3.4.23.3: gastricsin
This is an abbreviated version!
For detailed information about gastricsin, go to the full flat file.
Word Map on EC 3.4.23.3
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3.4.23.3
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mucosa
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pylori
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helicobacter
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gastritis
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stomach
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atrophic
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gastrin
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ulcer
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zymogen
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proteinases
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endoscopy
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duodenal
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peptic
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metaplasia
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fundic
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gastrin-17
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pepstatin
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antral
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pylori-positive
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dyspeptic
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prochymosin
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chymosin
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gastroduodenal
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3.4.23.1
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diffuse-type
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isozymogens
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pylori-negative
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prosegment
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anti-helicobacter
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medicine
- 3.4.23.3
- mucosa
- pylori
- helicobacter
- gastritis
- stomach
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atrophic
- gastrin
- ulcer
- zymogen
- proteinases
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endoscopy
- duodenal
-
peptic
- metaplasia
- fundic
- gastrin-17
- pepstatin
-
antral
-
pylori-positive
-
dyspeptic
- prochymosin
- chymosin
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gastroduodenal
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3.4.23.1
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diffuse-type
-
isozymogens
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pylori-negative
- prosegment
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anti-helicobacter
- medicine
Reaction
additional information restricted specificity than pepsin A, but shows preferential cleavage at Tyr-/- bonds. High activity on hemoglobin =
Synonyms
EC 3.4.4.22, More, parapepsin II, pepsin C, pepsin II, pepsinogen C, pepsinogen II, PGC, pig parapepsin II, progastricsin, seminal pepsin
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3.4.23.3 gastricsinAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.4.23.3 - gastricsin
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
oxidized insulin B chain + H2O
?
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major site of attack are the bonds Tyr16-Leu17, 86%, Phe24-Phe25, 82%, His10-Leu11, 46%, Ala14-Leu15, 44%, Gly13-Ala14, 34%
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?
additional information
?
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clotting activity with kappa-casein is only half of that of chymosin and pepsin A
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?
additional information
?
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role of this gastric digestive enzyme in the regulation of food intake
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?
additional information
?
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progastricsin is responsible for the autoproteolysis of seminal fluid proteins under acidic conditions. This suggests that the function of the enzyme is to degrade seminal fluid proteins deposited in the vagina, this in turn may decrease the antigenic load in the vagina and prevent immuno-infertility
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?
additional information
?
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pepsinogen C expression by human mammary epithelium may be involved in the development of breast diseases
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?
additional information
?
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the enzyme shows very high gastric antibacterial efficiency against Helicobacter pylori at pH 2.0
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?
additional information
?
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transcriptional regulation of the pepsinogen C gene, presence of a DNA-binding protein that specifically binds to the promoter region of the rat pepsinogen C gene
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?
