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3.4.24.46: adamalysin

This is an abbreviated version!
For detailed information about adamalysin, go to the full flat file.

Word Map on EC 3.4.24.46

Reaction

Cleavage of Phe1-/-Val, His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Leu15-/-Tyr, and Tyr16-/-Leu of insulin B chain =

Synonyms

Adamalysin II, Crotalus adamanteus metalloendopeptidase, Crotalus adamanteus venom proteinase II, metargidin, Proteinase I and II, Proteinase, Crotalus adamanteus venom, II

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.46 adamalysin

Inhibitors

Inhibitors on EC 3.4.24.46 - adamalysin

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
2 mM Zn2+ protects at 2 mM 2-mercaptoethanol, 2 mM Zn2+ partially protects at 10-50 mM 2-mercaptoethanol, 2 mM Ca2+ partially protects at 2-10 mM 2-mercaptoethanol, no protection at 50 mM 2-mercaptoethanol
Acetyl-Trp-Cys-Gly-Pro-NH2
-
-
alpha1-Macroglobulin
-
mechanism
-
cysteine
Fur-Leu-Trp-OH
-
-
Lys-Pro-Arg-Cys-Gly-Val-NH2
-
-
Lys-Thr-Phe-Thr-Ser-Cys
-
-
N-(furan-2-yl)carbonyl-L-leucyl-D-phosphotryptophan
-
-
N-(furan-2-yl)carbonyl-L-leucyl-L-phosphotryptophan
-
-
N-(furan-2-yl)carbonyl-Leu-Trp(P)-(OH)2
-
-
Pro-Lys-Met-Cys-Gly-Val-NH2
-
strong
Pro-Lys-Met-D-Cys-Gly-Val-NH2
-
less effective than Pro-Lys-Met-Cys-Gly-Val-NH2
Pro-Lys-Met-Ser-Gly-Val-NH2
-
weak
PyroGlu-Asn-Trp
-
naturally found endogenous venom tripeptide inhibitor
additional information
-
no inhibition by diisopropyl fluorophosphate
-