3.4.24.25: vibriolysin
This is an abbreviated version!
For detailed information about vibriolysin, go to the full flat file.
Word Map on EC 3.4.24.25
-
3.4.24.25
-
3.4.24.4
-
thermolysin
-
cholerae
-
thermoproteolyticus
-
metalloendopeptidase
-
proteolyticus
-
thermolysin-like
- 3.4.24.25
-
3.4.24.4
- thermolysin
- cholerae
- thermoproteolyticus
- metalloendopeptidase
- proteolyticus
-
thermolysin-like
Reaction
Preferential cleavage of bonds with bulky hydrophobic groups in P2 and P1'. Phe at P1' is the most favoured residue, which distinguished this enzyme from thermolysin =
Synonyms
Aeromonas neutral protease, Aeromonas proteolytica neutral proteinase, Aeromonolysin, E495, EC 3.4.24.4, HA/protease, hAPA, hemagglutinin/protease HA/P, MCP-02, MvP1, NprV-R, Proteinase, Aeromonas proteolytica neutral, Vibriolysin
ECTree
Advanced search results
Posttranslational Modification
Posttranslational Modification on EC 3.4.24.25 - vibriolysin
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
proteolytic modification
the MvP1 propeptide undergoes both N-terminal and C-terminal processing and different C-terminal processing results in the formation of several active isoforms of the mature peptidase
proteolytic modification
-
secretion of HA/protease into the extracellular medium is a two stage process. First, the preproprotein or primary translation product is translocated through the cytoplasmic membrane with removal of its signal peptide by a Sec-dependent mechanism. Second, the proprotein folds in the periplasmic space and is secreted across the outer membrane via the type II secretion system, a multiprotein complex encoded by 12 eps (extracellular protein secretion) genes. Removal of the HA/protease propeptide and C-terminal processing is presumed to occur in the extracellular medium through an autocatalytic mechanism
proteolytic modification
-
recombinant pro-vibriolysin is cleaved to the 35 kDA mature vibriolysin
proteolytic modification
enzyme is synthesized as a preproenzyme. The propeptide inhibits the mature enzyme