3.4.24.46: adamalysin

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For detailed information about adamalysin, go to the full flat file.

Reaction

Cleavage of Phe1-/-Val, His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Leu15-/-Tyr, and Tyr16-/-Leu of insulin B chain =

Synonyms

Adamalysin II, Crotalus adamanteus metalloendopeptidase, Crotalus adamanteus venom proteinase II, metargidin, Proteinase I and II, Proteinase, Crotalus adamanteus venom, II

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.46 adamalysin

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Results	in table
2	Activating Compound
2	AA Sequence
1	Application
1	CAS Registry Number
8	Crystallization (Commentary)
46	Disease/ Diagnostics
20	Inhibitors
11	Metals/Ions
8	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
11	Organism
4	PDB ID
1	pH Optimum
1	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
11	Reference
7	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
12	Substrates and Products (Substrate)
2	Subunits
9	Synonyms
2	Temperature Optimum [°C]

Engineering

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Engineering on EC 3.4.24.46 - adamalysin

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

additional information

Homo sapiens

-

recombinant disintegrin domain of enzyme, shows inhibitory activities on endothelial cell proliferation and adhesion on the integrin substrates fibronectin, vitronectin, and fibrinogen.The domain totally abrogates endothelial cell migration and blocks most capillary formation in a three-dimensional fibrin gel. Athymic mice bearing electrotransferred domain exhibit strong inhibition of tumor angiogenesis

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