3.4.23.17: Pro-opiomelanocortin converting enzyme
This is an abbreviated version!
For detailed information about Pro-opiomelanocortin converting enzyme, go to the full flat file.
Word Map on EC 3.4.23.17
-
3.4.23.17
-
lobe
-
pituitary
-
beta-endorphin
-
beta-lipotropin
-
residue-specific
-
acth
-
parish
-
pepstatin
-
lys-arg
-
adrenocorticotropin
-
tuteja
-
cooh-terminal
-
glycopeptide
-
endoprotease
-
furin
-
alpha-melanotropin
-
convertase
- 3.4.23.17
- lobe
- pituitary
- beta-endorphin
- beta-lipotropin
-
residue-specific
- acth
-
parish
- pepstatin
- lys-arg
- adrenocorticotropin
-
tuteja
-
cooh-terminal
- glycopeptide
- endoprotease
- furin
-
alpha-melanotropin
-
convertase
Reaction
Cleavage at paired basic residues in certain prohormones, either between them, or on the carboxyl side =
Synonyms
EC 3.4.99.38, More, PCE, POMC converting enzyme, Pro-opiomelanocortin-converting enzyme, Prohormone converting enzyme, Proopiomelanocortin proteinase, Proteinase, proopiomelanocortin, yapsin A
ECTree
Advanced search results
Substrates Products
Substrates Products on EC 3.4.23.17 - Pro-opiomelanocortin converting enzyme
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
NH2-terminal pro-opiomelanocortin1-77 + H2O
Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
pro-insulin + H2O
insulin chain A + insulin chain B
-
cleavage of a Lys-Arg-/- and Arg-Arg-/- bonds
-
-
?
pro-vasopressin + H2O
neurophysin + glycopeptide
-
cleavage at a monobasic residue
-
-
?
pro-vasopressin + H2O
vasopressin + pro-sequence of vasopressin
-
cleavage of a Lys-Arg-/- bond
-
-
?
Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
O-linked glycosylation at Thr45 greatly inhibits the ability to cleave the Arg49-Lys50 bond
-
-
?
NH2-terminal pro-opiomelanocortin1-77 + H2O
Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
preferential cleavage between Arg49-Lys50
-
-
?
NH2-terminal pro-opiomelanocortin1-77 + H2O
Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
preferential cleavage between Arg49-Lys50
+ gamma-melanotropin, minor product
?
NH2-terminal pro-opiomelanocortin1-77 + H2O
Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
O-linked glycosylation at Thr45 greatly inhibits the ability to cleave the Arg49-Lys50 bond
-
-
?
NH2-terminal pro-opiomelanocortin1-77 + H2O
Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
-
-
?
NH2-terminal pro-opiomelanocortin1-77 + H2O
Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
-
-
?
Pro-insulin + H2O
Insulin A-chain + insulin B-chain
-
-
enzyme cleaves pro-insulin at the Lys-Arg pair to yield the A chain of insulin and at the Arg-Arg pair to yield the B-chain and the A-chain linked to C-chain (A-C) intermediate
?
?
-
may function as a pro-opiomelanocortin processing enzyme in the pituitary intermediate lobe
-
-
?
Pro-opiomelanocortin + H2O
?
-
physiological role of PC1 and PC2 as distinct proprotein convertases acting alone or together to produce a set of tissue-specific maturation products in the brain and in the peripheral tissues
-
-
?
Pro-opiomelanocortin + H2O
Adrenocorticotropin + beta-lipotropin
-
-
a 27000 and 22000 Da band detected by anti-N-proopiomelanocortin immunoblots and to 26000 Da, 22000 Da and 14000 DA bands that are immunoreactive with anti-beta-lipotropin
?
Pro-opiomelanocortin + H2O
Adrenocorticotropin + beta-lipotropin
-
cleaves the peptide bonds either between the Lys and Arg or on the carboxyl side of the Arg at Lys-Arg pairs of pro-opiomelanocortin
+ beta-endorphin + MW 16000 NH2-terminal glycopeptide, ACTH of MW 21000-23000, 13000 and 4500
?
Pro-opiomelanocortin + H2O
Adrenocorticotropin + beta-lipotropin
-
-
PC2: beta-endorphin + an N-terminally extended corticotropin containing the joining peptide + either alpha-melanotropin or desacetyl-alpha-melanotropin, PC2 cleaves at the five pairs of basic residues, PC1 cleaves two of them preferentially, PC1: corticotropin + beta-lipotropin
?
Pro-opiomelanocortin + H2O
Adrenocorticotropin + beta-lipotropin
-
-
-
?
Pro-opiomelanocortin + H2O
Adrenocorticotropin + beta-lipotropin
-
-
+ alpha-melanotropin MW 16000 + NH2-terminal glycopeptide + an endorphin-related peptide, ACTH of MW 21000 and 13000
?
Pro-opiomelanocortin + H2O
Adrenocorticotropin + beta-lipotropin
-
-
-
?
Pro-opiomelanocortin + H2O
Adrenocorticotropin + beta-lipotropin
-
-
-
?
opiomelanocortin + pro-sequence of opiomelanocortin
-
-
-
-
?
pro-opiomelanocortin + H2O
opiomelanocortin + pro-sequence of opiomelanocortin
-
hormone activation
-
-
?
Provasopressin + H2O
Arginine vasopressin-Gly10-Lys11-Arg12
-
cleavage occurs primarily on the carboxyl side of the arginine in the pair of Lys-Arg basic residues separating the vasopressin peptide from the neurophysin moiety in the precursor
major product
?
Provasopressin + H2O
Arginine vasopressin-Gly10-Lys11-Arg12
-
human vasopressin prohormone
major product
?
Small synthetic peptides with paired basic residues + H2O
?
-
-
-
-
?
Small synthetic peptides with paired basic residues + H2O
?
-
-
-
-
?
additional information
-
-
cleavage at two of the three pairs of basic residues of human beta-lipotropin, at Lys37-Lys38 and Lys57-Arg58, but not at Lys86-Lys87, the cleavage at Lys57-Arg58 occurs primarily between these basic residues
at enzyme concentration of 20 ng/0.1 ml: gamma-lipotropin + a beta-melanotropin linked to beta-endorphin intermediate + beta-endorpin, at enzyme concentration of 40 ng/0.1 ml: complete cleavage to yield beta-endorphin + beta-melanotrophin
?
Human beta-lipotropin + H2O
additional information
-
-
-
beta-endorphin(1-31) + beta-endorphin(1-29) + beta-endorphin(1-28) + gamma-lipotropin + beta-melanocyte-stimulating hormone
?
Human beta-lipotropin + H2O
additional information
-
-
-
beta-endorphin(1-31) + beta-endorphin(1-29) + beta-endorphin(1-28) + gamma-lipotropin + beta-melanocyte-stimulating hormone
?
additional information
?
-
-
poorly cleaved: benzyloxycarbonyl-Val-Lys-Lys-Arg 4-methoxy-2-naphthylamide
-
-
?
additional information
?
-
-
the enzyme is highly specific for mono- and dibasic residues of prohormones, overview
-
-
?
additional information
?
-
-
the enzyme is highly specific for mono- and dibasic residues of prohormones
-
-
?