3.4.23.1: pepsin A
This is an abbreviated version!
For detailed information about pepsin A, go to the full flat file.
Word Map on EC 3.4.23.1
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3.4.23.1
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gastric
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mucosa
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porcine
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ulcer
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pylori
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helicobacter
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stomach
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gastritis
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proteinases
-
peptic
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juice
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chymosin
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atrophic
-
zymogen
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pepstatin
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reflux
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isozymogens
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gastricsin
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endoscopy
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omeprazole
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progastricsins
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prosegment
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fundic
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pentagastrin
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prochymosins
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milk-clotting
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medicine
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synthesis
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abomasum
-
hypergastrinaemia
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nutrition
-
pylori-positive
-
analysis
-
food industry
- 3.4.23.1
- gastric
- mucosa
- porcine
- ulcer
- pylori
- helicobacter
- stomach
- gastritis
- proteinases
-
peptic
- juice
- chymosin
-
atrophic
- zymogen
- pepstatin
- reflux
-
isozymogens
- gastricsin
-
endoscopy
- omeprazole
- progastricsins
- prosegment
-
fundic
- pentagastrin
- prochymosins
-
milk-clotting
- medicine
- synthesis
- abomasum
-
hypergastrinaemia
- nutrition
-
pylori-positive
- analysis
- food industry
Reaction
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-/-Val, Gln4-/-His, Glu13-/-Ala, Ala14-/-Leu, Leu15-/-Tyr, Tyr16-/-Leu, Gly23-/-Phe, Phe24-/-Phe and Phe25-/-Tyr bonds in the B chain of insulin =
Synonyms
Aspartic proteinase, EC 3.4.4.1, elixir lactate of pepsin, fundus-pepsin, lactated pepsin, lactated pepsin elixir, P I, P-Ia, P-Ib, P-II, P-III, pep/PAG-L, pepsin, pepsin 1, pepsin A, pepsin A1, pepsin A2, pepsin D, pepsin fortior, Pepsin I/II, pepsin R, pepsinogen A, pepsinogen/PAG-Like, pepsins A1, pepsins A2, PG1, PG1-1, PG2, PG2-2, shewasin A, shewasin D
ECTree
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Source Tissue
Source Tissue on EC 3.4.23.1 - pepsin A
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additional information
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secretions from the trachea, lung, nose, sinus, middle ear, and exhaled breath condensate
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processing of sonic hedgehog in the normal stomach is hormonally regulated, acid-dependent, and mediated by the aspartic protease pepsin A. Parietal cell atrophy, a known preneoplastic lesion, correlates with loss of sonic hedgehog processing