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3.4.23.1: pepsin A

This is an abbreviated version!
For detailed information about pepsin A, go to the full flat file.

Word Map on EC 3.4.23.1

Reaction

Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-/-Val, Gln4-/-His, Glu13-/-Ala, Ala14-/-Leu, Leu15-/-Tyr, Tyr16-/-Leu, Gly23-/-Phe, Phe24-/-Phe and Phe25-/-Tyr bonds in the B chain of insulin =

Synonyms

Aspartic proteinase, EC 3.4.4.1, elixir lactate of pepsin, fundus-pepsin, lactated pepsin, lactated pepsin elixir, P I, P-Ia, P-Ib, P-II, P-III, pep/PAG-L, pepsin, pepsin 1, pepsin A, pepsin A1, pepsin A2, pepsin D, pepsin fortior, Pepsin I/II, pepsin R, pepsinogen A, pepsinogen/PAG-Like, pepsins A1, pepsins A2, PG1, PG1-1, PG2, PG2-2, shewasin A, shewasin D

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.1 pepsin A

Temperature Range

Temperature Range on EC 3.4.23.1 - pepsin A

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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10 - 40
maximum enzyme activity is detected between 30°C and 37°C. Above this temperature the activity abruptly decreases, with no detectable activity remaining at 50°C. At lower temperatures the activity decreases gradually, with the enzyme retaining 30% activity at 10°C
20 - 55
-
20°C: about 40% of maximal activity, 55°C: about 60% of maximal activity
25 - 50
25°C: about 70% of maximal activity, 50°C: about 90% of maximal activity
25 - 60
25°C: about 50% of maximal activity, 60°C: about 10% of maximal activity
30 - 40
-
temperature optimum for selective digestion of collagen telopeptides
30 - 80
-
-