3.4.22.40: bleomycin hydrolase
This is an abbreviated version!
For detailed information about bleomycin hydrolase, go to the full flat file.
Word Map on EC 3.4.22.40
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3.4.22.40
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luteinizing
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paraoxonase
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thiolactone
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helveticus
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peplomycin
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lutropins
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corneocytes
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homocysteinylation
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beta-naphthylamide
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medicine
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hcy-thiolactone
- 3.4.22.40
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luteinizing
- paraoxonase
- thiolactone
- helveticus
- peplomycin
-
lutropins
- corneocytes
-
homocysteinylation
- beta-naphthylamide
- medicine
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hcy-thiolactone
Reaction
Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred =
Synonyms
aminopeptidase C, aminopeptidase H, ApsC, BANA-hydrolase, BH, BH protein, Bleomycin hydrolase, BLH, Blh1p, BLM hydrolase, Blmh, BLMH protein, BMH, citrulline aminopeptidase, Gal6p, Hcy-thiolactonase, homocysteine thiolactonase, HTLase, hydrolase H, More, PEPC, yBLH, yeast cysteine protease
ECTree
3.4.22.40 bleomycin hydrolaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.22.40 - bleomycin hydrolase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
bleomycin A2 + H2O
deamido bleomycin A2 + NH3
the enzyme hydrolyzes bleomycins into the biologically inactive deamido bleomycins
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-
?
bleomycin B2 + H2O
deamido bleomycin B2 + NH3
the enzyme hydrolyzes bleomycins into the biologically inactive deamido bleomycins
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-
?
huntingtin + H2O
?
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the enzyme is involved in a specific cleavage step at the N-terminal fragment cp-2 site of huntingtin
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-
?
Z-Leu-Leu-Glu-NH-4-nitroanilide + H2O
Z-Leu-Leu-Glu + 4-nitroaniline
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no activity in vitro due to requirement of binding to DNA-recognition sites of ztranscriptional activator Gal4p
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-
?
bleomycin + H2O
?
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bleomycin is a cytotoxic agent inducing pneumonitis, detoxification reaction
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?
bleomycin + H2O
?
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detoxification reaction, high enzyme expression level leads to resistance against the drug
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?
deiminated filaggrin + H2O
?
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neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids
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?
deiminated filaggrin + H2O
?
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neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids
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-
?
additional information
?
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the enzyme exhibits protection against homocysteine toxicity, role and mechanisms of bleomycin hydrolase, overview
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?
additional information
?
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role in generating MHC class I-presented peptides suggested
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?
additional information
?
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bleomycin hydrolase does not hydrolyze D-Hcy-thiolactone
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?
additional information
?
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the enzyme exhibits protection against homocysteine toxicity, role and mechanisms of bleomycin hydrolase, overview
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?
additional information
?
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the enzyme expression is regulated by galactose and Gal4p,expression pattrern
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?
