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3.4.23.49: omptin

This is an abbreviated version!
For detailed information about omptin, go to the full flat file.

Word Map on EC 3.4.23.49

Reaction

Has a virtual requirement for Arg in the P1 position and a slightly less stringent preference for this residue in the P1' position, which can also contain Lys, Gly or Val. =

Synonyms

bacterial outer-membrane protease, Citrobacter rodentium outer-membrane protease, CroP, E. coli protease VII, EC 3.4.21.87, endoprotease, Gene ompT proteins, More, OmpP, OmpP protease, ompT, OmpT protease, OmpT protein, Omptin, omptin protease, outer membrane protease, Outer membrane protein 3B, outer-membrane protease, outer-membrane protease T, PgtE, Pla, plaA, protease 7, Protease A, Protease VII, Protein a, Proteins, specific or class, gene ompT, SopA

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.49 omptin

Natural Substrates Products

Natural Substrates Products on EC 3.4.23.49 - omptin

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
alpha2-antiplasmin + H2O
?
show the reaction diagram
inactivation
-
-
?
cationic antimicrobial peptides from epithelial cells or macrophages + H2O
?
show the reaction diagram
ColE2-Im2 protein complex + H2O
?
show the reaction diagram
-
a small amount of the endonuclease colicin E2 associated with the cognate immunity protein Im2, is susceptible to proteolytic cleavage by omptin. The presence of outer membrane protein BtuB is required for ColE-Im2 cleavage by omptin. The amount of colicin cleaved is greatly enhanced when ColE2 is dissociated from Im2. Omptin cleaves the C-terminal DNase domain of the toxin. Strains that over-produce OmpT are less susceptible to infection by ColE2 than by ColE2-Im2
-
-
?
colicin E1 + H2O
?
show the reaction diagram
function in degradation of colicin at the cell surface to protect sensitive cells from infection by colicins suggested
-
-
?
factor B + H2O
?
show the reaction diagram
factor H + H2O
?
show the reaction diagram
human antiprotease alpha2-antiplasmin + H2O
?
show the reaction diagram
-
involved in infection and pathogenesis
-
-
?
human circulating complement proteins + H2O
?
show the reaction diagram
-
activation of the substrate
-
-
?
human LL-37 + H2O
?
show the reaction diagram
human plasminogen + H2O
?
show the reaction diagram
-
proteolytic cleavage site CPGR*VVGGC, activation
-
-
?
human proenzyme plasminogen + H2O
?
show the reaction diagram
LL37 + H2O
?
show the reaction diagram
a human antimicrobial peptide of the cathelicidin family
-
-
?
murine cathelicidin-related antimicrobial peptide + H2O
?
show the reaction diagram
plasminogen + H2O
plasmin + ?
show the reaction diagram
plasminogen activator inhibitor-1 + H2O
?
show the reaction diagram
inactivation
-
-
?
small-molecular-weight chromogenic peptides + H2O
?
show the reaction diagram
-
OmpT, proteolytic cleavage
-
-
?
TAFI + H2O
TAFIa + ?
show the reaction diagram
TAFI is secreted into plasma as a procarboxypeptidase, it is a regulatory protein linking the coagulation and fibrinolytic systems, and TAFI is protective in septic yersionosis. PptE cleaves at the C-terminal region of TAFI and reduces its activation to TAFIa
-
-
?
tissue factor pathway inhibitor + H2O
?
show the reaction diagram
additional information
?
-