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3.4.22.40: bleomycin hydrolase

This is an abbreviated version!
For detailed information about bleomycin hydrolase, go to the full flat file.

Word Map on EC 3.4.22.40

Reaction

Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred =

Synonyms

aminopeptidase C, aminopeptidase H, ApsC, BANA-hydrolase, BH, BH protein, Bleomycin hydrolase, BLH, Blh1p, BLM hydrolase, Blmh, BLMH protein, BMH, citrulline aminopeptidase, Gal6p, Hcy-thiolactonase, homocysteine thiolactonase, HTLase, hydrolase H, More, PEPC, yBLH, yeast cysteine protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.40 bleomycin hydrolase

Turnover Number

Turnover Number on EC 3.4.22.40 - bleomycin hydrolase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.9
6'-deoxy bleomycin A2
pH 7.5, 30°C
15
6'-deoxy bleomycin Z
pH 7.5, 30°C
2.5
6'-deoxy tallysomycin H1
pH 7.5, 30°C
4
bleomycin A2
pH 7.5, 30°C
11
bleomycin B2
pH 7.5, 30°C
9.8
bleomycin Z
pH 7.5, 30°C
2.4
tallysomycin H1
pH 7.5, 30°C