3.4.23.49: omptin

This is an abbreviated version!
For detailed information about omptin, go to the full flat file.

Word Map on EC 3.4.23.49

Reaction

Has a virtual requirement for Arg in the P1 position and a slightly less stringent preference for this residue in the P1' position, which can also contain Lys, Gly or Val. =

Synonyms

More, Protease A, Gene ompT proteins, OmpT protease, Proteins, specific or class, gene ompT, E. coli protease VII, Protein a, Pla, Protease VII, Omptin, Outer membrane protein 3B, endoprotease, plaA, ompT, OmpP, SopA, PgtE, outer-membrane protease T, OmpT protein, OmpP protease, omptin protease, CroP, Citrobacter rodentium outer-membrane protease, outer membrane protease, protease 7, outer-membrane protease, bacterial outer-membrane protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.49 omptin

Inhibitors

Inhibitors on EC 3.4.23.49 - omptin

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-aminobenzoyl-A-(L)R-(D)R-A-3-[(2,4-dinitrophenyl)amino]-L-alanyl-Gly
-
-
Al3+
-
1 mM, 47% residual activity
Aprotinin
arginine
-
-
benzamidine
-
-
calf thymus histone H2B
-
growth inhibitory activity against bacterial gene expressing Escherichia coli with calculated 50% growth inhibitory concentrations of 3.8 microM. Histone H2B penetrates the cell membrane of JCM5491 OmpT+ cells
-
calf thymus histone H3
-
growth inhibitory activity against bacterial gene expressing Escherichia coli with calculated 50% growth inhibitory concentrations of 10 microM. Histones H3 and H4 remain on the cell surface and subsequently disrupt the cell membrane structure with bleb formation in a manner similar to general antimicrobial peptides
-
calf thymus histone H4
-
growth inhibitory activity against bacterial gene expressing Escherichia coli with calculated 50% growth inhibitory concentrations of 12.7 microM. Histones H3 and H4 remain on the cell surface and subsequently disrupt the cell membrane structure with bleb formation in a manner similar to general antimicrobial peptides
-
CuCl2
-
significant inhibition at 1 mM
diisopropylfluorophosphate
guanidine hydrochloride
-
50 mM, 40% residual activity
lipopolysaccharide
NaCl
-
optimal activity in absence of NaCl, 80% inhibition by 0.15 M NaCl
pepstatin A
-
5 mM, complete loss of activity
phenylmethylsulfonyl fluoride
SDS
-
0.02%, complete loss of activity
tosyl-L-phenylalanine chloromethyl ketone
-
-
Tween 20
-
up to 1%, 80% residual activity
Urea
-
50 mM, 72% residual activity
ZnCl2
-
significant inhibition at 1 mM
additional information
-