3.4.22.40: bleomycin hydrolase

This is an abbreviated version!
For detailed information about bleomycin hydrolase, go to the full flat file.

Word Map on EC 3.4.22.40

Reaction

Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred =

Synonyms

More, PEPC, aminopeptidase C, hydrolase H, BANA-hydrolase, Blh1p, Gal6p, aminopeptidase H, Bleomycin hydrolase, BLM hydrolase, BMH, ApsC, BH, yeast cysteine protease, yBLH, homocysteine thiolactonase, Hcy-thiolactonase, HTLase, BLH, BH protein, BLMH protein, citrulline aminopeptidase, Blmh

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.40 bleomycin hydrolase

Source Tissue

Source Tissue on EC 3.4.22.40 - bleomycin hydrolase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
high expression level
Manually annotated by BRENDA team
histological examination, increase in GFAP-positively stained astroglia observed in the brains of aged null mice compared with wild-type controls
Manually annotated by BRENDA team
MEFs, bleomycin hydrolase-deficient cells from mice
Manually annotated by BRENDA team
extracts, bleomycin hydrolase detection by Western blot
Manually annotated by BRENDA team
testicular germ-cell cancer, response to chemotherapy dependent on gene polymorphism of bleomycin hydrolase analyzed
Manually annotated by BRENDA team
detected by immunohistochemistry
Manually annotated by BRENDA team
of 6-week-old rats, tissue amounts of bleomycin hydrolase determined, relative high amounts detected
Manually annotated by BRENDA team
-
high expression level
Manually annotated by BRENDA team
leukocyte-rich cell extracts, detection by Western blot
Manually annotated by BRENDA team
bleomycin hydrolase detected by immunohistochemistry
Manually annotated by BRENDA team
of 6-week-old rats, tissue amounts of bleomycin hydrolase determined
Manually annotated by BRENDA team
hemo-lymphocytic lineage cell line, bleomycin hydrolase detection by Western blot
Manually annotated by BRENDA team
of 6-week-old rats, tissue amounts of bleomycin hydrolase determined
Manually annotated by BRENDA team
of 6-week-old rats, red pulpy region, detected by immunohistochemistry
Manually annotated by BRENDA team
of 6-week-old rats, tissue amounts of bleomycin hydrolase determined
Manually annotated by BRENDA team
6-week-old male rats, tissue amounts of bleomycin hydrolase determined
Manually annotated by BRENDA team
6-week-old female rats, tissue amounts of bleomycin hydrolase determined
Manually annotated by BRENDA team
additional information
-
no expression in Hodgkin's lymphoma cells
Manually annotated by BRENDA team