3.4.24.46: adamalysin

This is an abbreviated version!
For detailed information about adamalysin, go to the full flat file.

Word Map on EC 3.4.24.46

3.4.24.46

metalloproteinases

disintegrin

snake

metzincins

electrotransfer

adam15

astacins

matrixins

alpha-secretase

met-turn

hexxhxxgxxh

medicine

Reaction

Cleavage of Phe1-/-Val, His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Leu15-/-Tyr, and Tyr16-/-Leu of insulin B chain =

Synonyms

Adamalysin II, Crotalus adamanteus metalloendopeptidase, Crotalus adamanteus venom proteinase II, metargidin, Proteinase I and II, Proteinase, Crotalus adamanteus venom, II

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.46 adamalysin

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Results	in table
2	Activating Compound
2	AA Sequence
1	Application
1	CAS Registry Number
8	Crystallization (Commentary)
46	Disease/ Diagnostics
20	Inhibitors
11	Metals/Ions
8	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
11	Organism
4	PDB ID
1	pH Optimum
1	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
11	Reference
7	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
12	Substrates and Products (Substrate)
2	Subunits
9	Synonyms
2	Temperature Optimum [°C]

Disease

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Disease on EC 3.4.24.46 - adamalysin

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Adenocarcinoma

Inhibitory antibodies against endopeptidase activity of human adamalysin 19.

11708814

Carcinoma

Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence.

8617717

Melanoma

Antiangiogenic Metargidin Peptide (AMEP) Gene Therapy in Disseminated Melanoma.

26072417

Biological Properties of Melanoma and Endothelial Cells after Plasmid AMEP Gene Electrotransfer Depend on Integrin Quantity on Cells.

23649038

Gene electrotransfer of plasmid AMEP, an integrin-targeted therapy, has antitumor and antiangiogenic action in murine B16 melanoma.

25781650

Gene Electrotransfer of Plasmid Antiangiogenic Metargidin Peptide (AMEP) in Disseminated Melanoma: Safety and Efficacy Results of a Phase I First-in-Man Study.

23980876

Neoplasms

ADAMs family members as amyloid precursor protein alpha-secretases.

14598310

Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins.

19718658

Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide.

12621058

MicroRNAs and the hallmarks of cancer.

17028596

P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells.

20064929

Regulation of tumor necrosis factor-alpha and tumor necrosis factor converting enzyme in human osteoarthritis.

10419777

Structures of adamalysin II with peptidic inhibitors. Implications for the design of tumor necrosis factor alpha convertase inhibitors.

9521103

The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor-alpha convertase.

9684866

Tumor angiogenesis and anti-angiogenic gene therapy for cancer.

29963134

Oligodendroglioma

Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity.

22406378

Osteoarthritis

Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage.

33381768

Regulation of tumor necrosis factor-alpha and tumor necrosis factor converting enzyme in human osteoarthritis.

10419777

Purpura, Thrombotic Thrombocytopenic

Complement activation in diseases presenting with thrombotic microangiopathy.

23743117