3.4.22.40: bleomycin hydrolase
This is an abbreviated version!
For detailed information about bleomycin hydrolase, go to the full flat file.
Word Map on EC 3.4.22.40
-
3.4.22.40
-
luteinizing
-
paraoxonase
-
thiolactone
-
helveticus
-
peplomycin
-
lutropins
-
corneocytes
-
homocysteinylation
-
beta-naphthylamide
-
medicine
-
hcy-thiolactone
- 3.4.22.40
-
luteinizing
- paraoxonase
- thiolactone
- helveticus
- peplomycin
-
lutropins
- corneocytes
-
homocysteinylation
- beta-naphthylamide
- medicine
-
hcy-thiolactone
Reaction
Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred =
Synonyms
aminopeptidase C, aminopeptidase H, ApsC, BANA-hydrolase, BH, BH protein, Bleomycin hydrolase, BLH, Blh1p, BLM hydrolase, Blmh, BLMH protein, BMH, citrulline aminopeptidase, Gal6p, Hcy-thiolactonase, homocysteine thiolactonase, HTLase, hydrolase H, More, PEPC, yBLH, yeast cysteine protease
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Reference on EC 3.4.22.40 - bleomycin hydrolase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mistou, M.Y.; Gripon, J.C.
Catalytic properties of the cysteine aminopeptidase PepC, a bacterial bleomycin hydrolase
Biochim. Biophys. Acta
1383
63-70
1998
Lactococcus lactis
Niemer, I.; Mueller, G.; Strobel, G.; Bandlow, W.
Bleomycin hydrolase (Blh1p), a multi-sited thiol protease in search of a distinct physiological role
Curr. Genet.
32
41-51
1997
Saccharomyces cerevisiae
Schwartz, D.R.; Homanics, G.E.; Hoyt, D.G.; Klein, D.G.; Klein, E.; Abernethy, J.; Lazo, J.S.
The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance
Proc. Natl. Acad. Sci. USA
96
4680-4685
1999
Mus musculus
Zheng, W.; Johnston, S.A.
The nucleic acid binding activity of bleomycin hydrolase is involved in bleomycin detoxification
Mol. Cell. Biol.
18
3580-3585
1998
Saccharomyces cerevisiae
Lefterov, I.M.; Koldamova, R.P.; King, J.; Lazo, J.S.
The C-terminus of human bleomycin hydrolase is required for protection against bleomycin-induced chromosomal damage
Mutat. Res.
421
1-7
1998
Homo sapiens
Sebti, S.M.; Mignano, J.E.; Jani, J.P.; Srimatkandada, S.; Lazo, J.S.
Bleomycin hydrolase: molecular cloning, sequencing, and biochemical studies reveal membership in the cysteine proteinase family
Biochemistry
28
6544-6548
1989
Gallus gallus, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Papio hamadryas, Lithobates catesbeianus, Rattus norvegicus
Sebti, S.M.; Celeon, J.C.; Lazo, J.S.
Purification, characterization, and amino acid composition of rabbit pulmonary bleomycin hydrolase
Biochemistry
26
4213-4219
1987
Oryctolagus cuniculus
Broemme, D.; Rossi, A.B.; Smeekens, S.P.; Anderson, D.C.; Payan, D.G.
Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization
Biochemistry
35
6706-6714
1996
Homo sapiens
Adachi, H.; Tsujimoto, M.; Fukasawa, M.; Sato, Y.; Arai, H.; Inoue, K.; Nishimura, T.
cDNA cloning and expression of chicken aminopeptidase H, possessing endopeptidase as well as aminopeptidase activity
Eur. J. Biochem.
245
283-288
1997
Gallus gallus
O'Farrel, P.; Gonzalez, F.; Zheng, W.; Johnston, S.A.; Joshua-Tor, L.
Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease
Structure Fold. Des.
15
619-627
1999
Homo sapiens
-
Zheng, W.; Xu, H.E.; Johnston, S.A.
The cysteine-peptidase bleomycin hydrolase is a member of the galactose regulon in yeast
J. Biol. Chem.
272
30350-30355
1997
Saccharomyces cerevisiae (Q01532), Saccharomyces cerevisiae
Zheng, W.; Johnston, S.A.; Joshua-Tor, L.
The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase
Cell
93
103-109
1998
Saccharomyces cerevisiae (Q01532)
Akiyama, S.I.; Ikezaki, K.; Kuramochi, H.; Takahashi, K.; Kuwano, M.
Bleomycin-resistant cells contain increased bleomycin-hydrolase activities
Biochem. Biophys. Res. Commun.
101
55-60
1981
Cricetulus griseus
Sebti, S.M.; DeLeon, J.C.; Ma, L.T.; Hecht, S.M.; Lazo, J.S.
Substrate specificity of bleomycin hydrolase
Biochem. Pharmacol.
38
141-147
1989
Oryctolagus cuniculus
Nishimura, C.; Tanaka, N.; Suzuki, H.; Tanaka, N.
Purification of bleomycin hydrolase with a monoclonal antibody and its characterization
Biochemistry
26
1574-1578
1987
Oryctolagus cuniculus
Lazo, J.S.; Merrill, W.W.; Pham, E.T.; Lynch, T.J.; McCallister, J.D.; Ingbar, D.H.
Bleomycin hydrolase activity in pulmonary cells
J. Pharmacol. Exp. Ther.
231
583-588
1984
Bos taurus, Oryctolagus cuniculus
Lazo, J.S.; Boland, C.J.; Schwartz, P.E.
Bleomycin hydrolase activity and cytotoxicity in human tumors
Cancer Res.
42
4026-4031
1982
Homo sapiens
Basten, D.E.J.W.; Dekker, P.J.T.; Schaap, P.J.
Aminopeptidase C of Aspergillus niger is a novel phenylalanine aminopeptidase
Appl. Environ. Microbiol.
1246-1250
69
2003
Aspergillus niger (Q8J219)
-
Lefterov, I.M.; Koldamova, R.P.; Lefterova, M.; Schwartz, D-R.; Lazo, J.S.
Cysteine 73 in bleomycin hydrolase is critical for amyloid precursor protein processing
Biochem. Biophys. Res. Commun.
283
994-999
2001
Homo sapiens
Lefterov, I.M.; Koldamova, R.P.; Lazo, J.S.
Human bleomycin hydrolase regulates the secretion of amyloid precursor protein
FASEB J.
14
1837-1847
2000
Homo sapiens
Joshua-Tor, L.; Johnston, S.A.
Bleomycin hydrolase
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press
2
1197-1201
2004
Saccharomyces cerevisiae, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus, Streptomyces verticillus
-
Zimny, J.; Sikora, M.; Guranowski, A.; Jakubowski, H.
Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase
J. Biol. Chem.
281
22485-22492
2006
Saccharomyces cerevisiae, Homo sapiens
Nuver, J.; Lutke Holzik, M.F.; van Zweeden, M.; Hoekstra, H.J.; Meijer, C.; Suurmeijer, A.J.; Groen, H.J.; Hofstra, R.M.; Sluiter, W.J.; Groen, H.; Sleijfer, D.T.; Gietema, J.A.
Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients
Pharmacogenet. Genomics
15
399-405
2005
Homo sapiens
Kajiya, A.; Kaji, H.; Isobe, T.; Takeda, A.
Processing of amyloid beta-peptides by neutral cysteine protease bleomycin hydrolase
Protein Pept. Lett.
13
119-123
2006
Rattus norvegicus
OFarrell, P.A.; Joshua-Tor, L.
Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure
Biochem. J.
401
421-428
2007
Saccharomyces cerevisiae (Q01532), Saccharomyces cerevisiae
Kamata, Y.; Itoh, Y.; Kajiya, A.; Karasawa, S.; Sakatani, C.; Takekoshi, S.; Osamura, R.Y.; Takeda, A.
Quantification of neutral cysteine protease bleomycin hydrolase and its localization in rat tissues
J. Biochem.
141
69-76
2007
Rattus norvegicus (P70645)
de Haas, E.C.; Zwart, N.; Meijer, C.; Nuver, J.; Boezen, H.M.; Suurmeijer, A.J.; Hoekstra, H.J.; van der Steege, G.; Sleijfer, D.T.; Gietema, J.A.
Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer
J. Clin. Oncol.
26
1817-1823
2008
Homo sapiens (Q13867), Homo sapiens
Towne, C.F.; York, I.A.; Watkin, L.B.; Lazo, J.S.; Rock, K.L.
Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses
J. Immunol.
178
6923-6930
2007
Mus musculus (Q8R016)
Montoya, S.E.; Thiels, E.; Card, J.P.; Lazo, J.S.
Astrogliosis and behavioral changes in mice lacking the neutral cysteine protease bleomycin hydrolase
Neuroscience
146
890-900
2007
Mus musculus (Q8R016)
Kamata, Y.; Taniguchi, A.; Yamamoto, M.; Nomura, J.; Ishihara, K.; Takahara, H.; Hibino, T.; Takeda, A.
Neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids
J. Biol. Chem.
284
12829-12836
2009
Homo sapiens, Rattus norvegicus
Borowczyk, K.; Tisonczyk, J.; Jakubowski, H.
Metabolism and neurotoxicity of homocysteine thiolactone in mice: protective role of bleomycin hydrolase
Amino Acids
43
1339-1348
2012
Mus musculus
Ratovitski, T.; Chighladze, E.; Waldron, E.; Hirschhorn, R.R.; Ross, C.A.
Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin
J. Biol. Chem.
286
12578-12589
2011
Homo sapiens
Kamata, Y.; Yamamoto, M.; Kawakami, F.; Tsuboi, R.; Takeda, A.; Ishihara, K.; Hibino, T.
Bleomycin hydrolase is regulated biphasically in a differentiation- and cytokine-dependent manner: relevance to atopic dermatitis
J. Biol. Chem.
286
8204-8212
2011
Homo sapiens
Suszynska-Zajczyk, J.; Wroblewski, J.; Utyro, O.; Luczak, M.; Marczak, L.; Jakubowski, H.
Bleomycin hydrolase and hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis
Amino Acids
46
1471-1480
2014
Mus musculus
Chen, J.; Chen, Y.; He, Q.
Action of bleomycin is affected by bleomycin hydrolase but not by caveolin-1
Int. J. Oncol.
41
2245-2252
2012
Homo sapiens
Crnovcic, I.; Gan, F.; Yang, D.; Dong, L.B.; Schultz, P.G.; Shen, B.
Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity
Bioorg. Med. Chem. Lett.
28
2670-2674
2018
Homo sapiens (Q13867), Homo sapiens
van der Linden, W.A.; Segal, E.; Child, M.A.; Byzia, A.; Drag, M.; Bogyo, M.
Design and synthesis of activity-based probes and inhibitors for bleomycin hydrolase
Chem. Biol.
22
995-1001
2015
Mus musculus (Q8R016)
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