3.4.22.40: bleomycin hydrolase

This is an abbreviated version!
For detailed information about bleomycin hydrolase, go to the full flat file.

Word Map on EC 3.4.22.40

Reaction

Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred =

Synonyms

More, PEPC, aminopeptidase C, hydrolase H, BANA-hydrolase, Blh1p, Gal6p, aminopeptidase H, Bleomycin hydrolase, BLM hydrolase, BMH, ApsC, BH, yeast cysteine protease, yBLH, homocysteine thiolactonase, Hcy-thiolactonase, HTLase, BLH, BH protein, BLMH protein, citrulline aminopeptidase, Blmh

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.40 bleomycin hydrolase

Natural Substrates Products

Natural Substrates Products on EC 3.4.22.40 - bleomycin hydrolase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
bleomycin + H2O
?
show the reaction diagram
bleomycin A2 + H2O
deamido bleomycin A2 + NH3
show the reaction diagram
the enzyme hydrolyzes bleomycins into the biologically inactive deamido bleomycins
-
-
?
bleomycin B2 + H2O
deamido bleomycin B2 + NH3
show the reaction diagram
the enzyme hydrolyzes bleomycins into the biologically inactive deamido bleomycins
-
-
?
deiminated filaggrin + H2O
?
show the reaction diagram
homocysteine-thiolactone + H2O
?
show the reaction diagram
-
-
-
-
?
huntingtin + H2O
?
show the reaction diagram
-
the enzyme is involved in a specific cleavage step at the N-terminal fragment cp-2 site of huntingtin
-
-
?
L-homocysteine-thiolactone + H2O
L-homocysteine
show the reaction diagram
-
-
-
-
?
Z-Leu-Leu-Glu-NH-4-nitroanilide + H2O
Z-Leu-Leu-Glu + 4-nitroaniline
show the reaction diagram
-
no activity in vitro due to requirement of binding to DNA-recognition sites of ztranscriptional activator Gal4p
-
-
?
additional information
?
-