3.4.22.40: bleomycin hydrolase

This is an abbreviated version!
For detailed information about bleomycin hydrolase, go to the full flat file.

Word Map on EC 3.4.22.40

Reaction

Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred =

Synonyms

More, PEPC, aminopeptidase C, hydrolase H, BANA-hydrolase, Blh1p, Gal6p, aminopeptidase H, Bleomycin hydrolase, BLM hydrolase, BMH, ApsC, BH, yeast cysteine protease, yBLH, homocysteine thiolactonase, Hcy-thiolactonase, HTLase, BLH, BH protein, BLMH protein, citrulline aminopeptidase, Blmh

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.40 bleomycin hydrolase

Engineering

Engineering on EC 3.4.22.40 - bleomycin hydrolase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C73A
-
inactive mutant
truncated C-terminus
-
C-terminus is essential for protection against bleomycin induced chromatin breaks
C73S
-
ectopic expression of enzyme increases the secretion of amyloid precursor protein, increase is blocked in mutant
V443I
-
the naturally occurring polymorphism of the gene encoding the enzyme is associated to sporadic Alzheimer's disease and to the amyloid precursor protein
H369A
N392L
structural and catalytic effects of mutations shown
N392A
structural and catalytic effects of mutations summarized
N392V
structural and catalytic effects of mutations shown
H369L
structural and catalytic effects of mutations shown
Q67E
structural and catalytic effects of mutations indicated
additional information