3.4.23.25: saccharopepsin

This is an abbreviated version!
For detailed information about saccharopepsin, go to the full flat file.

Reaction

Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu-/-Val-Tyr bond in a synthetic substrate. Does not act on esters of Tyr or Arg =

Synonyms

Acid protease, Aspartate protease, Aspartic proteinase, Aspartic proteinase yscA, EC 3.4.23.6, EC 3.4.23.8, EC 3.4.4.17, Pep4, PEP4 gene product, Pep4p, Pep4p vacuolar proteinase, pepsin-like aspartic proteinase, PRA, preproPrA, proPrA, Protease A, Proteinase A, proteinase A precursor, Proteinase yscA, Proteinase, yeast A, proteinase-A, pseudo-proteinase A, Saccharomyces aspartic proteinase, Saccharomyces cerevisiae aspartic proteinase A, saccharopepsin, vacuolar aspartic proteinase, yeast aspartic proteinase A, Yeast endopeptidase A, yeast proteinase, Yeast proteinase A

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.25 saccharopepsin

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Results	in table
2	Activating Compound
18	AA Sequence
9	Application
1	CAS Registry Number
5	Cloned(Commentary)
6	Crystallization (Commentary)
3	Expression
2	General Information
3	General Stability
1	IC50 Value
50	Inhibitors
47	Ki Value [mM]
39	KM Value [mM]
21	Localization
18	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
76	Organism
12	PDB ID
14	pH Optimum
4	pH Range
4	pH Stability
9	Posttranslational Modification
5	Protein Variants
13	Purification (Commentary)
3	Reaction
1	Reaction Type
43	Reference
1	Source Tissue
4	Specific Activity [micromol/min/mg]
2	Storage Stability
115	Substrates and Products (Substrate)
15	Subunits
75	Synonyms
2	Temperature Optimum [°C]
3	Temperature Stability [°C]
40	Turnover Number [1/s]

pH Stability

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pH Stability on EC 3.4.23.25 - saccharopepsin

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3

Saccharomyces cerevisiae

-

25°C, 48 h, 80% loss of activity

30697

3.6 - 6.8

Saccharomyces cerevisiae

-

37°C, optimal pH for stability

30710

4 - 6

Saccharomyces cerevisiae

-

25°C, stable

30697

5.5

Saccharomyces cerevisiae

-

2 h, stable below 45°C

30697