3.4.23.17: Pro-opiomelanocortin converting enzyme
This is an abbreviated version!
For detailed information about Pro-opiomelanocortin converting enzyme, go to the full flat file.
Word Map on EC 3.4.23.17
-
3.4.23.17
-
lobe
-
pituitary
-
beta-endorphin
-
beta-lipotropin
-
residue-specific
-
acth
-
parish
-
pepstatin
-
lys-arg
-
adrenocorticotropin
-
tuteja
-
cooh-terminal
-
glycopeptide
-
endoprotease
-
furin
-
alpha-melanotropin
-
convertase
- 3.4.23.17
- lobe
- pituitary
- beta-endorphin
- beta-lipotropin
-
residue-specific
- acth
-
parish
- pepstatin
- lys-arg
- adrenocorticotropin
-
tuteja
-
cooh-terminal
- glycopeptide
- endoprotease
- furin
-
alpha-melanotropin
-
convertase
Reaction
Cleavage at paired basic residues in certain prohormones, either between them, or on the carboxyl side =
Synonyms
EC 3.4.99.38, More, PCE, POMC converting enzyme, Pro-opiomelanocortin-converting enzyme, Prohormone converting enzyme, Proopiomelanocortin proteinase, Proteinase, proopiomelanocortin, yapsin A
ECTree
3.4.23.17 Pro-opiomelanocortin converting enzymeAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.23.17 - Pro-opiomelanocortin converting enzyme
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
NH2-terminal pro-opiomelanocortin1-77 + H2O
Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
pro-insulin + H2O
insulin chain A + insulin chain B
-
cleavage of a Lys-Arg-/- and Arg-Arg-/- bonds
-
-
?
pro-vasopressin + H2O
neurophysin + glycopeptide
-
cleavage at a monobasic residue
-
-
?
pro-vasopressin + H2O
vasopressin + pro-sequence of vasopressin
-
cleavage of a Lys-Arg-/- bond
-
-
?
NH2-terminal pro-opiomelanocortin1-77 + H2O
Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
O-linked glycosylation at Thr45 greatly inhibits the ability to cleave the Arg49-Lys50 bond
-
-
?
NH2-terminal pro-opiomelanocortin1-77 + H2O
Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
preferential cleavage between Arg49-Lys50
-
-
?
NH2-terminal pro-opiomelanocortin1-77 + H2O
Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
preferential cleavage between Arg49-Lys50
+ gamma-melanotropin, minor product
?
NH2-terminal pro-opiomelanocortin1-77 + H2O
Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
O-linked glycosylation at Thr45 greatly inhibits the ability to cleave the Arg49-Lys50 bond
-
-
?
NH2-terminal pro-opiomelanocortin1-77 + H2O
Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
-
-
?
NH2-terminal pro-opiomelanocortin1-77 + H2O
Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
-
-
?
Pro-insulin + H2O
Insulin A-chain + insulin B-chain
-
-
enzyme cleaves pro-insulin at the Lys-Arg pair to yield the A chain of insulin and at the Arg-Arg pair to yield the B-chain and the A-chain linked to C-chain (A-C) intermediate
?
Pro-opiomelanocortin + H2O
?
-
may function as a pro-opiomelanocortin processing enzyme in the pituitary intermediate lobe
-
-
?
Pro-opiomelanocortin + H2O
?
-
physiological role of PC1 and PC2 as distinct proprotein convertases acting alone or together to produce a set of tissue-specific maturation products in the brain and in the peripheral tissues
-
-
?
Pro-opiomelanocortin + H2O
Adrenocorticotropin + beta-lipotropin
-
-
a 27000 and 22000 Da band detected by anti-N-proopiomelanocortin immunoblots and to 26000 Da, 22000 Da and 14000 DA bands that are immunoreactive with anti-beta-lipotropin
?
Pro-opiomelanocortin + H2O
Adrenocorticotropin + beta-lipotropin
-
cleaves the peptide bonds either between the Lys and Arg or on the carboxyl side of the Arg at Lys-Arg pairs of pro-opiomelanocortin
+ beta-endorphin + MW 16000 NH2-terminal glycopeptide, ACTH of MW 21000-23000, 13000 and 4500
?
Pro-opiomelanocortin + H2O
Adrenocorticotropin + beta-lipotropin
-
-
PC2: beta-endorphin + an N-terminally extended corticotropin containing the joining peptide + either alpha-melanotropin or desacetyl-alpha-melanotropin, PC2 cleaves at the five pairs of basic residues, PC1 cleaves two of them preferentially, PC1: corticotropin + beta-lipotropin
?
Pro-opiomelanocortin + H2O
Adrenocorticotropin + beta-lipotropin
-
-
-
?
Pro-opiomelanocortin + H2O
Adrenocorticotropin + beta-lipotropin
-
-
+ alpha-melanotropin MW 16000 + NH2-terminal glycopeptide + an endorphin-related peptide, ACTH of MW 21000 and 13000
?
Pro-opiomelanocortin + H2O
Adrenocorticotropin + beta-lipotropin
-
-
-
?
Pro-opiomelanocortin + H2O
Adrenocorticotropin + beta-lipotropin
-
-
-
?
pro-opiomelanocortin + H2O
opiomelanocortin + pro-sequence of opiomelanocortin
-
-
-
-
?
pro-opiomelanocortin + H2O
opiomelanocortin + pro-sequence of opiomelanocortin
-
hormone activation
-
-
?
Provasopressin + H2O
Arginine vasopressin-Gly10-Lys11-Arg12
-
cleavage occurs primarily on the carboxyl side of the arginine in the pair of Lys-Arg basic residues separating the vasopressin peptide from the neurophysin moiety in the precursor
major product
?
Provasopressin + H2O
Arginine vasopressin-Gly10-Lys11-Arg12
-
human vasopressin prohormone
major product
?
Small synthetic peptides with paired basic residues + H2O
?
-
-
-
-
?
Small synthetic peptides with paired basic residues + H2O
?
-
-
-
-
?
Human beta-lipotropin + H2O
additional information
-
-
cleavage at two of the three pairs of basic residues of human beta-lipotropin, at Lys37-Lys38 and Lys57-Arg58, but not at Lys86-Lys87, the cleavage at Lys57-Arg58 occurs primarily between these basic residues
at enzyme concentration of 20 ng/0.1 ml: gamma-lipotropin + a beta-melanotropin linked to beta-endorphin intermediate + beta-endorpin, at enzyme concentration of 40 ng/0.1 ml: complete cleavage to yield beta-endorphin + beta-melanotrophin
?
Human beta-lipotropin + H2O
additional information
-
-
-
beta-endorphin(1-31) + beta-endorphin(1-29) + beta-endorphin(1-28) + gamma-lipotropin + beta-melanocyte-stimulating hormone
?
Human beta-lipotropin + H2O
additional information
-
-
-
beta-endorphin(1-31) + beta-endorphin(1-29) + beta-endorphin(1-28) + gamma-lipotropin + beta-melanocyte-stimulating hormone
?
additional information
?
-
-
poorly cleaved: benzyloxycarbonyl-Val-Lys-Lys-Arg 4-methoxy-2-naphthylamide
-
-
?
additional information
?
-
-
the enzyme is highly specific for mono- and dibasic residues of prohormones, overview
-
-
?
additional information
?
-
-
the enzyme is highly specific for mono- and dibasic residues of prohormones
-
-
?
