3.4.24.27: thermolysin
This is an abbreviated version!
For detailed information about thermolysin, go to the full flat file.
Word Map on EC 3.4.24.27
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3.4.24.27
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chymotrypsin
-
elastase
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metalloprotease
-
subtilisin
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staphylococcus
-
edman
-
pepsin
-
aureus
-
carboxypeptidase
-
endopeptidase
-
bromide
-
cyanogen
-
collagenase
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proteinases
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dipeptide
-
angiotensin
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pronase
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metalloproteinases
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alpha-chymotrypsin
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thermolytic
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hydrolysates
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metalloendopeptidase
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stearothermophilus
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endoproteinase
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phosphoramidon
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i-converting
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enkephalinase
-
rhodopsin
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2-macroglobulin
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3.4.24.11
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cell-binding
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alcalase
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ace-inhibitory
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hexxh
-
dispase
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aspartame
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thiorphan
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neprilysin
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s-carboxymethylated
-
half-cystine
-
astacin
-
synthesis
-
industry
-
nutrition
-
food industry
-
diagnostics
-
medicine
-
analysis
- 3.4.24.27
- chymotrypsin
- elastase
- metalloprotease
- subtilisin
- staphylococcus
-
edman
- pepsin
- aureus
- carboxypeptidase
- endopeptidase
- bromide
-
cyanogen
- collagenase
- proteinases
- dipeptide
- angiotensin
- pronase
- metalloproteinases
- alpha-chymotrypsin
-
thermolytic
- hydrolysates
- metalloendopeptidase
- stearothermophilus
-
endoproteinase
- phosphoramidon
-
i-converting
- enkephalinase
- rhodopsin
-
2-macroglobulin
-
3.4.24.11
-
cell-binding
- alcalase
-
ace-inhibitory
-
hexxh
-
dispase
- aspartame
- thiorphan
- neprilysin
-
s-carboxymethylated
-
half-cystine
- astacin
- synthesis
- industry
- nutrition
- food industry
- diagnostics
- medicine
- analysis
Reaction
preferential cleavage: -/-Leu > -/-Phe =
Synonyms
Bacillus thermoproteolyticus neutral proteinase, EC 3.4.24.4, hspA, LIC13322, Neutral metalloproteinase, NprM, protease type X, proteinase type X, Proteinase, Bacillus thermoproteolyticus neutral, protex 14L, Thermoase, thermoase PC10F, Thermoase Y10, thermolysin, thermolysin-like protease, Thermostable neutral proteinase, TL, TLN, TLP, TLP-ste
ECTree
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KI Value
KI Value on EC 3.4.24.27 - thermolysin
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0.000000064
1-beta-D-arabinofuranosyl-N4-lauroylcytosine
-
25°C, pH 7.5
0.0593
2-(4-methylphenyl)-3-(1,3-thiazol-2-yl) quinazolin-4(3H)-one
-
at pH 7.0 and 25°C
0.57
2-(acetyloxy)-3-chlorobenzoic acid
in 100 mM Tris/HCl, pH 7.5, 2 mM CaCl2, 4% (v/v) DMSO, at 25°C
0.315
2-ethyl-3-hydroxyquinazolin-4(3H)-one
in 100 mM Tris/HCl, pH 7.5, 2 mM CaCl2, 4% (v/v) DMSO, at 25°C
2.06
2-hydroxy-N-(4-methyl-2-nitrophenyl)-3-nitrobenzamide
-
25°C, pH 7.5
1.6
2-phenylpropionyl-L-phenylalanine
-
pH 8.6, temperature not specified in the publication
0.000015
2-phenylpropionyl-Leu-Trp
-
pH 7.2, temperature not specified in the publication
0.000243
3-(isopropylideneamino)-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-one
-
at pH 7.0 and 25°C
0.0183
3-([(1E)-[4-(dimethylamino) phenyl]methylene]amino)-2-methylquinazolin-4(3H)-one
-
at pH 7.0 and 25°C
0.042
3-([(1E)-[4-(dimethylamino) phenyl]methylene]amino)-2-phenylquinazolin-4(3H)-one
-
at pH 7.0 and 25°C
10100
3-amino-2-(4-chlorophenyl)quinazolin-4(3H)-one
-
at pH 7.0 and 25°C
3.12
3-amino-2-(4-nitrophenyl)quinazolin-4(3H)-one
-
at pH 7.0 and 25°C
0.0379
3-amino-2-(trifluoromethyl) quinazolin-4(3H)-one
-
at pH 7.0 and 25°C
0.0549
3-amino-2-methylquinazolin-4(3H)-one
-
at pH 7.0 and 25°C
0.128
3-hydroxy-2-isopropylquinazolin-4(3H)-one
in 100 mM Tris/HCl, pH 7.5, 2 mM CaCl2, 4% (v/v) DMSO, at 25°C
0.93
3-hydroxy-2-methylquinazolin-4(3H)-one
in 100 mM Tris/HCl, pH 7.5, 2 mM CaCl2, 4% (v/v) DMSO, at 25°C
1.7
3-methylaspirin
in 100 mM Tris/HCl, pH 7.5, 2 mM CaCl2, 4% (v/v) DMSO, at 25°C
0.0000115
3-phenyl-2-(trifluoromethyl) quinazolin-4(3H)-one
-
at pH 7.0 and 25°C
4
3-[[(1E)-(3-chlorophenyl)methylene]amino]-2-phenylquinazolin-4(3H)-one
-
at pH 7.0 and 25°C
4.81
5-bromo-N-(4-bromophenyl)-2-hydroxy-3-nitro-benzamide
-
25°C, pH 7.5
1.6
beta-phenylpropionyl-L-phenylalanine
-
pH 6.8, 25°C, enzyme contains Zn2+
0.000000068
carbobenzoxy-L-phenylalanine-phosphonamidate-L-leucyl-L-alanine
pH and temperature not specified in the publication
106
ethanimidic acid N-[4-oxo-2-phenyl-3(4H)-quinazolinyl]-ethyl ester
-
at pH 7.0 and 25°C
0.00005
N-(1-carboxy-3-phenyl-propyl)-L-leucyl-L-tryptophan
pH and temperature not specified in the publication
294
N-(2,3-dimethylphenyl)-2-hydroxy-3-nitro-benzamide
-
25°C, pH 7.5
161
N-(2,4-dimethylphenyl)-2-hydroxy-3-nitro-benzamide
-
25°C, pH 7.5
1.45
N-(2,5-dimethylphenyl)-2-hydroxy-3-nitrobenzamide
-
25°C, pH 7.5
697
N-(2-chloro-4-nitrophenyl)-2-hydroxy-3-nitro-benzamide
-
25°C, pH 7.5
0.047
N-(2-chloro-6-methylphenyl)-2-hydroxy-3-nitrobenzamide
-
25°C, pH 7.5
2.95
N-(2-ethylphenyl)-2-hydroxy-3-nitrobenzamide
-
25°C, pH 7.5
8.14
N-(5-chloro-2-methoxyphenyl)-2-hydroxy-3-nitro-benzamide
-
25°C, pH 7.5
0.0012
[(2S)-2-sulfanyl-3-phenylpropanoyl]Gly-(5-Ph)Pro
pH 8.0, 37°C
0.000042
[(2S)-2-sulfanyl-3-phenylpropanoyl]Phe-Tyr
pH 8.0, 37°C
0.000048
[(2S,R)-2-sulfanylheptanoyl]Phe-Ala
pH 8.0, 37°C
0.008
-
pH 5.0, 37°C, Co2+-bound enzyme
0.012
N-Benzyloxycarbonyl-L-phenylalanine
-
pH 5.1, 37°C, Zn2+-bound enzyme
0.16
N-Benzyloxycarbonyl-L-phenylalanine
-
pH 7.1, 37°C, Co2+-bound enzyme
0.37
N-Benzyloxycarbonyl-L-phenylalanine
-
pH 7.0, 37°C, Zn2+-bound enzyme
0.007
-
pH 5.0, 37°C, Co2+-bound enzyme
0.008
N-benzyloxycarbonyl-L-tryptophan
-
pH 5.0, 37°C, Zn2+-bound enzyme
0.087
N-benzyloxycarbonyl-L-tryptophan
-
pH 7.0, 37°C, Zn2+-bound enzyme
0.19
N-benzyloxycarbonyl-L-tryptophan
-
pH 7.0, 37°C, Zn2+-bound enzyme, in presence of 1 M NaSCN
0.21
N-benzyloxycarbonyl-L-tryptophan
-
pH 7.0, 37°C, Co2+-bound enzyme, in presence of 1 M NaSCN
0.00003
-
pH 7.2, temperature not specified in the publication
0.019
Z-L-tryptophan
-
pH 5.0, 25°C, enzyme contains Zn2+, presence of 1 M NaSCN
0.021
Z-L-tryptophan
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pH 5.0, 25°C, enzyme contains Co2+, presence of 1 M NaSCN
additional information
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detailed inhibition kinetics with Co2+ and Zn2+, overview
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additional information
additional information
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inhibition kinetics with Co2+ and Ca2+, overview
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additional information
additional information
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organic solvent inhibition kinetics, overview
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