3.4.22.40: bleomycin hydrolase

This is an abbreviated version!
For detailed information about bleomycin hydrolase, go to the full flat file.

Reaction

Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred =

Synonyms

aminopeptidase C, aminopeptidase H, ApsC, BANA-hydrolase, BH, BH protein, Bleomycin hydrolase, BLH, Blh1p, BLM hydrolase, Blmh, BLMH protein, BMH, citrulline aminopeptidase, Gal6p, Hcy-thiolactonase, homocysteine thiolactonase, HTLase, hydrolase H, More, PEPC, yBLH, yeast cysteine protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.40 bleomycin hydrolase

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Results	in table
4	Activating Compound
2648	AA Sequence
9	Application
1	CAS Registry Number
18	Cloned(Commentary)
3	Crystallization (Commentary)
265	Disease/ Diagnostics
3	Expression
6	General Information
1	General Stability
6	IC50 Value
57	Inhibitors
7	kcat/KM [mM/s]
52	KM Value [mM]
15	Localization
1	Metals/Ions
18	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
51	Organism
13	PDB ID
15	pH Optimum
4	pH Range
1	Posttranslational Modification
13	Protein Variants
12	Purification (Commentary)
3	Reaction
1	Reaction Type
51	Reference
56	Source Tissue
9	Specific Activity [micromol/min/mg]
130	Substrates and Products (Substrate)
13	Subunits
44	Synonyms
4	Temperature Optimum [°C]
3	Temperature Stability [°C]
7	Turnover Number [1/s]

General Information

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General Information on EC 3.4.22.40 - bleomycin hydrolase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

4 entries

metabolism

Homo sapiens

Q13867

Ubc9 plays different roles of action in antitumor agents in chemotherapy. The process requires bleomycin hydrolase and poly(ADP-ribose) polymerase-1

753931

physiological function

Mus musculus

-

bleomycin hydrolase protects against L-homocysteine-thiolactone toxicity in brain and kidney

717080

malfunction

Mus musculus

-

bleomycin hydrolase knockout mice excrete up to 10fold more L-homocysteine-thiolactone than normal animals

717080

malfunction

Homo sapiens

-

knockdown of bleomycin hydrolase reduces cp-2 cleavage, and ameliorates mutant huntingtin induced toxicity

717821

malfunction

Mus musculus

-

proteins involved in lipid homeostasis (ApoE), energy metabolism (Atp5h), oxidative stress response (Sod1), nitric oxide generation (Ddah1), and metabolic detoxification (Glo1, Sult1c1) were differentially expressed in livers of bleomycin hydrolase-null mice. Proteins involved in lipoprotein metabolism (ApoA1), antigen processing (Psme1), energy metabolism (Gamt), catechol metabolism (Comt) show differential expression in bleomycin hydrolase-deficient mice only in animals fed with a hyperhomocysteinemic diet

731117

malfunction

Homo sapiens

-

the sensitivity to bleomycin is increased in HeLa cells after knockdown of bleomycin hydrolase

731954