3.4.23.1: pepsin A
This is an abbreviated version!
For detailed information about pepsin A, go to the full flat file.
Word Map on EC 3.4.23.1
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3.4.23.1
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gastric
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mucosa
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porcine
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ulcer
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pylori
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helicobacter
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stomach
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gastritis
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proteinases
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peptic
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juice
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chymosin
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atrophic
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zymogen
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pepstatin
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reflux
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isozymogens
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gastricsin
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endoscopy
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omeprazole
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progastricsins
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prosegment
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fundic
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pentagastrin
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prochymosins
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milk-clotting
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medicine
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synthesis
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abomasum
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hypergastrinaemia
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nutrition
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pylori-positive
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analysis
-
food industry
- 3.4.23.1
- gastric
- mucosa
- porcine
- ulcer
- pylori
- helicobacter
- stomach
- gastritis
- proteinases
-
peptic
- juice
- chymosin
-
atrophic
- zymogen
- pepstatin
- reflux
-
isozymogens
- gastricsin
-
endoscopy
- omeprazole
- progastricsins
- prosegment
-
fundic
- pentagastrin
- prochymosins
-
milk-clotting
- medicine
- synthesis
- abomasum
-
hypergastrinaemia
- nutrition
-
pylori-positive
- analysis
- food industry
Reaction
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-/-Val, Gln4-/-His, Glu13-/-Ala, Ala14-/-Leu, Leu15-/-Tyr, Tyr16-/-Leu, Gly23-/-Phe, Phe24-/-Phe and Phe25-/-Tyr bonds in the B chain of insulin =
Synonyms
Aspartic proteinase, EC 3.4.4.1, elixir lactate of pepsin, fundus-pepsin, lactated pepsin, lactated pepsin elixir, P I, P-Ia, P-Ib, P-II, P-III, pep/PAG-L, pepsin, pepsin 1, pepsin A, pepsin A1, pepsin A2, pepsin D, pepsin fortior, Pepsin I/II, pepsin R, pepsinogen A, pepsinogen/PAG-Like, pepsins A1, pepsins A2, PG1, PG1-1, PG2, PG2-2, shewasin A, shewasin D
ECTree
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pH Range
pH Range on EC 3.4.23.1 - pepsin A
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0.5 - 3.5
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N,N-dimethylhemoglobin, pH 0.5: about 30% of maximum activity, pH 3.5: about 15% of maximum activity
0.5 - 5
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N,N-dimethylcasein, pH 0.5: about 35% of maximum activity, pH 5.0: about 20% of maximum activity
1 - 3.5
1 - 4
pH 1.0: about 70% of maximal activity, pH 4.0: about 50% of maximal activity
1 - 6
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trout pepsins exhibit the highest enzyme activity at pH 3.0 (isoform P-I) and 2.5 (isoforms P-II and P-III); P-I shows a broad optimum in the pH range from 1.5 to 4.0, while the optima for P-II and III are restricted to the pH range from 2.0 to 3.0.at pH 4.0. Isoform P-I retains 94% activity, while isoforms P-II 72 and P-III have 65% activity. All three isoforms show residual activity of about 20% at pH 6.0
1.5 - 4
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pH 1.5: about 75% of maximum activity, pH 4.0: about 30% of maximum activity
1.5 - 4.5
2 - 5
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with serum albumin as a substrate, the enzyme retains 70% of its activity at pH 4.0 and almost 40% at pH 5.0
2.5 - 4
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pH 2.5: about 55% of maximal activity, pH 4.0: about 55% of maximal activity
3 - 5
maximum activity towards this substrate at pH values between pH 3.5 and 4.0, with a drastic decrease in activity of 50% and 70% at pH values 3.0 and 5.0, respectively
3.5 - 5
50% activity is retained at pH 5.0 At pH 6.0, the enzyme shows no activity
additional information
1 - 3.5
pH 1.0: about 85% of maximal activity, pH 3.5: about 40% of maximal activity
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pH 1.5: about 90% of maximum activity, pH 4.5: about 35% of maximum activity
1.5 - 4.5
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pH 1.5: about 90% of maximum activity, pH 4.5: about 35% of maximum activity