3.4.23.25: saccharopepsin

This is an abbreviated version!
For detailed information about saccharopepsin, go to the full flat file.

Word Map on EC 3.4.23.25

Reaction

Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu-/-Val-Tyr bond in a synthetic substrate. Does not act on esters of Tyr or Arg =

Synonyms

Protease A, Proteinase A, EC 3.4.23.6, Yeast endopeptidase A, Saccharomyces aspartic proteinase, Aspartic proteinase yscA, Proteinase yscA, Proteinase, yeast A, Saccharomyces cerevisiae aspartic proteinase A, Yeast proteinase A, PRA, EC 3.4.23.8, Acid protease, Aspartate protease, Aspartic proteinase, vacuolar aspartic proteinase, proteinase-A, yeast proteinase, PEP4 gene product, pseudo-proteinase A, proteinase A precursor, pepsin-like aspartic proteinase, preproPrA, proPrA, Pep4p vacuolar proteinase, Pep4p, saccharopepsin, yeast aspartic proteinase A, Pep4

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.25 saccharopepsin

Natural Substrates Products

Natural Substrates Products on EC 3.4.23.25 - saccharopepsin

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
lipid transfer protein 1 + H2O
?
show the reaction diagram
procarboxypeptidase Y + H2O
propeptide of carboxypeptidase Y + carboxypeptidase Y
show the reaction diagram
proproteinase A + H2O
propeptide of proteinase A + proteinase A
show the reaction diagram
proproteinase A + H2O
pseudo-proteinaseA + peptide
show the reaction diagram
autoactivation of the enzyme yields a functional protein cleaved after Ser68, autoactivation can occur in rare situations when PrB is unable to activate PrA
Ser68 is the N-terminal amino acid
-
?
proproteinase B + H2O
propeptide of proteinase B + proteinase B
show the reaction diagram
Spt7p + H2O
?
show the reaction diagram
-
the enzyme is required for cleavage of Spt7p subunit within SAGA in vitro into SLIK-related Spt7p
-
-
?
additional information
?
-