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3.4.24.49: bothropasin

This is an abbreviated version!
For detailed information about bothropasin, go to the full flat file.

Word Map on EC 3.4.24.49

Reaction

Cleavage of His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Tyr16-/-Leu and Phe24-/-Phe in insulin B chain =

Synonyms

Bothrops jararaca snake venom metalloproteinase, HF3, Proteinase, Bothrops jararaca venom metallo-, snake venom metalloproteinase, SVMP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.49 bothropasin

Reference

Reference on EC 3.4.24.49 - bothropasin

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mandelbaum, F.R.; Reichel, A.P.; Assakura, M.T.
Isolation and characterization of a proteolytic enzyme from the venom of the snake Bothrops jararaca (Jararaca)
Toxicon
20
955-972
1982
Bothrops jararaca
Manually annotated by BRENDA team
Mandelbaum, F.R.; Assakura, M.T.; Reichl, A.P.; Serrano, S.M.
Bothropasin
Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press
1
658-659
2004
Bothrops jararaca
-
Manually annotated by BRENDA team
Carneiro, S.M.; Zablith, M.B.; Kerchove, C.M.; Moura-da-Silva, A.M.; Quissell, D.O.; Markus, R.P.; Yamanouye, N.
Venom production in long-term primary culture of secretory cells of the Bothrops jararaca venom gland
Toxicon
47
87-94
2006
Bothrops jararaca
Manually annotated by BRENDA team
Muniz, J.R.; Ambrosio, A.L.; Selistre-de-Araujo, H.S.; Cominetti, M.R.; Moura-da-Silva, A.M.; Oliva, G.; Garratt, R.C.; Souza, D.H.
The three-dimensional structure of bothropasin, the main hemorrhagic factor from Bothrops jararaca venom: insights for a new classification of snake venom metalloprotease subgroups
Toxicon
52
807-816
2008
Bothrops jararaca (O93523), Bothrops jararaca
Manually annotated by BRENDA team
Oliveira, A.K.; Paes Leme, A.F.; Assakura, M.T.; Menezes, M.C.; Zelanis, A.; Tashima, A.K.; Lopes-Ferreira, M.; Lima, C.; Camargo, A.C.; Fox, J.W.; Serrano, S.M.
Simplified procedures for the isolation of HF3, bothropasin, disintegrin-like/cysteine-rich protein and a novel P-I metalloproteinase from Bothrops jararaca venom
Toxicon
53
797-801
2009
Bothrops jararaca (O93523), Bothrops jararaca
Manually annotated by BRENDA team
Oliveira, A.K.; Paes Leme, A.F.; Asega, A.F.; Camargo, A.C.; Fox, J.W.; Serrano, S.M.
New insights into the structural elements involved in the skin haemorrhage induced by snake venom metalloproteinases
Thromb. Haemost.
104
485-497
2010
Bothrops jararaca
Manually annotated by BRENDA team
Paes Leme, A.; Sherman, N.; Smalley, D.; Sizukusa, L.; Oliveira, A.; Menezes, M.; Fox, J.; Serrano, S.
Hemorrhagic activity of HF3, a snake venom metalloproteinase: Insights from the proteomic analysis of mouse skin and blood plasma
J. Proteome Res.
11
279-291
2012
Bothrops jararaca (Q98UF9), Bothrops jararaca
Manually annotated by BRENDA team
Srinivasa, V.; Sundaram, M.; Anusha, S.; Hemshekhar, M.; Nayaka, S.; Kemparaju, K.; Basapp, B.; Girish, K.; Rangappa, K.
Novel apigenin based small molecule that targets snake venom metalloproteases
PLoS ONE
9
e106364
2014
Echis carinatus (Q9PRP9), Echis carinatus
Manually annotated by BRENDA team
Silva, C.C.F.; Menezes, M.C.; Palomino, M.; Oliveira, A.K.; Iwai, L.K.; Faria, M.; Portaro, F.V.
Peptides derived from plasma proteins released by bothropasin, ametalloprotease present in the Bothrops jararaca venom
Toxicon
137
65-72
2017
Bothrops jararaca (O93523), Bothrops jararaca
Manually annotated by BRENDA team