3.4.23.15: renin
This is an abbreviated version!
For detailed information about renin, go to the full flat file.
Word Map on EC 3.4.23.15
-
3.4.23.15
-
hypertension
-
aldosterone
-
arterial
-
urinary
-
cardiovascular
-
cardiac
-
antihypertensive
-
normotensive
-
gastric
-
glomerular
-
natriuretic
-
hemodynamic
-
systolic
-
diastolic
-
sympathetic
-
ras
-
angiotensin-converting
-
norepinephrine
-
output
-
adrenal
-
blocker
-
prostaglandin
-
ventricular
-
catecholamine
-
diuretic
-
creatinine
-
hg
-
electrolyte
-
placebo
-
vasopressin
-
captopril
-
vasodilator
-
cortisol
-
supine
-
intrarenal
-
renovascular
-
conscious
-
pressor
-
posture
-
acth
-
noradrenaline
-
losartan
-
hypotensive
-
mineralocorticoid
-
vasoconstriction
-
enalapril
-
furosemide
-
anp
-
medicine
-
macula
-
pharmacology
-
aceis
-
diagnostics
- 3.4.23.15
- hypertension
- aldosterone
- arterial
- urinary
- cardiovascular
- cardiac
-
antihypertensive
-
normotensive
- gastric
- glomerular
-
natriuretic
-
hemodynamic
-
systolic
-
diastolic
-
sympathetic
- ras
-
angiotensin-converting
- norepinephrine
- output
- adrenal
-
blocker
- prostaglandin
- ventricular
- catecholamine
-
diuretic
- creatinine
- hg
-
electrolyte
-
placebo
- vasopressin
- captopril
-
vasodilator
- cortisol
-
supine
-
intrarenal
-
renovascular
-
conscious
-
pressor
-
posture
- acth
- noradrenaline
- losartan
-
hypotensive
-
mineralocorticoid
-
vasoconstriction
- enalapril
- furosemide
- anp
- medicine
-
macula
- pharmacology
-
aceis
- diagnostics
Reaction
cleavage of Leu-/- bond in angiotensinogen to generate angiotensin I =
Synonyms
angiotensin-forming enzyme, angiotensinogenase, EC 3.4.4.15, EC 3.4.99.19, prorenin, REN, SVAP, SVAP A1, SVAP B1, SVAP B2, venom aspartic protease
ECTree
3.4.23.15 reninAdvanced search results
results (
results (IC50 Value
IC50 Value on EC 3.4.23.15 - renin
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IC50 VALUE [mM] 
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.0000004
(1S)-7-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00000068
(1S)-7-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)-3-oxa-9-azabicyclo[3.3.1]non-6-ene-6-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000064
(1S)-7-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)-3-thia-9-azabicyclo[3.3.1]non-6-ene-6-carboxamide 3,3-dioxide
Homo sapiens
-
pH and temperature not specified in the publication
0.00000137
(1S)-7-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(3-methoxy-2-methylbenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00000049
(1S)-7-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(3-methoxy-2-methylbenzyl)-3-oxa-9-azabicyclo[3.3.1]non-6-ene-6-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000064
(1S)-7-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(3-methoxy-2-methylbenzyl)-3-thia-9-azabicyclo[3.3.1]non-6-ene-6-carboxamide 3-oxide
Homo sapiens
-
pH and temperature not specified in the publication
0.00000002
(2R)-3-amino-N-cyclopropyl-2-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl]-N-[3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzyl]propanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.000132
(2R)-6-(2,4-diamino-6-ethylpyrimidin-5-yl)-4-(3-methoxypropyl)-2-methyl-2H-1,4-benzoxazin-3(4H)-one
Homo sapiens
-
-
0.1
(2R,4S,5S)-5-amino-N-butyl-4-hydroxy-6-[[(4-methoxyphenyl)sulfonyl](propan-2-yl)amino]-2-methylhexanamide
Homo sapiens
-
IC50 above 0.1 mM, at pH 7.4, temperature not specified in the publication
0.000013
(2R,4S,5S)-5-amino-N-butyl-4-hydroxy-6-[[4-methoxy-3-(3-methoxypropoxy)benzyl](propan-2-yl)amino]-2-methylhexanamide
Homo sapiens
-
at pH 7.4, temperature not specified in the publication
0.0003
(2R,4S,5S)-5-amino-N-butyl-4-hydroxy-6-[[[4-methoxy-3-(3-methoxypropoxy)phenyl]sulfonyl](propan-2-yl)amino]-2-methylhexanamide
Homo sapiens
-
at pH 7.4, temperature not specified in the publication
0.000002 - 0.000004
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(2-methyl-2-morpholin-4-ylpropyl)nonanamide
0.000002 - 0.000007
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(2-morpholin-4-ylethyl)nonanamide
0.000022
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(2-piperidin-1-ylethyl)nonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000008 - 0.000016
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(2-pyridin-2-ylethyl)nonanamide
0.000002 - 0.000012
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(2-thiomorpholin-4-ylethyl)nonanamide
0.000007 - 0.000011
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(3-morpholin-4-ylpropyl)nonanamide
0.000002 - 0.000004
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(4-morpholin-4-yl-4-oxobutyl)nonanamide
0.000003 - 0.000007
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-[3-(1H-tetrazol-5-yl)propyl]nonanamide
0.000002 - 0.000015
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-[3-(3-methyl-1,2,4-oxadiazol-5-yl)propyl]nonanamide
0.000003 - 0.000011
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-[4-(methylamino)-4-oxobutyl]nonanamide
0.000022
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methyl-N-[2-(piperidin-1-yl)ethyl]nonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000008
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methyl-N-[2-(pyridin-2-yl)ethyl]nonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000003
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methyl-N-[3-(1H-tetrazol-5-yl)propyl]nonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000011
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methyl-N-[3-(morpholin-4-yl)propyl]nonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000004 - 0.000002
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-N-(3-methoxypropyl)-2,8-dimethylnonanamide
0.000005 - 0.000049
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-N-[2-(4-methoxypiperidin-1-yl)ethyl]-2,8-dimethylnonanamide
0.000002 - 0.000003
(2R,4S,5S,7S)-5-amino-4-hydroxy-N-(3-hydroxypropyl)-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
0.0000008 - 0.000017
(2R,4S,5S,7S)-5-amino-4-hydroxy-N-(4-hydroxybutyl)-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
0.00001
(2R,4S,5S,7S)-5-amino-4-hydroxy-N-[(4-hydroxypiperidin-1-yl)methyl]-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methylnonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00001 - 0.000052
(2R,4S,5S,7S)-5-amino-4-hydroxy-N-[2-(4-hydroxypiperidin-1-yl)ethyl]-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
0.000004 - 0.000007
(2R,4S,5S,7S)-5-amino-4-hydroxy-N-[3-(1H-imidazol-4-yl)propyl]-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
0.000002 - 0.00001
(2R,4S,5S,7S)-5-amino-4-hydroxy-N-[4-[(2-methoxyethyl)amino]-4-oxobutyl]-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
0.00004 - 0.000092
(2R,4S,5S,7S)-5-amino-7-[3-(2-amino-2-oxoethoxy)-4-methoxybenzyl]-N-butyl-4-hydroxy-2,8-dimethylnonanamide
0.000092
(2R,4S,5S,7S)-5-amino-7-[3-(2-amino-2-oxoethoxy)-4-methoxybenzyl]-N-butyl-4-hydroxy-2-methylnonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00002
(2R,4S,5S,7S)-5-amino-7-[3-(2-amino-2-oxoethoxy)-4-tert-butylbenzyl]-N-butyl-4-hydroxy-2-methylnonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000006 - 0.000015
(2R,4S,5S,7S)-5-amino-7-[3-(benzyloxy)-4-methoxybenzyl]-N-butyl-4-hydroxy-2,8-dimethylnonanamide
0.000016
(2R,4S,5S,7S)-5-amino-N-(2-aminoethyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methylnonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000007 - 0.000013
(2R,4S,5S,7S)-5-amino-N-(3-amino-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
0.000007
(2R,4S,5S,7S)-5-amino-N-(3-amino-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methylnonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000016
(2R,4S,5S,7S)-5-amino-N-(3-aminopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000001 - 0.000003
(2R,4S,5S,7S)-5-amino-N-(3-cyanopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
0.000001 - 0.000011
(2R,4S,5S,7S)-5-amino-N-(4-amino-4-oxobutyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
0.000001
(2R,4S,5S,7S)-5-amino-N-(4-amino-4-oxobutyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methylnonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000002 - 0.000009
(2R,4S,5S,7S)-5-amino-N-(5-amino-5-oxopentyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
0.000002
(2R,4S,5S,7S)-5-amino-N-(5-amino-5-oxopentyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methylnonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000006 - 0.000018
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[3-(3-hydroxypropoxy)-4-methoxybenzyl]-2,8-dimethylnonanamide
0.000006
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[3-(3-hydroxypropoxy)-4-methoxybenzyl]-2-methylnonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000011 - 0.000031
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(2-methoxyethoxy)benzyl]-2,8-dimethylnonanamide
0.000001 - 0.000025
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
0.000001 - 0.000002
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methylnonanamide
0.000002 - 0.00007
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(4-methoxybutoxy)benzyl]-2,8-dimethylnonanamide
0.000002 - 0.000004
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(pentyloxy)benzyl]-2,8-dimethylnonanamide
0.000004
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(pentyloxy)benzyl]-2-methylnonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000005
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(pyridin-4-ylmethoxy)benzyl]-2,8-dimethylnonanamide
0.000021 - 0.00005
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-[(methylsulfonyl)methoxy]benzyl]-2,8-dimethylnonanamide
0.000019 - 0.00014
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-[2-(2-methoxyethoxy)ethoxy]benzyl]-2,8-dimethylnonanamide
0.000019
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-[2-(2-methoxyethoxy)ethoxy]benzyl]-2-methylnonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000042 - 0.00009
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-[2-(methylamino)-2-oxoethoxy]benzyl]-2,8-dimethylnonanamide
0.000042
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-[2-(methylamino)-2-oxoethoxy]benzyl]-2-methylnonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000003 - 0.000004
(2R,4S,5S,7S)-5-amino-N-butyl-7-[3-(2-ethoxyethoxy)-4-methoxybenzyl]-4-hydroxy-2,8-dimethylnonanamide
0.000003 - 0.000009
(2R,4S,5S,7S)-5-amino-N-butyl-7-[3-(3-ethoxypropoxy)-4-methoxybenzyl]-4-hydroxy-2,8-dimethylnonanamide
0.000005
(2R,4S,5S,7S)-5-amino-N-butyl-7-[3-[2,2-dimethyl-3-(methylamino)-3-oxopropoxy]-4-methoxybenzyl]-4-hydroxy-2-methylnonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000002 - 0.000011
(2R,4S,5S,7S)-5-amino-N-[2-(1,1-dioxidothiomorpholin-4-yl)ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
0.000018 - 0.000053
(2R,4S,5S,7S)-5-amino-N-[2-(dimethylamino)ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
0.000018
(2R,4S,5S,7S)-5-amino-N-[2-(dimethylamino)ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methylnonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000002 - 0.000009
(2R,4S,5S,7S)-5-amino-N-[2-(dimethylsulfamoyl)ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
0.000004
(2R,4S,5S,7S)-5-amino-N-[2-(ethylsulfonyl)ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000006 - 0.000025
(2R,4S,5S,7S)-5-amino-N-[2-(tert-butylsulfonyl)ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
0.000002 - 0.000029
(2R,4S,5S,7S)-5-amino-N-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
0.0000003 - 0.000018
(2R,4S,5S,7S)-N-[2-(acetylamino)ethyl]-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
0.000007
(2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-6-[[4-methoxy-3-(3-methoxypropoxy)benzyl](propan-2-yl)amino]-2-(propan-2-yl)hexanamide
Homo sapiens
-
at pH 7.4, temperature not specified in the publication
0.000016
(2S,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-N-[2-methyl-1-(morpholin-4-yl)propan-2-yl]-2-(propan-2-yl)nonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000001
(2S,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-N-[2-methyl-3-(methylamino)-3-oxopropyl]-2-(propan-2-yl)nonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000008
(2S,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-N-[4-(methylamino)-4-oxobutyl]-2-(propan-2-yl)nonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000004
(2S,4S,5S,7S)-5-amino-N-(1-amino-1-oxopropan-2-yl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-(propan-2-yl)nonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000013
(2S,4S,5S,7S)-5-amino-N-(1-amino-2-methyl-1-oxopropan-2-yl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-(propan-2-yl)nonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000002
(2S,4S,5S,7S)-5-amino-N-(1-amino-3-hydroxy-1-oxopropan-2-yl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-(propan-2-yl)nonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000003
(2S,4S,5S,7S)-5-amino-N-(2-amino-2-oxoethyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-(propan-2-yl)nonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000006
(2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-(propan-2-yl)nonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000009
(2S,4S,5S,7S)-5-amino-N-(3-amino-2-methyl-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-(propan-2-yl)nonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000006
(2S,4S,5S,7S)-5-amino-N-(4-amino-4-oxobutan-2-yl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-(propan-2-yl)nonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000007
(2S,4S,5S,7S)-5-amino-N-(4-amino-4-oxobutyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-(propan-2-yl)nonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000004
(2S,4S,5S,7S)-5-amino-N-[2,2-dimethyl-3-(methylamino)-3-oxopropyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-(propan-2-yl)nonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000007
(3R)-3-[(1S)-1-(2-chlorophenyl)-1-hydroxy-5-methoxypentyl]-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.00000013
(3R)-3-[(1S)-1-(3-bromophenyl)-1-hydroxy-5-methoxypentyl]-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.0000001
(3R)-3-[(1S)-1-(3-chloro-2-fluorophenyl)-1-hydroxy-5-methoxypentyl]-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.0000009
(3R)-3-[(1S)-1-(3-chloro-5-fluorophenyl)-1-hydroxy-5-methoxypentyl]-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000021
(3R)-3-[(1S)-1-(3-chlorophenyl)-1,5-dihydroxypentyl]-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.00000047
(3R)-3-[(1S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxypentyl]-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000046
(3R)-3-[(1S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxypentyl]-N-[(2S)-1-cyclohexyl-3-[(2,2,2-trifluoroethyl)amino]propan-2-yl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000037
(3R)-3-[(1S)-1-(3-cyanophenyl)-1-hydroxy-5-methoxypentyl]-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000039
(3R)-3-[(R)-(3-chloro-2-fluorophenyl)(3-methoxypropoxy)methyl]-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000004
(3R)-3-[(R)-(3-chlorophenyl)(3-ethoxypropoxy)methyl]-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000764
(3R)-3-[(R)-(3-chlorophenyl)(3-hydroxypropoxy)methyl]-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000021
(3R)-N-[(2S)-1-amino-3-cyclohexylpropan-2-yl]-3-[(1S)-1-hydroxy-5-methoxy-1-phenylpentyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000038
(3R)-N-[(2S)-1-amino-3-cyclohexylpropan-2-yl]-3-[(1S)-5-ethoxy-1-hydroxy-1-phenylpentyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.0000055
(3R)-N-[(2S)-1-amino-3-cyclohexylpropan-2-yl]-3-[(R)-(3-chlorophenyl)(3-ethoxypropoxy)methyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000055
(3R)-N-[(2S)-1-amino-3-cyclohexylpropan-2-yl]-3-[(R)-(3-ethoxypropoxy)(phenyl)methyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000308
(3R)-N-[(2S)-1-amino-3-cyclohexylpropan-2-yl]-3-[(R)-(3-methoxypropoxy)(phenyl)methyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.00000014
(3R)-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]-3-[(1S)-1-(2,3-difluorophenyl)-1-hydroxy-5-methoxypentyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.0000035
(3R)-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]-3-[(1S)-1-(2-fluoro-5-methylphenyl)-1-hydroxy-5-methoxypentyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000004
(3R)-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]-3-[(1S)-1-(2-fluorophenyl)-1-hydroxy-5-methoxypentyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000009
(3R)-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]-3-[(1S)-1-(3-ethylphenyl)-1-hydroxy-5-methoxypentyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000003
(3R)-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]-3-[(1S)-1-(3-fluorophenyl)-1-hydroxy-5-methoxypentyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000013
(3R)-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]-3-[(1S)-1-hydroxy-5-methoxy-1-(3-methoxyphenyl)pentyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.0000025
(3R)-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]-3-[(1S)-1-hydroxy-5-methoxy-1-(3-methylphenyl)pentyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000007
(3R)-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]-3-[(1S)-1-hydroxy-5-methoxy-1-phenylpentyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000069
(3R)-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]-3-[(1S)-1-hydroxy-5-methoxy-1-[3-(trifluoromethoxy)phenyl]pentyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000007
(3R)-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]-3-[(1S)-1-hydroxy-5-methoxy-1-[3-(trifluoromethyl)phenyl]pentyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000016
(3R)-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]-3-[(1S)-5-ethoxy-1-hydroxy-1-phenylpentyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000125
(3R)-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]-3-[(R)-(2,3-dichlorophenyl)(3-ethoxypropoxy)methyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000609
(3R)-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]-3-[(R)-(2,3-dichlorophenyl)(3-methoxypropoxy)methyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000011
(3R)-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]-3-[(R)-(3-ethoxypropoxy)(3-fluorophenyl)methyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.00004
(3R)-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]-3-[(R)-(3-ethoxypropoxy)(phenyl)methyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000058
(3R)-N-[(2S)-1-cyclohexyl-3-(methylamino)propan-2-yl]-3-[(R)-(3-fluorophenyl)(3-methoxypropoxy)methyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.000006
(3R)-N-[(2S)-1-[(chloromethyl)amino]-3-cyclohexylpropan-2-yl]-3-[(1S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxypentyl]piperidine-1-carboxamide
Homo sapiens
in 50 mM BES buffer, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, at 25°C
0.00000055
(5R)-3-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)-8-azabicyclo[3.2.1]oct-2-ene-2-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000011
(5R)-3-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)-9-azabicyclo[3.3.1]non-2-ene-2-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00000074
(5R)-3-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(3-methoxy-2-methylbenzyl)-8-azabicyclo[3.2.1]oct-2-ene-2-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00000092
(5R)-3-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(3-methoxy-2-methylbenzyl)-9-azabicyclo[3.3.1]non-2-ene-2-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0194
2'-O-beta-D-glucopyranosyl momordin Ic
Homo sapiens
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C
0.0384
2'-O-beta-D-glucopyranosyl momordin IIc
Homo sapiens
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C
0.0000019
2-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]benzyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)-3-(methylamino)propanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.00000055 - 0.00056
3-(5-amino-5-oxopentanoyl)-7-[4-[3-(2-bromo-5-fluorophenoxy)propyl]phenyl]-N-(2-chlorobenzyl)-N-cyclopropyl-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide
0.00026
3-(benzylamino)-2-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]benzyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)propanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.00021
3-amino-2-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]benzyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)-2-methylpropanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.00000079
3-amino-2-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]benzyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)propanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.0000004
3-amino-N-cyclopropyl-N-(2,3-dichlorobenzyl)-2-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl]propanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.00000026
3-amino-N-cyclopropyl-N-[2,3-dichloro-5-(3-methoxypropyl)benzyl]-2-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl]propanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.00000027
3-amino-N-[2-chloro-5-(2-cyanoethyl)benzyl]-N-cyclopropyl-2-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl]propanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.00000011
3-amino-N-[2-chloro-5-(3-cyanopropyl)benzyl]-N-cyclopropyl-2-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl]propanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.00000009
3-amino-N-[2-chloro-5-(3-hydroxypropyl)benzyl]-N-cyclopropyl-2-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl]propanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.00000021
3-amino-N-[2-chloro-5-(4-methoxybutoxy)benzyl]-N-cyclopropyl-2-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl]propanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.00000019
3-amino-N-[2-chloro-5-(4-methoxybutyl)benzyl]-N-cyclopropyl-2-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl]propanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.00000026
3-amino-N-[2-chloro-5-(6-methoxyhexyl)benzyl]-N-cyclopropyl-2-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl]propanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.0000015
3-amino-N-[2-chloro-5-[3-(dimethylamino)propyl]benzyl]-N-cyclopropyl-2-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl]propanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.0000003
3-amino-N-[[5-chloro-2-(3-methoxypropyl)-1-oxidopyridin-4-yl]methyl]-N-cyclopropyl-2-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl]propanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.00000019
3-amino-N-[[5-chloro-2-(3-methoxypropyl)pyridin-4-yl]methyl]-N-cyclopropyl-2-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl]propanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.000003 - 0.000013
4-([(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanoyl]amino)butanoic acid
0.000006 - 0.000009
4-([(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanoyl]amino)butyl acetate
0.000003
4-([(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methylnonanoyl]amino)butanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000006
4-([(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methylnonanoyl]amino)butyl acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.000336
4-amino-N-[2-[2-([2-amino-6-ethyl-5-[4-(3-methoxypropyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl]pyrimidin-4-yl]amino)ethyl]phenyl]-3-methoxybenzamide
Homo sapiens
-
-
0.00033
4-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-5,5-difluoro-N-(3-methoxy-2-methylbenzyl)-1,2,5,6-tetrahydropyridine-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000012
4-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)-1,2,5,6-tetrahydropyridine-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0008
4-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)-5,5-difluoro-1,2,5,6-tetrahydropyridine-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000031
4-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)-5,5-dimethyl-1,2,5,6-tetrahydropyridine-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000002
4-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(3-methoxy-2-methylbenzyl)-1,2,5,6-tetrahydropyridine-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00017
4-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(3-methoxy-2-methylbenzyl)-5,5-dimethyl-1,2,5,6-tetrahydropyridine-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00065
5-amino-3-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)pentanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.00656
5-[4-[(3,5-difluorobenzyl)amino]phenyl]-6-ethylpyrimidine-2,4-diamine
Homo sapiens
-
-
0.0000071
6-(2,4-diamino-6-ethylpyrimidin-5-yl)-2-(3,5-difluorophenyl)-4-(3-methoxypropyl)-2-methyl-2H-1,4-benzoxazin-3(4H)-one
Homo sapiens
-
-
0.000095
6-(2,4-diamino-6-ethylpyrimidin-5-yl)-2-(3,5-difluorophenyl)-4-(3-methoxypropyl)-2H-1,4-benzoxazin-3(4H)-one
Homo sapiens
-
-
0.000691
6-ethyl-5-[1-(3-methoxypropyl)-1,2,3,4-tetrahydroquinolin-7-yl]pyrimidine-2,4-diamine
Homo sapiens
-
-
0.000058
6-ethyl-5-[1-(3-methoxypropyl)-2-phenyl-1,2,3,4-tetrahydroquinolin-7-yl]pyrimidine-2,4-diamine
Homo sapiens
-
-
0.000173
6-ethyl-5-[9-(3-methoxypropyl)-9H-carbazol-2-yl]pyrimidine-2,4-diamine
Homo sapiens
-
-
0.0000004 - 0.00036
7-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide
0.000034
8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)-5-azaspiro[2.5]oct-7-ene-7-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00021
8-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(3-methoxy-2-methylbenzyl)-5-azaspiro[2.5]oct-7-ene-7-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0774
chikusetsusaponin IV
Homo sapiens
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C
0.000004 - 0.000013
ethyl N-[(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanoyl]-beta-alaninate
0.000004
ethyl N-[(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methylnonanoyl]-beta-alaninate
Homo sapiens
-
pH and temperature not specified in the publication
0.0571
glycyrrhizin
Homo sapiens
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C
2.3
L-Ile-L-Trp
Homo sapiens
-
recombinant enzyme, in 50 mM Tris-HCl buffer containing 100 mM NaCl (pH 8.0), at 37°C
0.000003
methyl (5-[[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy-5-methyl-6-oxohexyl](propan-2-yl)carbamoyl]-2-methoxybenzyl)carbamate
Homo sapiens
-
at pH 7.4, temperature not specified in the publication
0.000001 - 0.000003
methyl 4-([(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanoyl]amino)butanoate
0.0001
methyl [2-(5-[[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy-5-methyl-6-oxohexyl](propan-2-yl)carbamoyl]-2-methoxyphenyl)ethyl]carbamate
Homo sapiens
-
at pH 7.4, temperature not specified in the publication
0.00005
methyl [5-[(2S,4S,5S,7R)-4-amino-8-(butylamino)-2-ethyl-5-hydroxy-7-methyl-8-oxooctyl]-2-methoxyphenoxy]methanesulfinate
Homo sapiens
-
pH and temperature not specified in the publication
0.000006
methyl [5-[(2S,4S,5S,7R)-4-amino-8-(butylamino)-2-ethyl-5-hydroxy-7-methyl-8-oxooctyl]-2-tert-butylphenoxy]acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.000013
methyl [5-[(2S,4S,5S,7R)-4-amino-8-(butylamino)-2-ethyl-5-hydroxy-7-methyl-8-oxooctyl]-2-tert-butylphenoxy]methanesulfinate
Homo sapiens
-
pH and temperature not specified in the publication
0.000004 - 0.00019
methyl [5-[(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydroxy-7-methyl-2-(1-methylethyl)-8-oxooctyl]-2-methoxyphenoxy]acetate
0.0259
momordin Ic
Homo sapiens
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C
0.0468
momordin IIc
Homo sapiens
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C
0.0422
monoglucuronyl glycyrrhetic acid
Homo sapiens
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C
0.0000029
N-(5-[[acetyl(methyl)amino]methyl]-2-chlorobenzyl)-3-amino-N-cyclopropyl-2-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl]propanamide
Homo sapiens
-
at pH 7.4 and 37°C
0.0000002 - 0.00019
N-cyclopropyl-7-[4-[3-(2,6-dichloro-4-methylphenoxy)propyl]phenyl]-N-(2,3-dimethylbenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide
0.000012 - 0.000023
N-[(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanoyl]-beta-alanine
0.000012
N-[(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methylnonanoyl]-beta-alanine
Homo sapiens
-
pH and temperature not specified in the publication
0.000008
N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy-5-methyl-6-oxohexyl]-3-(3-methoxypropoxy)-4-methyl-N-(propan-2-yl)benzamide
Homo sapiens
-
at pH 7.4, temperature not specified in the publication
0.000008
N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy-5-methyl-6-oxohexyl]-4-bromo-3-(3-methoxypropoxy)-N-(propan-2-yl)benzamide
Homo sapiens
-
at pH 7.4, temperature not specified in the publication
0.000002
N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy-5-methyl-6-oxohexyl]-4-ethyl-3-(3-methoxypropoxy)-N-(propan-2-yl)benzamide
Homo sapiens
-
at pH 7.4, temperature not specified in the publication
0.000006
N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy-5-methyl-6-oxohexyl]-4-ethynyl-3-(3-methoxypropoxy)-N-(propan-2-yl)benzamide
Homo sapiens
-
at pH 7.4, temperature not specified in the publication
0.000002
N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy-5-methyl-6-oxohexyl]-4-methoxy-3-(3-methoxypropoxy)-N-(propan-2-yl)benzamide
Homo sapiens
-
at pH 7.4, temperature not specified in the publication
0.000001
N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy-5-methyl-6-oxohexyl]-4-methoxy-3-(4-methoxybutyl)-N-(propan-2-yl)benzamide
Homo sapiens
-
at pH 7.4, temperature not specified in the publication
0.000001
N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy-5-methyl-6-oxohexyl]-4-methoxy-3-[(1E)-4-methoxybut-1-en-1-yl]-N-(propan-2-yl)benzamide
Homo sapiens
-
at pH 7.4, temperature not specified in the publication
0.000001
N-[(2S,3S,5S)-2-amino-5-(butylcarbamoyl)-3-hydroxy-6-methylheptyl]-4-ethyl-3-(3-methoxypropoxy)-N-(propan-2-yl)benzamide
Homo sapiens
-
at pH 7.4, temperature not specified in the publication
0.000027
N-[2-([2-amino-6-ethyl-5-[4-(3-methoxypropyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl]pyrimidin-4-yl]amino)ethyl]naphthalene-2-sulfonamide
Homo sapiens
-
-
0.000222
N-[2-[6-(2,4-diamino-6-ethylpyrimidin-5-yl)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]ethyl]acetamide
Homo sapiens
-
-
0.0336
soyasaponin I
Homo sapiens
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C
0.0303
soyasaponin II
Homo sapiens
-
in 50 mM sodium phosphate, pH 6.5, 0.1 M NaCl, 0.02% (v/v) Tween 20, at 37°C
-
0.044
tetradecanoyl acetal sodium sulfite
Homo sapiens
-
complex formation with the enzyme, mixed inhibition type, IC50: 0.044 mM
0.000002
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(2-methyl-2-morpholin-4-ylpropyl)nonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000004
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(2-methyl-2-morpholin-4-ylpropyl)nonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000002
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(2-morpholin-4-ylethyl)nonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000007
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(2-morpholin-4-ylethyl)nonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000008
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(2-pyridin-2-ylethyl)nonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000016
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(2-pyridin-2-ylethyl)nonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000002
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(2-thiomorpholin-4-ylethyl)nonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000012
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(2-thiomorpholin-4-ylethyl)nonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000007
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(3-morpholin-4-ylpropyl)nonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000011
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(3-morpholin-4-ylpropyl)nonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000002
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(4-morpholin-4-yl-4-oxobutyl)nonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000004
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-(4-morpholin-4-yl-4-oxobutyl)nonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000003
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-[3-(1H-tetrazol-5-yl)propyl]nonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000007
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-[3-(1H-tetrazol-5-yl)propyl]nonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000002
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-[3-(3-methyl-1,2,4-oxadiazol-5-yl)propyl]nonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000015
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-[3-(3-methyl-1,2,4-oxadiazol-5-yl)propyl]nonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000003
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-[4-(methylamino)-4-oxobutyl]nonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000011
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethyl-N-[4-(methylamino)-4-oxobutyl]nonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.0000004
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-N-(3-methoxypropyl)-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000002
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-N-(3-methoxypropyl)-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000005
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-N-[2-(4-methoxypiperidin-1-yl)ethyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000049
(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-N-[2-(4-methoxypiperidin-1-yl)ethyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000002
(2R,4S,5S,7S)-5-amino-4-hydroxy-N-(3-hydroxypropyl)-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000003
(2R,4S,5S,7S)-5-amino-4-hydroxy-N-(3-hydroxypropyl)-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.0000008
(2R,4S,5S,7S)-5-amino-4-hydroxy-N-(4-hydroxybutyl)-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000017
(2R,4S,5S,7S)-5-amino-4-hydroxy-N-(4-hydroxybutyl)-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.00001
(2R,4S,5S,7S)-5-amino-4-hydroxy-N-[2-(4-hydroxypiperidin-1-yl)ethyl]-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000052
(2R,4S,5S,7S)-5-amino-4-hydroxy-N-[2-(4-hydroxypiperidin-1-yl)ethyl]-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000004
(2R,4S,5S,7S)-5-amino-4-hydroxy-N-[3-(1H-imidazol-4-yl)propyl]-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000007
(2R,4S,5S,7S)-5-amino-4-hydroxy-N-[3-(1H-imidazol-4-yl)propyl]-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000002
(2R,4S,5S,7S)-5-amino-4-hydroxy-N-[4-[(2-methoxyethyl)amino]-4-oxobutyl]-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.00001
(2R,4S,5S,7S)-5-amino-4-hydroxy-N-[4-[(2-methoxyethyl)amino]-4-oxobutyl]-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.00004
(2R,4S,5S,7S)-5-amino-7-[3-(2-amino-2-oxoethoxy)-4-methoxybenzyl]-N-butyl-4-hydroxy-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000092
(2R,4S,5S,7S)-5-amino-7-[3-(2-amino-2-oxoethoxy)-4-methoxybenzyl]-N-butyl-4-hydroxy-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.0000006
(2R,4S,5S,7S)-5-amino-7-[3-(benzyloxy)-4-methoxybenzyl]-N-butyl-4-hydroxy-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000015
(2R,4S,5S,7S)-5-amino-7-[3-(benzyloxy)-4-methoxybenzyl]-N-butyl-4-hydroxy-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000007
(2R,4S,5S,7S)-5-amino-N-(3-amino-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000013
(2R,4S,5S,7S)-5-amino-N-(3-amino-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000001
(2R,4S,5S,7S)-5-amino-N-(3-cyanopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000003
(2R,4S,5S,7S)-5-amino-N-(3-cyanopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000001
(2R,4S,5S,7S)-5-amino-N-(4-amino-4-oxobutyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000011
(2R,4S,5S,7S)-5-amino-N-(4-amino-4-oxobutyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000002
(2R,4S,5S,7S)-5-amino-N-(5-amino-5-oxopentyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000009
(2R,4S,5S,7S)-5-amino-N-(5-amino-5-oxopentyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000006
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[3-(3-hydroxypropoxy)-4-methoxybenzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000018
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[3-(3-hydroxypropoxy)-4-methoxybenzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000011
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(2-methoxyethoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000031
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(2-methoxyethoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000001
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000001
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
at pH 7.4, temperature not specified in the publication
0.000025
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000001
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methylnonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000002
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2-methylnonanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000002
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(4-methoxybutoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.00007
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(4-methoxybutoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000002
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(pentyloxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000004
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(pentyloxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000005
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(pyridin-4-ylmethoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000005
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-(pyridin-4-ylmethoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000021
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-[(methylsulfonyl)methoxy]benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.00005
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-[(methylsulfonyl)methoxy]benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000019
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-[2-(2-methoxyethoxy)ethoxy]benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.00014
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-[2-(2-methoxyethoxy)ethoxy]benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000042
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-[2-(methylamino)-2-oxoethoxy]benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.00009
(2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-[4-methoxy-3-[2-(methylamino)-2-oxoethoxy]benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000003
(2R,4S,5S,7S)-5-amino-N-butyl-7-[3-(2-ethoxyethoxy)-4-methoxybenzyl]-4-hydroxy-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000004
(2R,4S,5S,7S)-5-amino-N-butyl-7-[3-(2-ethoxyethoxy)-4-methoxybenzyl]-4-hydroxy-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000003
(2R,4S,5S,7S)-5-amino-N-butyl-7-[3-(3-ethoxypropoxy)-4-methoxybenzyl]-4-hydroxy-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000009
(2R,4S,5S,7S)-5-amino-N-butyl-7-[3-(3-ethoxypropoxy)-4-methoxybenzyl]-4-hydroxy-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000002
(2R,4S,5S,7S)-5-amino-N-[2-(1,1-dioxidothiomorpholin-4-yl)ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000011
(2R,4S,5S,7S)-5-amino-N-[2-(1,1-dioxidothiomorpholin-4-yl)ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000018
(2R,4S,5S,7S)-5-amino-N-[2-(dimethylamino)ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000053
(2R,4S,5S,7S)-5-amino-N-[2-(dimethylamino)ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000002
(2R,4S,5S,7S)-5-amino-N-[2-(dimethylsulfamoyl)ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000009
(2R,4S,5S,7S)-5-amino-N-[2-(dimethylsulfamoyl)ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000006
(2R,4S,5S,7S)-5-amino-N-[2-(tert-butylsulfonyl)ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000025
(2R,4S,5S,7S)-5-amino-N-[2-(tert-butylsulfonyl)ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000002
(2R,4S,5S,7S)-5-amino-N-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000029
(2R,4S,5S,7S)-5-amino-N-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethyl]-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.0000003
(2R,4S,5S,7S)-N-[2-(acetylamino)ethyl]-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000018
(2R,4S,5S,7S)-N-[2-(acetylamino)ethyl]-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanamide
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.00000055
3-(5-amino-5-oxopentanoyl)-7-[4-[3-(2-bromo-5-fluorophenoxy)propyl]phenyl]-N-(2-chlorobenzyl)-N-cyclopropyl-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide
Homo sapiens
in buffer
0.00056
3-(5-amino-5-oxopentanoyl)-7-[4-[3-(2-bromo-5-fluorophenoxy)propyl]phenyl]-N-(2-chlorobenzyl)-N-cyclopropyl-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide
Homo sapiens
in buffer
0.000003
4-([(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanoyl]amino)butanoic acid
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000013
4-([(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanoyl]amino)butanoic acid
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000006
4-([(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanoyl]amino)butyl acetate
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000009
4-([(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanoyl]amino)butyl acetate
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.0000004
7-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide
Homo sapiens
in buffer
0.00036
7-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-(2,3-dichlorobenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide
Homo sapiens
in buffer
0.0000005
aliskiren
Homo sapiens
in 50 mM BES, 150 mM NaCl, 0.25 mg/ml bovine serum albumin, pH 7.0, temperature not specified in the publication
0.000004
ethyl N-[(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanoyl]-beta-alaninate
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000013
ethyl N-[(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanoyl]-beta-alaninate
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000001
methyl 4-([(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanoyl]amino)butanoate
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000003
methyl 4-([(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanoyl]amino)butanoate
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.000004
methyl [5-[(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydroxy-7-methyl-2-(1-methylethyl)-8-oxooctyl]-2-methoxyphenoxy]acetate
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.00019
methyl [5-[(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydroxy-7-methyl-2-(1-methylethyl)-8-oxooctyl]-2-methoxyphenoxy]acetate
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
0.0000002
N-cyclopropyl-7-[4-[3-(2,6-dichloro-4-methylphenoxy)propyl]phenyl]-N-(2,3-dimethylbenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide
Homo sapiens
in buffer
0.00019
N-cyclopropyl-7-[4-[3-(2,6-dichloro-4-methylphenoxy)propyl]phenyl]-N-(2,3-dimethylbenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide
Homo sapiens
in buffer
0.000012
N-[(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanoyl]-beta-alanine
Homo sapiens
-
pH 7.2, 37°C, purified enzyme
0.000023
N-[(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-2,8-dimethylnonanoyl]-beta-alanine
Callithrix sp.
-
pH 7.2, 37°C, plasma enzyme assay
additional information
aliskiren
Homo sapiens
-
estimated concentration of aliskiren necessary for producing 50% inhibition of plasma renin activity is 0.66 ng/ml
additional information
chitooligosaccharide
Homo sapiens
-
chitololigosaccharides from 90% deacetylated chitosan and with molecular weight of 1000-5000 Da exhibit an IC50 value of 0.51 mg/ml. Chitooligosaccharides from 90% deacetylated chitosan and with molecular weight below 1000 Da show an IC50 value of 0.59 mg/ml
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