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3.4.22.40: bleomycin hydrolase

This is an abbreviated version!
For detailed information about bleomycin hydrolase, go to the full flat file.

Word Map on EC 3.4.22.40

Reaction

Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred =

Synonyms

aminopeptidase C, aminopeptidase H, ApsC, BANA-hydrolase, BH, BH protein, Bleomycin hydrolase, BLH, Blh1p, BLM hydrolase, Blmh, BLMH protein, BMH, citrulline aminopeptidase, Gal6p, Hcy-thiolactonase, homocysteine thiolactonase, HTLase, hydrolase H, More, PEPC, yBLH, yeast cysteine protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.40 bleomycin hydrolase

Cloned

Cloned on EC 3.4.22.40 - bleomycin hydrolase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
determination of DNA sequence and genotypes in 340 different male germ cell probes
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DNA sequence determination
DNA sequence determination and analysis, chromosome localization at 19q11.2
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expressed in Escherichia coli
expressed in Escherichia coli, mutant generation described
expressed in HT-22 cells
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expression in CHO-K1 cells
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expression in COS7 cells
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expression in Escherichia coli
expression in Sf9/baculovirus cells
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expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
gene YCP1 or BLH1, DNA sequence determination
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