3.4.23.21: Rhizopuspepsin
This is an abbreviated version!
For detailed information about Rhizopuspepsin, go to the full flat file.
Word Map on EC 3.4.23.21
Reaction
hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave Gln4-His, but does cleave His10-/-Leu and Val12-/-Glu in B chain of insulin =
Synonyms
Aspartate protease, aspartic peptidase, EC 3.4.23.6, EC 3.4.23.9, EC 3.4.4.17, EC 3.4.99.25, More, Neurase, Proteinase, Rhizopus acid, Rhizopus acid protease, Rhizopus acid proteinase, Rhizopus aspartic proteinase, rhizopuspepsinogen
ECTree
3.4.23.21 RhizopuspepsinAdvanced search results
results (
results (Reference
top
Reference on EC 3.4.23.21 - Rhizopuspepsin
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Majima, E.; Oda, K.; Murao, S.; Ichishima, E.
Comparative study on the specificities of several fungal aspartic and acidic proteinases towards the tetradecapeptide of a renin substrate
Agric. Biol. Chem.
52
787-793
1988
Rhizopus sp.
-
Takahashi, K.; Chang, W.J.
The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy) propane and pepstatin
J. Biochem.
80
497-506
1976
Rhizopus microsporus var. chinensis
Hofmann, T.; Hodges, R.S.; James, M.N.G.
Effect of pH on the activities of penicillopepsin and Rhizopus pepsin and a proposal for the productive substrate binding mode in penicillopepsin
Biochemistry
23
635-643
1984
Rhizopus sp.
Tsuru, D.; Hattori, A.; Tsuji, H.; Yamamoto, T.; Fukumoto, J.
Mold proteases. II. Substrate specificity of acid protease of Rhizopus chinensis
Agric. Biol. Chem.
33
1419-1426
1969
Rhizopus microsporus var. chinensis
-
Kurono, Y.; Chidimatsu, M.; Korikoshi, K.; Ikeda, Y.
Isolation of a protease from a Rhizopus product
Agric. Biol. Chem.
35
1668-1675
1971
Rhizopus niveus
-
Suguna, K.; Padlan, E.A.; Smith, C.W.; Carlson, W.D.; Davies, D.R.
Binding of a reduced peptide inhibitor to the aspartic proteinase from Rhizopus chinensis: implications for a mechanism of action
Proc. Natl. Acad. Sci. USA
84
7009-7013
1987
Rhizopus microsporus var. chinensis
Gripon, J.C.; Rhee, S.H.; Hofmann, T.
N-terminal amino acid sequences of acid proteases: acid proteases from Penicillium roqueforti and Rhizopus chinensis and alignment with penicillopepsin and mammalian proteases
Can. J. Biochem.
55
504-506
1977
Rhizopus microsporus var. chinensis
Mizobe, F.; Takahashi, K.; Ando, T.
The structure and function of acid proteases. Specific inactivation of an acid protease from Rhizopus chinensis by diazoacetyl-DL-norleucine methyl ester
J. Biochem.
73
61-68
1973
Rhizopus microsporus var. chinensis
Takahashi, K.
Determination of the amino acid sequences of the two major isozymes of rhizopuspepsin
J. Biochem.
103
162-167
1988
Rhizopus microsporus var. chinensis
Horiuchi, H.; Yanai, K.; Okazaki, T.; Takagi, M.; Yano, K.
Isolation and sequencing of a genomic clone encoding aspartic proteinase of Rhizopus niveus
J. Bacteriol.
170
272-278
1988
Rhizopus niveus
Subramanian, E.; Swan, I.D.A.; Davies, D.R.
The crystal at 5.5A resolution of an acid-protease from Rhizopus chinensis
Biochem. Biophys. Res. Commun.
68
875-880
1976
Rhizopus microsporus var. chinensis
Takahashi, K.
The amino acid sequence of rhizopuspepsin, an aspartic proteinase from Rhizopus chinensis
J. Biol. Chem.
262
1468-1478
1987
Rhizopus microsporus var. chinensis
Subramanian, E.; Swan, I.D.A.; Liu, M.; Davies, D.R.; Jenkins, J.A.; Tickle, I.J.; Blundell, T.L.
Homology among acid proteases: comparison of crystal structures at 3A resolution of acid proteases from Rhizopus chinensis and Endothia parasitica
Proc. Natl. Acad. Sci. USA
74
556-559
1977
Rhizopus microsporus var. chinensis
Bott, R.; Subramanian, E.; Davies, D.R.
Three-dimensional structure of the complex of the Rhizopus chinensis carboxyl proteinase and pepstatin at 2.5-A resolution
Biochemistry
21
6956-6962
1982
Rhizopus microsporus var. chinensis
Delaney, R.; Wong, R.N.S.; Meng, G.; Wu, N.; Tang, J.
Amino acid sequence of rhizopuspepsin isozyme pI 5
J. Biol. Chem.
262
1461-1467
1987
Rhizopus microsporus var. chinensis
Suguna, K.; Bott, R.R.; Padlan, E.A.; Subramanian, E.; Sheriff, S.; Cohen, G.H.; Davies, D.R.
Structure and refinement at 1.8 A resolution of the aspartic proteinase from Rhizopus chinensis
J. Mol. Biol.
196
877-900
1987
Rhizopus microsporus var. chinensis
Ichishima, E.; Ojima, M.; Yamagata, Y.; Hanzawa, S.; Nakamura, T.
Molecular and enzymatic properties of an aspartic proteinase from Rhizopus hangchow
Phytochemistry
38
27-30
1995
Rhizopus arrhizus
Nakamura, S.; Takahashi, K.
The structure and function of acid proteases. IX. Isolation and amino acid sequences of the peptides containing the active site aspartyl residues reactive with diazoacetyl-DL-norleucine methyl ester and 1,2-epoxy-3-(p-nitrophenoxy)propane in Rhizopus chinensis acid protease
J. Biochem.
84
1593-1600
1978
Rhizopus microsporus var. chinensis
Nakamura, S.; Takahshi, K.
Amino acid sequences around 1, 2-epoxy-3-(p-nitrophenoxy)propane-reactive residues in rhizopus chinensis acid protease: homology with pepsin and rennin
J. Biochem.
81
805-807
1977
Rhizopus microsporus var. chinensis
Nakatani, H.; Hiromi, K.; Kitagishi, K.
Kinetic study on the interaction of Rhizopus chinensis aspartic protease with Streptomyces pepsin inhibitor (acetylpepstatin)
Arch. Biochem. Biophys.
263
311-314
1988
Rhizopus microsporus var. chinensis
Lowther, W.T.; Majer, P.; Dunn, B.M.
Engineering the substrate specificity of rhizopuspepsin: the role of Asp 77 of fungal aspartic proteinases in facilitating the cleavage of oligopeptide substrates with lysine in P1
Protein Sci.
4
689-702
1995
Rhizopus sp.
Sing, Y.L.K.; Kroviarski, Y.; Cochet, S.; Dhermy, D.; Bertrand, O.
High-performance hydrophobic interaction chromatography of proteins on reversed-phase supports coated with non-ionic surfactants of polyoxyethylene type. Purification of a fungal aspartic proteinase
J. Chromatogr.
598
181-187
1992
Rhizopus sp.
Ohtsuru, M.; Tang, J.; Delaney, R.
Purification and characterization of rhizopuspepsin isozymes from a liquid culture of Rhizopus chinensis
Int. J. Biochem.
14
925-932
1982
Rhizopus microsporus var. chinensis
Graham, J.E.S.; Sodek, J.; Hofmann, T.
Rhizopus acid proteinases (rhizopus-pepsins): properties and homology with other acid proteinases
Can. J. Biochem.
51
789-796
1973
Rhizopus microsporus var. chinensis
Prasad, B.V.; Suguna, K.
Effect of pH on the structure of rhizopuspepsin
Acta Crystallogr. Sect. D
59
1755-1761
2003
Rhizopus sp.
Kalra, P.; Das, A.; Jayaram, B.
Free-energy analysis of enzyme-inhibitor binding: aspartic proteinase-pepstatin complexes
Appl. Biochem. Biotechnol.
96
93-108
2001
Rhizopus sp.
Bhatt, D.; Dunn, B.M.
Chimeric aspartic proteinases and active site binding
Bioorg. Chem.
28
374-393
2000
Rhizopus sp.
Flentke, G.R.; Glinski, J.; Satyshur, K.; Rich, D.H.
Purification and crystallization of rhizopuspepsin: the use of nickel chelation chromatography to select for catalytically active species
Protein Expr. Purif.
16
213-220
1999
Rhizopus sp.
Lowther, W.T.; Dunn, B.M.
The promiscuous active site specificity/binding preferences of the fungal aspartic proteinase, Rhizopuspepsin
Protein Pept. Lett.
5
303-316
1998
Rhizopus microsporus var. chinensis
-
Athauda, S.B.P.; Takahashi, K.
Cleavage specificities of aspartic proteinases toward oxidized insulin B chain at different pH values
Protein Pept. Lett.
9
289-294
2002
Rhizopus sp.
Dunn, B.M.
Rhizopuspepsin
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. )
1
108-111
2004
Rhizopus arrhizus, Rhizopus microsporus var. chinensis, Rhizopus niveus
-
Kumar, S.; Sharma, N.S.; Saharan, M.R.; Singh, R.
Extracellular acid protease from Rhizopus oryzae: purification and characterization
Process Biochem.
40
1701-1705
2005
Rhizopus arrhizus
-
da Silva, R.R.; Souto, T.B.; de Oliveira, T.B.; de Oliveira, L.C.; Karcher, D.; Juliano, M.A.; Juliano, L.; de Oliveira, A.H.; Rodrigues, A.; Rosa, J.C.; Cabral, H.
Evaluation of the catalytic specificity, biochemical properties, and milk clotting abilities of an aspartic peptidase from Rhizomucor miehei
J. Ind. Microbiol. Biotechnol.
43
1059-1069
2016
Rhizomucor miehei
Almeida, C.A.; Azevedo, M.M.B.; Chaves, F.C.M.; Roseo de Oliveira, M.; Rodrigues, I.A.; Bizzo, H.R.; Gama, P.E.; Alviano, D.S.; Alviano, C.S.
Piper essential oils inhibit Rhizopus oryzae growth, biofilm formation, and rhizopuspepsin activity
Can. J. Infect. Dis. Med. Microbiol.
2018
5295619
2018
Rhizopus arrhizus
html completed
