3.4.24.46: adamalysin
This is an abbreviated version!
For detailed information about adamalysin, go to the full flat file.
Word Map on EC 3.4.24.46
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3.4.24.46
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metalloproteinases
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disintegrin
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snake
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metzincins
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electrotransfer
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adam15
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astacins
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matrixins
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alpha-secretase
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met-turn
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hexxhxxgxxh
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medicine
- 3.4.24.46
- metalloproteinases
-
disintegrin
-
snake
-
metzincins
-
electrotransfer
- adam15
- astacins
- matrixins
- alpha-secretase
-
met-turn
-
hexxhxxgxxh
- medicine
Reaction
Cleavage of Phe1-/-Val, His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Leu15-/-Tyr, and Tyr16-/-Leu of insulin B chain =
Synonyms
Adamalysin II, Crotalus adamanteus metalloendopeptidase, Crotalus adamanteus venom proteinase II, metargidin, Proteinase I and II, Proteinase, Crotalus adamanteus venom, II
ECTree
3.4.24.46 adamalysinAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.4.24.46 - adamalysin
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
human plasma alpha1-proteinase inhibitor + H2O
hydrolyzed and inactivated human plasma alpha1-proteinase inhibitor
Oxidized insulin B-chain + H2O
?
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cleavage at Phe1-Val2, His5-Leu6, His10-Leu11, Ala14-Leu15, Leu15-Tyr16 and Tyr16-Leu17
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?
Polyarginine + H2O
Hydrolyzed polyarginine
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chain length 6-12 amino acids, not arginine monomers
?
Polylysine + H2O
Hydrolyzed polylysine
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chain length 6-12 amino acids, not lysine monomers
?
Human antithrombin III + H2O
Hydrolyzed and inactivated antithrombin III
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in the presence of heparin non-inactivating cleavage in aminoterminal region at Glu37-Gln38 followed by inactivating cleavages in carboxyterminal region at Ala375-Ser376 and Ala378-Val379, in the absence of heparin inactivating cleavage in carboxyterminal region at Ser383-Ala384
first occuring fragment in the presence of heparin is a still active antithrombin of MW 56000, followed by inactive fragments of MW 50000 and MW 5000, in the absence of heparin only inactive fragments of MW 56000 and MW 5000 occur
?
Human antithrombin III + H2O
Hydrolyzed and inactivated antithrombin III
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MW 60000, at a molar ratio of antithrombin III:enzyme of 40:1, in the presence and absence of heparin
first occuring fragment in the presence of heparin is a still active antithrombin of MW 56000, followed by inactive fragments of MW 50000 and MW 5000, in the absence of heparin only inactive fragments of MW 56000 and MW 5000 occur
?
human plasma alpha1-proteinase inhibitor + H2O
hydrolyzed and inactivated human plasma alpha1-proteinase inhibitor
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no hydrolysis in the presence of alpha1-macroglobulin
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-
?
human plasma alpha1-proteinase inhibitor + H2O
hydrolyzed and inactivated human plasma alpha1-proteinase inhibitor
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MW 54000, native and heat-denatured, the latter is more extensively hydrolyzed
MW 50000 and MW 4000 fragments
?
additional information
?
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no hydrolysis of benzoyl-L-Arg ethyl ester, benzoyl-L-Tyr ethyl ester
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?
additional information
?
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snake venom zincendopeptidase, hydrolyzes basement membrane proteins involved in the adhesion among capillary endothelial cells, inducing extensive haemorrhages in the bitten preys
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?
additional information
?
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disintegrin domain of enzyme acts as inhibitor of angiogenesis, tumor growth, and metastasis
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?
