gly-Pro, Leu-Gly or Gly-Leu
-
?
Fibrinogen + H2O
Hydrolyzed fibrinogen
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hydrolyzes first the Aalpha and then the Bbeta chain
-
?
Gly-Gly + H2O
Glycine + glycine
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less effective than Gly-Pro, Leu-Gly or Gly-Leu
-
?
Gly-Met + H2O
glycine + L-methionine
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less effective than Gly-Pro, Leu-Gly or Gly-Leu
-
-
?
Gly-Tyr + H2O
Glycine + tyrosine
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less effective than Gly-Pro, Leu-Gly or Gly-Leu
-
?
His-Leu + H2O
Histidine + leucine
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less effective than Gly-Pro, Leu-Gly or Gly-Leu
-
?
insulin B chain + H2O
?
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hydrolyzes Aalpha chain first and then the Bbeta chain
-
-
?
Leu-Tyr + H2O
Leucine + tyrosine
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less effective than Gly-Pro, Leu-Gly or Gly-Leu
-
?
Oxidized insulin B-chain + H2O
Hydrolyzed insulin B-chain
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cleavage at Ser9-His10, His10-Leu11, Ala14-Leu15, Leu15-Tyr16 and Tyr16-Leu17
-
?
Tyr-Leu + H2O
Tyrosine + leucine
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less effective than Gly-Pro, Leu-Gly or Gly-Leu
-
?
?
-
-
no substrate: casein, exhibits lethal and hemorrhagic activity
-
-
?
additional information
?
-
-
no substrate: casein, exhibits lethal and hemorrhagic activity
-
-
?
additional information
?
-
-
produces hemorrhage in heart and stomach
-
-
?