3.4.22.30: Caricain
This is an abbreviated version!
For detailed information about Caricain, go to the full flat file.
Word Map on EC 3.4.22.30
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3.4.22.30
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proteinases
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latex
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actinidin
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ficin
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catalytic-site
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glycyl
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papain-like
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2,2\'-dipyridyl
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active-centre
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drug development
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food industry
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nutrition
- 3.4.22.30
- proteinases
- latex
- actinidin
- ficin
-
catalytic-site
-
glycyl
-
papain-like
-
2,2\'-dipyridyl
-
active-centre
- drug development
- food industry
- nutrition
Reaction
hydrolysis of proteins with broad specificity for peptide bonds, similar to those of papain and chymopapain =
Synonyms
caricain, Chymopapain S, More, Papaya peptidase A, Papaya peptidase II, Papaya proteinase 3, Papaya proteinase A, Papaya proteinase III, Papaya proteinase OMEGA, PPIII, PpOmega, procaricain, Proteinase omega, Proteinase, papaya A, Proteinase, papaya, III
ECTree
3.4.22.30 CaricainAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.4.22.30 - Caricain
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alpha-N-benzoyl-L-arginine 4-nitroanilide + H2O
alpha-N-benzoyl-L-arginine + 4-nitroaniline
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?
N-acetyl-Phe-Gly methylthionoester + H2O
?
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synthetic chromogenic substrate, reaction mechanism, computer modeling of intermediate formation
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?
N-benzoyl-L-arginine ethyl ester + H2O
N-benzoyl-L-arginine + ethanol
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isoform caricain II, low activity
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?
N-tosyl-L-Arg methyl ester + H2O
N-tosyl-L-Arg + methanol
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less active than papain
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?
Nalpha-benzoyl-L-Arg-4-nitroanilide + H2O
Nalpha-benzoyl-L-Arg + 4-nitroaniline
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?
pyr-Glu-Phe-Leu-4-nitroanilide + H2O
pyr-Glu-Phe-Leu + 4-nitroaniline
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?
casein + H2O
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isoform caricain II, twofold activity on casein compared to caricain
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?
Gliadin + H2O
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a rat liver lysosome assay is used to monitor the extent of detoxification of a gliadin digest by caricain. Pre-incubating the gliadin digest for different durations with caricain allows the kinetics of the detoxification process to be studied. A significant degree of protection (80%) of the lysosomes is achieved with 1.7% w/w of caricain on substrate after incubation for 2 h at 37 °C. The detoxification follows first-order kinetics with a rate constant of 0.00017/sec
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?
