3.4.23.3: gastricsin
This is an abbreviated version!
For detailed information about gastricsin, go to the full flat file.
Word Map on EC 3.4.23.3
-
3.4.23.3
-
mucosa
-
pylori
-
helicobacter
-
gastritis
-
stomach
-
atrophic
-
gastrin
-
ulcer
-
zymogen
-
proteinases
-
endoscopy
-
duodenal
-
peptic
-
metaplasia
-
fundic
-
gastrin-17
-
pepstatin
-
antral
-
pylori-positive
-
dyspeptic
-
prochymosin
-
chymosin
-
gastroduodenal
-
3.4.23.1
-
diffuse-type
-
isozymogens
-
pylori-negative
-
prosegment
-
anti-helicobacter
-
medicine
- 3.4.23.3
- mucosa
- pylori
- helicobacter
- gastritis
- stomach
-
atrophic
- gastrin
- ulcer
- zymogen
- proteinases
-
endoscopy
- duodenal
-
peptic
- metaplasia
- fundic
- gastrin-17
- pepstatin
-
antral
-
pylori-positive
-
dyspeptic
- prochymosin
- chymosin
-
gastroduodenal
-
3.4.23.1
-
diffuse-type
-
isozymogens
-
pylori-negative
- prosegment
-
anti-helicobacter
- medicine
Reaction
additional information restricted specificity than pepsin A, but shows preferential cleavage at Tyr-/- bonds. High activity on hemoglobin =
Synonyms
EC 3.4.4.22, More, parapepsin II, pepsin C, pepsin II, pepsinogen C, pepsinogen II, PGC, pig parapepsin II, progastricsin, seminal pepsin
ECTree
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Reference on EC 3.4.23.3 - gastricsin
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jones, A.T.; Green, B.N.; Wood, S.P.; Roberts, N.B.
The amino terminal sequences of acid proteases-human pepsin and gastricsin and the protease of Rhizopus chinensis
Aspartic Proteinases: Structure, Function, Biology and Biomedical Implications (Takahashi, K. , ed. ), Plenum Press, New York
83-89
1995
Homo sapiens
-
James, M.; Moore, S.; Sielecki, A.; Chernaia, M.; Tarasova, N.
Pepsinogens and pepsins from house musk shrew, Suncus murinus: purification, characterization, determination of the amino-acid sequences of the activation segments, and analysis of proteolytic specificities
Aspartic Proteinases: Structure, Function, Biology and Biomedical Implications (Takahashi, K. , ed. ), Plenum Press, New York
11-18
1995
Homo sapiens
-
Sepulveda, P.; Jackson, K.W.; Tang, J.
The amino terminal sequences of acid proteases-human pepsin and gastricsin and the protease of rhizopus chinensis
Biochem. Biophys. Res. Commun.
63
1106-1112
1975
Homo sapiens
Narita, Y.; Oda, S.; Moriyama, A.; Takenaka, O.; Kageyama, T.
Pepsinogens and pepsins from house musk shrew, Suncus murinus: Purification, characterization, determination of the amino-acid sequences of the activation segments, and analysis of proteolytic specificities
J. Biochem.
121
1010-1017
1997
Suncus murinus
Reid, W.A.; Vongsorasak, L.; Svasti, J.; Valler, M.J.; Kay, J.
Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate
Cell Tissue Res.
236
597-600
1984
Homo sapiens
Chiang, L.; Contreras, L.; Chiang, J.; Ward, P.H.
Human prostatic gastricsinogen: The precursor of seminal fluid acid proteinase
Arch. Biochem. Biophys.
210
14-20
1981
Homo sapiens
Cooper, J.B.; Foundling, S.I.; Blundell, T.L.; Boger, J.; Jupp, R.A.; Kay, J.
X-ray studies of aspartic proteinase-statine inhibitor complexes
Biochemistry
28
8596-8603
1989
Homo sapiens
Ishihara, T.; Ichihara, Y.; Hayano, T.; Katsura, I.; Sogawa, K.; Fujii-Kuriyama, Y.; Takahashi, K.
Primary structure and transcriptional regulation of rat pepsinogen C gene
J. Biol. Chem.
264
10193-10199
1989
Rattus norvegicus
Kucerova, Z.; Pohl, J.; Korbova, L.
Separation of human pepsin and gastricsin by affinity chromatography with an immobilized synthetic inhibitor
J. Chromatogr.
376
409-412
1986
Homo sapiens
Dunn, B.M.; Kay, J.
Design, synthesis and analysis of new synthetic substrates for the aspartic proteinases
Biochem. Soc. Trans.
13
1041-1043
1985
Sus scrofa
Martin, P.; Trieu-Cuot, P.; Collin, J.C.; Ribadeau Dumas, B.
Purification and characterization of bovine gastricsin
Eur. J. Biochem.
122
31-39
1982
Bos taurus
Ryle, A.P.; Hamilton, M.P.
Pepsinogen C and pepsin C. Further purification and amino acid composition
Biochem. J.
101
176-183
1966
Sus scrofa
Muto, N.; Murayama, K.; Akahane, K.; Tani, S.
Biochemical and immunological characterizations of rat pepsinogens and pepsins
J. Biochem.
87
717-723
1980
Rattus norvegicus
Ryle, A.P.; Auffret, C.A.
The specificity of some pig and human pepsins towards synthetic peptide substrates
Biochem. J.
179
247-249
1979
Homo sapiens, Sus scrofa
Auffret, C.A.; Ryle, A.P.
The catalytic activity of pig pepsin C towards small synthetic substrates
Biochem. J.
179
239-246
1979
Sus scrofa
Richmond, V.; Tang, J.; Wolf, S.; Trucco, R.E.; Caputto, R.
Chromatographic isolation of gastricsin, the proteolytic enzyme from gastric juice with pH optimum 3.2
Biochim. Biophys. Acta
29
453-454
1958
Homo sapiens
Ryle, A.P.; Leclerc, J.; Falla, F.
The substrate specificity of pepsin C
Biochem. J.
110
4
1968
Sus scrofa
Suzuki, M.; Narita, Y.; Oda, S.; Moriyama, A.; Takenaka, O.; Kageyama, T.
Purification and characterization of goat pepsinogens and pepsins
Comp. Biochem. Physiol. B
122
453-460
1999
Capra hircus
Sanchez, L.M.; Freije, J.P.; Merino, A.M.; Vizoso, F.; Foltmann, B.; Lopez-Otin, C.
Isolation and characterization of a pepsin C zymogen produced by human breast tissues
J. Biol. Chem.
267
24725-24731
1992
Homo sapiens
Hayano, T.; Sogawa, K.; Ichihara, Y.; Fujii-Kuriyama, Y.; Takahashi, K.
Primary structure of human pepsinogen C gene
J. Biol. Chem.
263
1382-1385
1988
Homo sapiens
Foltmann, B.; Drohse, H.B.; Nielsen, P.K.; James, M.N.G.
Separation of porcine pepsinogen A and progastricsin. Sequencing of the first 73 amino acid residues in progastricsin
Biochim. Biophys. Acta
1121
75-82
1992
Sus scrofa
Szecsi, P.B.; Lilja, H.
Gastricsin-mediated proteolytic degradation of human seminal fluid proteins at pH levels found in the human vagina
J. Androl.
14
351-358
1993
Homo sapiens
Rao, C.M.; Scarborough, P.E.; Kay, J.; Batley, B.; Rapundalo, S.; Klutchko, S.; Taylor, M.D.; Lunney, E.A.; Humblet, C.C.; Dunn, B.M.
Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation
J. Med. Chem.
36
2614-2620
1993
Homo sapiens
Kageyama, T.; Takahashi, K.
Pepsinogen C and pepsin C from gastric mucosa of Japanese monkey. Purification and characterization
J. Biochem.
80
983-992
1976
Macaca fuscata
Ichihara, Y.; Sogawa, K.; Morohashi, K.; Fujii-Kuriyama, Y.; Takahashi, K.
Nucleotide sequence of a nearly full-length cDNA coding for pepsinogen of rat gastric mucosa
Eur. J. Biochem.
161
7-12
1986
Rattus norvegicus
Taggart, R.T.; Cass, L.G.; Mohandas, P.; Derby, P.J.; Barr, P.J.; Pals, G.; Bell, G.
Human pepsinogen C (progastricsin). Isolation of cDNA clones, localization to chromosome 6, and sequence homology with pepsinogen A
J. Biol. Chem.
264
375-379
1989
Homo sapiens
Athauda, S.B.; Nishigai, M.; Arakawa, H.; Ikai, A.; Ukai, M.; Takahashi, K.
Inhibition of human pepsin and gastricsin by alpha2-macroglobulin
J. Enzyme Inhib. Med. Chem.
18
219-224
2003
Homo sapiens
Schreiber, S.; Buecker, R.; Groll, C.; Azevedo-Vethacke, M.; Scheid, P.; Gatermann, S.; Josenhans, C.; Suerbaum, S.
Gastric antibacterial efficiency is different for pepsin A and C
Arch. Microbiol.
184
335-340
2006
Homo sapiens
Tang, J.
Gastricsin
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. )
1
38-43
2004
Homo sapiens, Macaca fuscata, Sus scrofa, Xenopus laevis
-
Terova, G.; Rimoldi, S.; Larghi, S.; Bernardini, G.; Gornati, R.; Saroglia, M.
Regulation of progastricsin mRNA levels in sea bass (Dicentrarchus labrax) in response to fluctuations in food availability
Biochem. Biophys. Res. Commun.
363
591-596
2007
Dicentrarchus labrax
Feng, S.; Li, W.; Lin, H.
Characterization and expression of the pepsinogen C gene and determination of pepsin-like enzyme activity from orange-spotted grouper (Epinephelus coioides)
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
149
275-284
2008
Epinephelus coioides
Filuszova, M.; Kucerova, Z.; Ticha, M.
Peptide inhibitor modified magnetic particles for pepsin separation
J. Sep. Sci.
32
2017-2021
2009
Homo sapiens, Rattus norvegicus
Hassan, M.; Toor, A.; Ahmad, F.
Progastriscin: Structure, function, and its role in tumor progression
J. Mol. Cell Biol.
2
118-127
2010
Homo sapiens (P20142), Homo sapiens
Foltz, E.; Azad, S.; Everett, M.L.; Holzknecht, Z.E.; Sanders, N.L.; Thompson, J.W.; Dubois, L.G.; Parker, W.; Keshavjee, S.; Palmer, S.M.; Davis, R.D.; Lin, S.S.
An assessment of human gastric fluid composition as a function of PPI usage
Physiol. Rep.
3
e12269
2015
Homo sapiens
Shen, S.; Jiang, J.; Yuan, Y.
Pepsinogen C expression, regulation and its relationship with cancer
Cancer Cell Int.
17
57
2017
Homo sapiens
Chen, H.; Zhu, H.R.; Yu, X.N.; Shi, X.; Bilegsaikhan, E.; Guo, H.Y.; Huang, R.Z.; Liu, T.T.; Shen, X.Z.; Zhu, J.M.
Overexpressed pepsinogen C is associated with poor prognosis in human hepatocellular carcinoma a tissue microarray study
Cancer Manag. Res.
11
2927-2934
2019
Homo sapiens
Jiang, J.; Shen, S.; Dong, N.; Liu, J.; Xu, Q.; Sun, L.; Yuan, Y.
Correlation between negative expression of pepsinogen C and a series of phenotypic markers of gastric cancer in different gastric diseases
Cancer Med.
7
4068-4076
2018
Homo sapiens
Hallal, C.; Chaves, V.S.; Borges, G.C.; Werlang, I.C.; Fontella, F.U.; Matte, U.; Goldani, M.Z.; Carvalho, P.R.; Trotta, E.A.; Piva, J.P.; Barros, S.G.S.; Goldani, H.A.S.
Acid and weakly acidic gastroesophageal reflux and pepsin isoforms (A and C) in tracheal secretions of critically ill children
Chest
148
333-339
2015
Homo sapiens
Islam, M.R.; Kim, N.S.; Jung, J.W.; Kim, H.B.; Han, S.C.; Yang, M.S.
Spontaneous pepsin C-catalyzed activation of human pepsinogen C in transgenic rice cell suspension culture Production and characterization of human pepsin C
Enzyme Microb. Technol.
108
66-73
2018
Homo sapiens (P20142), Homo sapiens
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