3.4.24.46: adamalysin
This is an abbreviated version!
For detailed information about adamalysin, go to the full flat file.
Word Map on EC 3.4.24.46
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3.4.24.46
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metalloproteinases
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disintegrin
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snake
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metzincins
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electrotransfer
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adam15
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astacins
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matrixins
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alpha-secretase
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met-turn
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hexxhxxgxxh
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medicine
- 3.4.24.46
- metalloproteinases
-
disintegrin
-
snake
-
metzincins
-
electrotransfer
- adam15
- astacins
- matrixins
- alpha-secretase
-
met-turn
-
hexxhxxgxxh
- medicine
Reaction
Cleavage of Phe1-/-Val, His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Leu15-/-Tyr, and Tyr16-/-Leu of insulin B chain =
Synonyms
Adamalysin II, Crotalus adamanteus metalloendopeptidase, Crotalus adamanteus venom proteinase II, metargidin, Proteinase I and II, Proteinase, Crotalus adamanteus venom, II
ECTree
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Natural Substrates Products on EC 3.4.24.46 - adamalysin
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REACTION DIAGRAM
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snake venom zincendopeptidase, hydrolyzes basement membrane proteins involved in the adhesion among capillary endothelial cells, inducing extensive haemorrhages in the bitten preys
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additional information
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disintegrin domain of enzyme acts as inhibitor of angiogenesis, tumor growth, and metastasis
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