3.4.22.14: actinidain
This is an abbreviated version!
For detailed information about actinidain, go to the full flat file.
Word Map on EC 3.4.22.14
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3.4.22.14
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papain
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kiwifruit
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proteinases
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allergen
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kiwi
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deliciosa
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catalytic-site
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hayward
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ficin
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bromelain
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thaumatin-like
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chymopapains
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hort16a
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brocklehurst
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cysteine-proteinase
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kiwellin
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medicine
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two-protonic-state
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active-centre
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synthesis
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food industry
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nutrition
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molecular biology
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biotechnology
- 3.4.22.14
- papain
- kiwifruit
- proteinases
- allergen
-
kiwi
- deliciosa
-
catalytic-site
- hayward
- ficin
- bromelain
-
thaumatin-like
- chymopapains
-
hort16a
-
brocklehurst
-
cysteine-proteinase
- kiwellin
- medicine
-
two-protonic-state
-
active-centre
- synthesis
- food industry
- nutrition
- molecular biology
- biotechnology
Reaction
Similar to that of papain =
Synonyms
Act d 1, ACT1A-1, ACT1A-2, Actd1, actinidain, actinidia anionic protease, actinidin, mercaptoproteinase A2, proteinase A2 of Actinidia chinensis
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3.4.22.14 actinidainAdvanced search results
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General Information on EC 3.4.22.14 - actinidain
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
metabolism
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active actinidin retains its primary structure and proteolytic activity after 2 h of simulated gastric digestion, followed by 2 h of intestinal digestion
physiological function
additional information
physiological function
actinidin is important in monoallergy to kiwifruit
physiological function
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actinidin disrupts the epithelial barrier function of human intestinal T84 cells by degrading the tight junction protein occludin. Exposure of T84 cells to biologically active actinidin significantly decreases the transepithelial resistance across the intestinal epithelial monolayers
physiological function
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actinidin is both immunogenic and allergenic at relatively low doses. Vigorous IgG and IgG1 antibody and high titre IgE antibody responses are recorded in response to actinidin
additional information
the enzyme increases intestinal permeability in both in vivo (mice) and in vitro (Caco-2 cell culture) models. The food allergen with intrinsic proteolytic activity can compromise the gut epithelial barrier, contributing to the sensitization process in food allergy pathogenesis
additional information
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the enzyme increases intestinal permeability in both in vivo (mice) and in vitro (Caco-2 cell culture) models. The food allergen with intrinsic proteolytic activity can compromise the gut epithelial barrier, contributing to the sensitization process in food allergy pathogenesis
